{"id":16630,"date":"2022-09-08T18:14:00","date_gmt":"2022-09-08T21:14:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice-copy\/"},"modified":"2023-03-17T14:47:54","modified_gmt":"2023-03-17T17:47:54","slug":"success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/de\/erfolgsfall-hochauflosende-synchrotron-basierte-rontgen-mikrotomographie-als-werkzeug-zur-entdeckung-der-dreidimensionalen-neuronalen-architektur-des-hirns\/","title":{"rendered":"Hochaufl\u00f6sende Synchrotron-R\u00f6ntgenmikrotomographie als Werkzeug zur Enth\u00fcllung der dreidimensionalen neuronalen Architektur des Gehirns Paper Review"},"content":{"rendered":"

Die R\u00f6ntgenmikrotomographie hat sich als neue Methode zur Entschl\u00fcsselung der Zytoarchitektur und Konnektivit\u00e4t des Gehirns etabliert, und wir stellen hier eine Methode zur Abbildung ganzer Neuronen vor.<\/p>\n\n\n\n

Hochaufl\u00f6sende Synchrotron-R\u00f6ntgenmikrotomographie als Werkzeug zur Enth\u00fcllung der dreidimensionalen neuronalen Architektur des Gehirns<\/strong><\/h2>\n\n\n\n

In \"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain\" (Hochaufl\u00f6sende Synchrotron-R\u00f6ntgenmikrotomografie als Werkzeug zur Enth\u00fcllung der dreidimensionalen neuronalen Architektur des Gehirns) stellen Matheus de Castro Fonseca et al. (2018) fest, dass die Untersuchung von Neuronen als individualisierte Einheiten ihren Anfang im 19. Jahrhundert mit der Schaffung der Neuronen-Doktrin nahm. <\/p>\n\n\n\n

In den letzten Jahren wurden gro\u00dfe Anstrengungen unternommen, um die neuronale Organisation und Konnektivit\u00e4t in intakten Gehirnproben zu verstehen. Die Golgi-Cox-Markierungstechnik bietet einen geeigneten Kontrast f\u00fcr die spezifische Markierung von Neuronen f\u00fcr die R\u00f6ntgenmikrotomografie. <\/p>\n\n\n\n

Neuronen haben eine ausgepr\u00e4gte Morphologie und spezifische Vernetzungsmuster, die f\u00fcr ihr reibungsloses Funktionieren unerl\u00e4sslich sind. Die Forscher stellen eine Bildgebungsmethode vor, die Synchrotron-R\u00f6ntgenmikrotomografie mit dem Golgi-Cox-Impr\u00e4gnierungsprotokoll kombiniert. <\/p>\n\n\n\n

Die Methode bietet einen h\u00f6heren und homogeneren Kontrast von relativ sp\u00e4rlich verteilten ganzen Neuronen innerhalb des Gewebes.<\/p>\n\n\n\n

Die Gehirne wurden 14 Tage lang vor Licht gesch\u00fctzt in Golgi-Cox-F\u00e4rbel\u00f6sung inkubiert. Nach der Inkubationszeit wurden die Gehirne mit einem Vibratom seriell geschnitten.<\/strong><\/p>\n\n\n\n

Pr\u00fcfen Sie die Originalartikel hier<\/a>.<\/p>\n\n\n\n

Grafische Zusammenfassung powered by Mind the Graph<\/strong><\/h2>\n\n\n\n
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Hergestellt mit Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Der Autor verwendet Mind the Graph<\/a> eine schematische Illustration zu erstellen, die eine erwachsene Maus darstellt, der i.p. Kochsalzl\u00f6sung oder Pilocarpinl\u00f6sung (280 mg\/kg) injiziert wird. Die Darstellung komplexer Vorg\u00e4nge mit Hilfe von Infografiken ist eine gute M\u00f6glichkeit, sie leicht verst\u00e4ndlich zu machen, ohne dabei die Details und wichtigen Informationen au\u00dfer Acht zu lassen.<\/p>\n\n\n\n

Einige der Ergebnisse der Forscher scheinen zu konsolidieren, was zuvor \u00fcber diesen Bereich bekannt war: \"Die hier gezeigte Impr\u00e4gnierung von Neuronen auf Quecksilberbasis erm\u00f6glichte es uns, ganze Neuronen klar zu definieren, vor allem aufgrund einer kontinuierlichen und homogenen Impr\u00e4gnierung der Zellen und einer wesentlich geringeren Dichte von Artefakten\", so de Castro Fonseca.<\/p>\n\n\n\n

Papiere Wirkung und Leistung<\/strong><\/h2>\n\n\n\n

Wir k\u00f6nnen analysieren mit Altmetric<\/a> Daten, dass der Online-Aufmerksamkeitswert dieser Zeitung h\u00f6her ist als 64%<\/strong><\/strong> aller anderen Artikel eines \u00e4hnlichen Alters in Scientific Reports.<\/strong><\/p>\n\n\n\n

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Quelle Altmetrik<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Verbessern Sie die Zug\u00e4nglichkeit Ihres Artikels auch mit der Kraft von Infografiken.<\/p>\n\n\n\n

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Versuchen Sie Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Schauen Sie sich die neue Methode zur Entschl\u00fcsselung der Zytoarchitektur und Konnektivit\u00e4t des Gehirns an, die mit den Illustrationen von Mind the Graph dargestellt wird.<\/p>","protected":false},"author":29,"featured_media":20013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nHigh-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/de\/erfolgsfall-hochauflosende-synchrotron-basierte-rontgen-mikrotomographie-als-werkzeug-zur-entdeckung-der-dreidimensionalen-neuronalen-architektur-des-hirns\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - 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