{"id":9012,"date":"2019-06-03T11:07:17","date_gmt":"2019-06-03T14:07:17","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=9012"},"modified":"2022-10-18T08:23:58","modified_gmt":"2022-10-18T11:23:58","slug":"award-zika-virus-infection","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/da\/pris-zika-virus-infektion\/","title":{"rendered":"Zika-virus: Det prisbel\u00f8nnede studie, der kaster nyt lys over de langsigtede konsekvenser"},"content":{"rendered":"

Det er altid fantastisk at vise vores brugeres videnskabelige arbejde. S\u00e5 i dag vil jeg pr\u00e6sentere dig for den brasilianske forsker Isis de Souza og hendes arbejde med zikavirus. Isis og hendes kolleger unders\u00f8ger virkningen af zikavirusinfektion hos mus tidligt i livet. Hun bruger ogs\u00e5 Mind the Graph, og vinderpr\u00e6sentationen har visuelle ressourcer fra Mind the Graph. Vi kunne ikke v\u00e6re mere stolte.<\/p>\n

Hvad er zikavirus?<\/strong><\/h3>\n

Zika-virus tilh\u00f8rer familien Flaviviridae. Denne gruppe omfatter flere sygdomsfremkaldende virus. Den mest kendte er gul feber-virus, som er familiens typevirus og ogs\u00e5 \u00e5rsagen til familienavnet, da ordet flavus betyder \"gul\" p\u00e5 latin. Derudover er andre flavivirus West Nile-virus, dengue-virus og fl\u00e5tb\u00e5ren encephalitisvirus.<\/p>\n

Flaviviridae-familien har f\u00e6lles st\u00f8rrelse (40-65 nm) og virushylstre, der d\u00e6kker deres beskyttende ikosaedriske nukleokapsid. Det genetiske materiale er ogs\u00e5 RNA, og de kan ses i elektronmikroskopet.<\/p>\n

Infografikken nedenfor viser den grundl\u00e6ggende struktur af zikavirus:<\/p>\n

\"preview_90481\"<\/a><\/p>\n

 Zika spredes prim\u00e6rt af den kvindelige Stegomya aegypti<\/em> myg, som suger blod for at l\u00e6gge \u00e6g. Myggen er mest aktiv i dagtimerne.<\/p>\n

Vinderpapiret<\/strong><\/h2>\n

For nylig har mange forskere unders\u00f8gt de neurologiske lidelser, der er relateret til den medf\u00f8dte eksponering for zikavirus (ZIKV).<\/p>\n

Desuden er medf\u00f8dt mikrocefali en af de mest markante effekter, der er rapporteret hos ZIKV-inficerede nyf\u00f8dte. Derfor er forskningsindsatsen fokuseret p\u00e5 at forst\u00e5 mekanismerne bag ZIKV-induceret medf\u00f8dt mikrocefali.<\/p>\n

Men kun 1 til 13% af de eksponerede fostre viser fysiske misdannelser ved f\u00f8dslen. Derudover er der mangel p\u00e5 information om de langsigtede konsekvenser af en perinatal infektion.<\/p>\n

S\u00e5 Isis de Souza og hendes kolleger brugte mus til at studere de adf\u00e6rdsm\u00e6ssige og neuropatologiske forhold og kort- og langsigtede konsekvenser og offentligg\u00f8r resultaterne i en artikel med titlen Akutte og kroniske neurologiske konsekvenser af infektion med zikavirus tidligt i livet hos mus.<\/strong><\/p>\n

Hos mennesker er der mange kliniske tilstande forbundet med eksponering for zikavirus, som viser sig m\u00e5neder eller \u00e5r efter f\u00f8dslen. S\u00e5 selv om b\u00f8rnene ikke f\u00f8des med mikrocefali, kan de have motoriske forstyrrelser, kortikal dysplasi relateret til anfald og andre neurologiske lidelser.<\/p>\n

If\u00f8lge forfatterne har de \"Vi inficerede nyf\u00f8dte vildtype-mus systemisk med ZIKV og udf\u00f8rte en langsigtet opf\u00f8lgning af de adf\u00e6rdsm\u00e6ssige, neuropatologiske og molekyl\u00e6re konsekvenser af infektionen. Vi rapporterer om kort- og langsigtede komplikationer efter ZIKV-infektion i mus og viser, at tidlig neutralisering af tumornekrosefaktor-\u03b1 (TNF-\u03b1) delvist forhindrer disse skadelige virkninger. Vores resultater afsl\u00f8rer behovet for s\u00e6rlig opm\u00e6rksomhed p\u00e5 en potentiel byrde af neuropatologiske komplikationer hos b\u00f8rn og unge efter medf\u00f8dt eksponering for ZIKV og antyder, at tidlig h\u00e6mning af neuroinflammation kan v\u00e6re en potentiel behandling for at forhindre langsigtede neurologiske f\u00f8lger hos ZIKV-inficerede sp\u00e6db\u00f8rn.\"<\/em><\/p>\n

 Prisen uddeles af GE Healthcare Life Sciences<\/strong><\/h2>\n

\"Pr\u00eamio Jovem Talento em Ci\u00eancias da Vida\" eller Young Talent Award in Life Sciences uddeles af Brazilian Society of Biochemistry and Molecular Biology og GE Healthcare Life Sciences. En videnskabelig komit\u00e9 valgte fem kandidater til at pr\u00e6sentere deres arbejde p\u00e5 den \u00e5rlige kongres, en begivenhed, der forbinder professorer og studerende fra hele Latinamerika.<\/p>\n

Komit\u00e9en valgte Isis de Oliveira, og hun pr\u00e6senterede sin unders\u00f8gelse af konsekvenserne af eksponering for zikavirus.<\/p>\n

\"videnskabelig
Isis de Oliveira pr\u00e6senterer sine resultater<\/figcaption><\/figure>\n

Hun skrev et indl\u00e6g, hvor hun takkede sit universitet og det stipendium, der gjorde det muligt for hende at studere. Desuden udtrykte hun h\u00e5b om, at den fremtidige generation ville f\u00e5 mulighed for at forf\u00f8lge en videnskabelig karriere, som hun selv havde gjort.<\/p>\n

S\u00e5 vi vil gerne lyk\u00f8nske Isis med hendes fantastiske arbejde! Jeg h\u00e5ber, hun inspirerer flere mennesker til at blive forskere med sit arbejde.<\/p>\n

Og hvis du vil g\u00f8re dine data mere visuelle for at kommunikere bedre inden for videnskab, kan du pr\u00f8ve Mind the Graph:<\/p>\n

\"Husk<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Det er altid fantastisk at vise vores brugeres videnskabelige arbejde. S\u00e5 i dag vil jeg pr\u00e6sentere dig for den brasilianske forsker Isis de Souza og hendes arbejde med zikavirus. Isis og hendes kolleger unders\u00f8ger virkningen af zikavirusinfektion hos mus tidligt i livet. Hun er ogs\u00e5 en mind the graph-bruger, og vinderpr\u00e6sentationen har [...]<\/p>","protected":false},"author":11,"featured_media":9080,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[40],"tags":[299,282,554,71,775,293,316,315],"yoast_head":"\nZika virus: the award-winning study that sheds light on the future<\/title>\n<meta name=\"description\" content=\"Microcephaly is a known effect related to congenital exposure to zika virus. 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