{"id":16630,"date":"2022-09-08T18:14:00","date_gmt":"2022-09-08T21:14:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice-copy\/"},"modified":"2023-03-17T14:47:54","modified_gmt":"2023-03-17T17:47:54","slug":"success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/es\/caso-de-exito-microtomografia-de-rayos-x-de-alta-resolucion-basada-en-el-sincrotron-como-herramienta-para-desvelar-la-arquitectura-neuronal-tridimensional-del-cerebro\/","title":{"rendered":"Microtomograf\u00eda de rayos X de alta resoluci\u00f3n basada en el sincrotr\u00f3n como herramienta para desvelar la arquitectura neuronal tridimensional del cerebro Paper Review"},"content":{"rendered":"

La microtomograf\u00eda de rayos X ha surgido como un nuevo m\u00e9todo para descifrar la citoarquitectura y la conectividad del cerebro, y aqu\u00ed presentamos un m\u00e9todo para obtener im\u00e1genes de neuronas enteras.<\/p>\n\n\n\n

La microtomograf\u00eda de rayos X de alta resoluci\u00f3n basada en el sincrotr\u00f3n como herramienta para desvelar la arquitectura neuronal tridimensional del cerebro<\/strong><\/h2>\n\n\n\n

En 'High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain', Matheus de Castro Fonseca et al. (2018) se\u00f1alaron que el estudio de las neuronas como unidades individualizadas tiene su inicio en el siglo XIX con la creaci\u00f3n de la Doctrina de la Neurona. <\/p>\n\n\n\n

En los \u00faltimos a\u00f1os se han realizado grandes esfuerzos para comprender la organizaci\u00f3n y la conectividad neuronal en muestras cerebrales intactas. La t\u00e9cnica de etiquetado de Golgi-Cox ofrece un contraste adecuado para el etiquetado espec\u00edfico de las neuronas para la microtomograf\u00eda de rayos X. <\/p>\n\n\n\n

Las neuronas tienen una morfolog\u00eda distinta y patrones espec\u00edficos de conectividad, que son esenciales para su correcto funcionamiento. Los investigadores presentan un m\u00e9todo de obtenci\u00f3n de im\u00e1genes que combina la microtomograf\u00eda de rayos X basada en el sincrotr\u00f3n con el protocolo de impregnaci\u00f3n de Golgi-Cox. <\/p>\n\n\n\n

El m\u00e9todo ofrece un contraste mayor y m\u00e1s homog\u00e9neo de las neuronas enteras distribuidas de forma relativamente dispersa en el tejido.<\/p>\n\n\n\n

Los cerebros se incubaron en la soluci\u00f3n de tinci\u00f3n de Golgi-Cox durante 14 d\u00edas, protegidos de la luz. Tras el periodo de incubaci\u00f3n, los cerebros se seccionaron en serie utilizando un vibratomo.<\/strong><\/p>\n\n\n\n

Compruebe el art\u00edculo original aqu\u00ed<\/a>.<\/p>\n\n\n\n

Resumen gr\u00e1fico con tecnolog\u00eda Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
\n
\"\"<\/a>
Hecho con Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

El autor utiliz\u00f3 Mind the Graph<\/a> para crear una ilustraci\u00f3n esquem\u00e1tica que represente a un rat\u00f3n adulto al que se le inyecta i.p. una soluci\u00f3n salina o pilocarpina (280 mg\/kg). Representar procesos complejos con infograf\u00edas es una buena manera de hacerlos f\u00e1cilmente comprensibles, sin dejar de lado los detalles y la informaci\u00f3n crucial.<\/p>\n\n\n\n

Algunos de los resultados de los investigadores parecen consolidar lo que se sab\u00eda anteriormente sobre esta \u00e1rea: \"La impregnaci\u00f3n neuronal a base de mercurio mostrada aqu\u00ed, nos permiti\u00f3 definir claramente neuronas enteras principalmente por una impregnaci\u00f3n m\u00e1s continua y homog\u00e9nea de las c\u00e9lulas y una densidad mucho menor de artefactos\", sugiri\u00f3 de Castro Fonseca.<\/p>\n\n\n\n

Papeles Impacto y rendimiento<\/strong><\/h2>\n\n\n\n

Podemos analizar con Altmetric<\/a> datos que la puntuaci\u00f3n de la atenci\u00f3n en l\u00ednea de este documento es mayor que 64%<\/strong><\/strong> de todos los dem\u00e1s art\u00edculos de edad similar en Scientific Reports.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/a>
Fuente Altmetrics<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Mejore la accesibilidad de su art\u00edculo tambi\u00e9n con el poder de la infograf\u00eda.<\/p>\n\n\n\n

\n
Prueba Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Vea el nuevo m\u00e9todo para descifrar la citoarquitectura y la conectividad del cerebro representado con las ilustraciones de Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nHigh-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/es\/caso-de-exito-microtomografia-de-rayos-x-de-alta-resolucion-basada-en-el-sincrotron-como-herramienta-para-desvelar-la-arquitectura-neuronal-tridimensional-del-cerebro\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - 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