{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/es\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","title":{"rendered":"El virus del Zika se replica en el tejido cerebral humano adulto y deteriora las sinapsis y la memoria en ratones Paper Review"},"content":{"rendered":"

El ZIKV es un peligroso virus que hace estragos en el mundo. Por eso, en este caso, el autor estudia su replicaci\u00f3n en el cerebro humano adulto.<\/p>\n\n\n\n

El virus del Zika (ZIKV) infecta el tejido cerebral de los adultos y provoca trastornos de la memoria en los ratones<\/strong><\/h2>\n\n\n\n

Un grupo de la Facultad de Farmacia dirigido por Claudia Figueiredo (2019) estudi\u00f3 c\u00f3mo el virus del zika se replica en el tejido cerebral humano adulto y deteriora las sinapsis y la memoria en ratones. El virus del Zika es un arbovirus perteneciente a la familia Flaviviridae responsable de un importante brote reciente en Am\u00e9rica Latina. <\/p>\n\n\n\n

El ZIKV se ha encontrado en el cerebro y el LCR de pacientes adultos. La inmunorreactividad de NS2B se colocaliz\u00f3 con c\u00e9lulas inmunorreactivas a NeuN, pero no con GFAP o F4\/80, lo que indica que las neuronas son el objetivo del ZikV en el tejido humano maduro. En ratones adultos inmunocompetentes infectados por infusi\u00f3n intracerebroventricular del ZIKV, se detectan altos niveles de ARN del ZikV en la corteza frontal y el hipocampo, y las neuronas maduras son el principal tipo celular infectado. <\/p>\n\n\n\n

Se verifican los niveles cerebrales elevados de TNF-\u03b1, la microgliosis intensa, la expresi\u00f3n regulada de las prote\u00ednas del sistema del complemento (C1q y C3) y el da\u00f1o de la sinapsis del hipocampo.<\/p>\n\n\n\n

El estudio inclu\u00eda 9 cuadrantes iguales.<\/strong><\/p>\n\n\n\n

Compruebe el art\u00edculo original aqu\u00ed<\/a>.<\/p>\n\n\n\n

Res\u00famenes gr\u00e1ficos con tecnolog\u00eda Mind the Graph<\/strong><\/h2>\n\n\n\n
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Hecho con Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

La primera figura representa el caso en el que los fragmentos de tejido cortical del l\u00f3bulo temporal humano se seccionaron en rodajas de 400 \u00b5m y se mantuvieron en cultivo durante 4 d\u00edas antes de la incubaci\u00f3n con el ZIKV (107 PFU) o con un medio de imitaci\u00f3n durante 1 h, seguido de un lavado. <\/p>\n\n\n\n

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Hecho con Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

La segunda muestra que los ratones adultos recibieron una infusi\u00f3n de 105 PFU de ZIKV, de ZIKV inactivado por la radiaci\u00f3n ultravioleta o de un medio de burla en el ventr\u00edculo lateral cerebral.<\/p>\n\n\n\n

Las conclusiones parecen respaldar lo que se sab\u00eda anteriormente sobre este tema: \"El ZIKV se dirige a regiones cerebrales relacionadas con la memoria, independientemente de que la v\u00eda de infecci\u00f3n sea central o perif\u00e9rica. El virus se ha detectado en el LCR de pacientes adultos con complicaciones neurol\u00f3gicas\", afirm\u00f3 Figueiredo.<\/p>\n\n\n\n

Proponen que se justifiquen futuros estudios destinados a examinar el impacto neurodegenerativo a largo plazo de la infecci\u00f3n por el ZIKV. La identificaci\u00f3n de formas de prevenir las anomal\u00edas de se\u00f1alizaci\u00f3n que conducen a la disfunci\u00f3n cerebral podr\u00eda allanar el camino a las estrategias de intervenci\u00f3n para retrasar o prevenir el desarrollo de afecciones neurol\u00f3gicas importantes.<\/p>\n\n\n\n

Papeles Impacto y rendimiento<\/strong><\/h2>\n\n\n\n

Podemos analizar con Altmetric<\/a> datos que la puntuaci\u00f3n de la atenci\u00f3n en l\u00ednea de este documento es mayor que 95%<\/strong><\/strong> de todos los dem\u00e1s art\u00edculos de edad similar en la Naturaleza<\/strong> Revistas.<\/strong><\/p>\n\n\n\n

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Fuente Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\u00a1Utiliza el poder de la infograf\u00eda para impulsar tu art\u00edculo tambi\u00e9n! Inicie una creaci\u00f3n en Mind the Graph.<\/p>\n\n\n\n

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Prueba Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

El estudio trata sobre el ZIKV en el cerebro humano adulto, un peligroso virus que hace estragos en el mundo. El proceso utiliza ilustraciones Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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