{"id":8064,"date":"2018-08-23T15:56:09","date_gmt":"2018-08-23T18:56:09","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8064"},"modified":"2022-10-18T08:30:53","modified_gmt":"2022-10-18T11:30:53","slug":"alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/da\/alzheimers-sygdom\/","title":{"rendered":"Alzheimers sygdom: En videnskabelig infografik"},"content":{"rendered":"

Det er altid en fest, n\u00e5r vi ser vores brugeres fantastiske arbejde.\u00a0Jeg har allerede skrevet<\/a> om forskningen af Dr. Alessandra Martini, Dr.\u00a0Stefania Forner<\/a>\u00a0og deres kolleger. De er postdoktorale forskere ved University of California og har \u00f8je for grafbrugerne. For et par m\u00e5neder siden viste jeg Infografikken<\/a>\u00a0Dr. Stefania Forner st\u00e5r bag oversigtsartiklen Trends in Neurosciences med titlen Synaptic impairment in Alzheimer's Disease: En dysreguleret symfoni.<\/p>\n

I dag vil jeg tale om deres nye oversigtsartikel med titlen Fra fortid til fremtid: Hvad dyremodeller har l\u00e6rt os om Alzheimers sygdom.<\/a><\/p>\n

Alzheimers sygdom (AD) er en neurodegenerativ lidelse, der for\u00e5rsager kognitive mangler og hukommelsestab. Det er vigtigt at forst\u00e5 sygdomsmekanismen for at forbedre patienternes livskvalitet og finde en effektiv behandling. P\u00e5 trods af en enorm indsats inden for den akademiske verden og medicinalindustrien er der i dag ingen effektive behandlinger til r\u00e5dighed. Alzheimers er den sjette hyppigste d\u00f8ds\u00e5rsag i USA og rammer 35 millioner mennesker over hele verden.<\/p>\n

Infografik om Alzheimers sygdom<\/h2>\n

 <\/p>\n

St\u00f8rstedelen af AD-patienterne er \u00e6ldre mennesker, som ofte lider af en r\u00e6kke komorbiditeter. Diabetes, osteoporose, nyresygdom, fedme, forh\u00f8jet blodtryk og hypercholes-terolemi\/dyslipid\u00e6mi, slagtilf\u00e6lde og kramper er de vigtigste komorbiditeter, der p\u00e5virker udbruddet og udviklingen af Alzheimers, og som g\u00f8r sygdommens patogenese endnu mere kompliceret.<\/p>\n

\"infografik
Infografik, der viser komorbiditet ved Alzheimers sygdom (AD). Fra fortid til fremtid: Hvad dyremodeller har l\u00e6rt os om Alzheimers sygdom<\/figcaption><\/figure>\n

 <\/p>\n

\n

P\u00e5 trods af en intensiv forskningsindsats i de seneste \u00e5rtier kender man stadig ikke mekanismerne bag \u00e6tiologien bag sporadisk AD (sAD), som er den mest almindelige form for sygdommen. Det skyldes, i hvert fald delvist, at st\u00f8rstedelen af sAD-patienterne er \u00e6ldre mennesker, der ofte lider af en r\u00e6kke komorbiditeter (f.eks. slagtilf\u00e6lde, stress, diabetes, kramper, osteoporose og nyresygdom).<\/em><\/p>\n<\/blockquote>\n

Den n\u00e6ste infografik viser dannelsen af og mekanismerne bag synaptisk toksicitet af tau- og beta-amyloid-oligomerer.<\/p>\n

 <\/p>\n

\"infografico
Fra fortid til fremtid: Hvad dyremodeller har l\u00e6rt os om Alzheimers sygdom<\/figcaption><\/figure>\n

 <\/p>\n

\n

Under tauopatier er der en reduktion i antallet af dendritiske pigge. Tau kommer ikke ind i neuronets kerne, hvilket resulterer i DNA-skader. Der er en reduktion i antallet af mitokondrier og ogs\u00e5 i antallet af pr\u00e6synaptiske vesikler, hvilket f\u00f8rer til synaptisk tab. Dette tab skyldes ogs\u00e5, at tau tr\u00e6nger ind i dendritter og postsynaptiske omr\u00e5der. Tau aggregerer ogs\u00e5 ekstracellul\u00e6rt, s\u00e5 det kan indfanges af andre neuroner.<\/em><\/p>\n<\/blockquote>\n

 <\/p>\n

Hun har ogs\u00e5 lavet en infografik, der viser de inflammatoriske mekanismer, der er forbundet med Alzheimers sygdom (AD).<\/p>\n

 <\/p>\n

\"infografico<\/p>\n

 <\/p>\n

\n

I de seneste par \u00e5r har vi v\u00e6ret s\u00e6rligt interesserede i at forst\u00e5, hvordan inflammation p\u00e5virker beta-amyloid og tau-patologi. \u00c6ldre mennesker er modtagelige over for virus- og bakterieinfektioner, og disse mikrobielle stoffer kan forv\u00e6rre den eksisterende inflammatoriske tilstand i hjernen og fremskynde den kognitive tilbagegang.<\/em><\/p>\n<\/blockquote>\n

Tillykke Dr. Stefania Forner for dit store arbejde!<\/p>\n

Hvis du er forsker og gerne vil lave flotte figurer til din opgave, kan du blive mind the graph-bruger lige nu.<\/p>\n

\"untitled-creation63724<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Det er altid en fest, n\u00e5r vi ser vores brugeres fantastiske arbejde. Jeg har allerede skrevet om forskningen hos Dr. Alessandra Martini, Dr. Stefania Forner og deres kolleger. De er postdoktorale forskere ved University of California og har \u00f8je for grafbrugerne. For et par m\u00e5neder siden viste jeg den infografik, som Dr. Stefania Forner havde lavet til den oversigtsartikel, der blev offentliggjort i Trends [...]<\/p>","protected":false},"author":11,"featured_media":8067,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[195,958,957],"tags":[96,554],"yoast_head":"\nAlzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/da\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/da\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2018-08-23T18:56:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-18T11:30:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infographic-neuroscience.png\" \/>\n\t<meta property=\"og:image:width\" content=\"755\" \/>\n\t<meta property=\"og:image:height\" content=\"487\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabiola Soares\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabiola Soares\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog","description":"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/da\/alzheimers-sykdom\/","og_locale":"da_DK","og_type":"article","og_title":"Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog","og_description":"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.","og_url":"https:\/\/mindthegraph.com\/blog\/da\/alzheimers-sykdom\/","og_site_name":"Mind the Graph Blog","article_published_time":"2018-08-23T18:56:09+00:00","article_modified_time":"2022-10-18T11:30:53+00:00","og_image":[{"width":755,"height":487,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infographic-neuroscience.png","type":"image\/png"}],"author":"Fabiola Soares","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fabiola Soares","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/","url":"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/","name":"Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2018-08-23T18:56:09+00:00","dateModified":"2022-10-18T11:30:53+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/5592c012d89648325be9b0f3c3f91132"},"description":"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/#breadcrumb"},"inLanguage":"da-DK","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Alzheimer\u2019s disease: A scientific infographic"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"da-DK"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/5592c012d89648325be9b0f3c3f91132","name":"Fabiola Soares","image":{"@type":"ImageObject","inLanguage":"da-DK","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/7dca2c6a766aff1db898cc74c18284d8?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7dca2c6a766aff1db898cc74c18284d8?s=96&d=mm&r=g","caption":"Fabiola Soares"},"url":"https:\/\/mindthegraph.com\/blog\/da\/author\/fabiola\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/posts\/8064"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/comments?post=8064"}],"version-history":[{"count":14,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/posts\/8064\/revisions"}],"predecessor-version":[{"id":23414,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/posts\/8064\/revisions\/23414"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/media\/8067"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/media?parent=8064"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/categories?post=8064"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/tags?post=8064"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}