{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/de\/autophagie-gewinnt-nobelpreis-medizin\/","title":{"rendered":"Autophagie erh\u00e4lt Nobelpreis f\u00fcr Medizin"},"content":{"rendered":"<p>Der Autophagieprozess ist an mehreren Krankheiten wie Krebs und neurologischen Erkrankungen beteiligt. Er funktioniert als k\u00f6rpereigenes Recyclingprogramm. Eine gest\u00f6rte Autophagie wird jedoch mit der Parkinson-Krankheit, Diabetes, Krebs und anderen altersbedingten Erkrankungen in Verbindung gebracht.<\/p>\n<p>Nach dieser kleinen Einf\u00fchrung in die Bedeutung des Autophagie-Prozesses ist es keine \u00dcberraschung, dass neue Entdeckungen auf diesem Gebiet zu einem Nobelpreis f\u00fchren k\u00f6nnten. Tats\u00e4chlich erhielt die Forscherin Yoshino Ohsumi am vergangenen Montag den <a href=\"https:\/\/www.nobelprize.org\/nobel_prizes\/medicine\/laureates\/2016\/press.html\">Nobelpreis f\u00fcr Medizin<\/a> f\u00fcr die Identifizierung der ersten wesentlichen Gene f\u00fcr die Autophagie.<\/p>\n<blockquote><p>\"Ich f\u00fchle mich nicht wohl dabei, mit vielen Leuten zu konkurrieren, und finde es stattdessen angenehmer, etwas zu tun, was sonst niemand tut. In gewisser Weise ist es das, worum es in der Wissenschaft geht, und die Freude, etwas zu finden, inspiriert mich.\" <a href=\"https:\/\/www.theguardian.com\/science\/2016\/oct\/03\/yoshinori-ohsumi-wins-nobel-prize-in-medicine\">Yoshino Ohsumi <\/a><\/p><\/blockquote>\n<h3>Wie hat Ohsumi es geschafft?<\/h3>\n<p>In seinem Labor hatte Ohsumi Hefest\u00e4mme entwickelt, die w\u00e4hrend des Hungerns Autophagosomen anh\u00e4uften. Zu dieser Anh\u00e4ufung konnte es nur kommen, wenn wesentliche Gene f\u00fcr die Autophagie inaktiv waren. So begann Ohsumi, die Zellen durch verschiedene Genmutationen zu manipulieren, und es gelang ihm, die Autophagie auszul\u00f6sen.<\/p>\n<p><a href=\"https:\/\/blog.mindthegraph.com\/want-get-published\/\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-6301\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2016\/10\/infographic671351.png\" alt=\"Autophagie erh\u00e4lt Nobelpreis f\u00fcr Medizin\" width=\"776\" height=\"582\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/10\/infographic671351.png 2400w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/10\/infographic671351-300x225.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/10\/infographic671351-768x576.png 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/10\/infographic671351-1024x768.png 1024w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><\/a><\/p>\n<h3>Autophagie gibt es schon lange<\/h3>\n<p>Obwohl die Autophagie bereits seit 50 Jahren bekannt ist, wurde die Bedeutung dieses Prozesses erst in den 1990er Jahren durch die Studien von Ohsumi erkannt.<br \/>\nF\u00fcr seine Arbeit hat Ohsumi bereits einige Fans gewonnen:<\/p>\n<p style=\"text-align: left;\"><a href=\"http:\/\/www.cimr.cam.ac.uk\/research\/principal-investigators\/principal-investigators-q-z\/rubinsztein\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-6303\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2016\/10\/rubinzstein.jpg\" alt=\"Autophagie erh\u00e4lt Nobelpreis f\u00fcr Medizin\" width=\"233\" height=\"233\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/10\/rubinzstein.jpg 1000w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/10\/rubinzstein-150x150.jpg 150w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/10\/rubinzstein-300x300.jpg 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/10\/rubinzstein-768x768.jpg 768w\" sizes=\"(max-width: 233px) 100vw, 233px\" \/><\/a><\/p>\n<blockquote>\n<p style=\"text-align: left;\">\"Ich bin sehr gl\u00fccklich, dass er den diesj\u00e4hrigen Nobelpreis erhalten hat, er hat ihn sehr verdient. Sein Labor arbeitet haupts\u00e4chlich in Hefe. Sie haben die ersten Screens durchgef\u00fchrt, die die Entdeckung von Schl\u00fcsselgenen erm\u00f6glichten, die an der Autophagie beteiligt sind. So viele andere Labors haben seine Entdeckungen direkt oder indirekt genutzt, um zu sehen, warum dies bei Krankheiten wichtig ist.<\/p>\n<p style=\"text-align: left;\"><a href=\"http:\/\/www.cimr.cam.ac.uk\/research\/principal-investigators\/principal-investigators-q-z\/rubinsztein\">David Rubinsztein<\/a> - Stellvertretender Direktor des Cambridge Institute for Medical Research<\/p>\n<\/blockquote>\n<p><a href=\"http:\/\/www.neuroscience.cam.ac.uk\/directory\/profile.php?gm522\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-6302\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2016\/10\/alzheimer-enemy-giovanna-mallucci1.jpg\" alt=\"Autophagie erh\u00e4lt Nobelpreis f\u00fcr Medizin\" width=\"205\" height=\"264\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/10\/alzheimer-enemy-giovanna-mallucci1.jpg 620w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/10\/alzheimer-enemy-giovanna-mallucci1-233x300.jpg 233w\" sizes=\"(max-width: 205px) 100vw, 205px\" \/><\/a><\/p>\n<blockquote>\n<p style=\"text-align: left;\">\"Ich denke, es ist sehr wichtig, dass dieser Bereich der Wissenschaft anerkannt wird. Das wichtige Prinzip hier ist die Suche nach gemeinsamen Mechanismen bei Krankheiten. Es er\u00f6ffnet Wege zur Behandlung dieser St\u00f6rungen, die sich von den herk\u00f6mmlichen krankheitsspezifischen Ans\u00e4tzen unterscheiden.<\/p>\n<p style=\"text-align: left;\"><a href=\"http:\/\/www.neuroscience.cam.ac.uk\/directory\/profile.php?gm522\">Giovanna Mallucci<\/a> - Professor f\u00fcr klinische Neurowissenschaften an der Universit\u00e4t von Cambridge<\/p>\n<\/blockquote>\n<p style=\"text-align: left;\"><a href=\"https:\/\/blog.mindthegraph.com\/want-get-published\/\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-5831\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2016\/06\/untitled-creation63724.png\" alt=\"Autophagie erh\u00e4lt Nobelpreis f\u00fcr Medizin\" width=\"340\" height=\"136\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/06\/untitled-creation63724.png 1500w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/06\/untitled-creation63724-300x120.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/06\/untitled-creation63724-1024x410.png 1024w\" sizes=\"(max-width: 340px) 100vw, 340px\" \/><\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Der Autophagieprozess ist an mehreren Krankheiten wie Krebs und neurologischen Erkrankungen beteiligt. Er funktioniert als k\u00f6rpereigenes Recyclingprogramm. Eine gest\u00f6rte Autophagie wird jedoch mit der Parkinson-Krankheit, Diabetes, Krebs und anderen altersbedingten Erkrankungen in Verbindung gebracht. Nach dieser kleinen Einf\u00fchrung in die Bedeutung des Autophagie-Prozesses ist es keine \u00dcberraschung, dass neue Entdeckungen [...]<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Autophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"&quot;I find it more enjoyable doing something nobody else is doing. In a way, that\u2019s what science is all about&quot; Yoshino Ohsumi about his research on autophagy.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/de\/autophagie-gewinnt-nobelpreis-medizin\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Autophagy wins Nobel Prize in medicine - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"&quot;I find it more enjoyable doing something nobody else is doing. 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