{"id":5346,"date":"2016-03-03T13:41:11","date_gmt":"2016-03-03T16:41:11","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=5346"},"modified":"2022-10-18T08:29:24","modified_gmt":"2022-10-18T11:29:24","slug":"zika-virus-graphical-abstract","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/da\/zika-virus-grafisk-abstrakt\/","title":{"rendered":"Zika-virus grafisk abstract om mikrocefali"},"content":{"rendered":"

Forst\u00e5 Zika-virus grafisk abstrakt: Hvordan det reducerer hjernens st\u00f8rrelse<\/h3>\n

I dag har et forskningsstudie tilf\u00f8jet interessante beviser for zikavirus' rolle i misdannelsen af nervev\u00e6v. Ah, ja, f\u00f8r du sp\u00f8rger, menneskeligt nervev\u00e6v.<\/p>\n

Dette blev elegant gjort af Dr. Stevens Rehens gruppe, en internationalt kendt forsker inden for stamcelleforskning og, for nylig, celleomprogrammering.<\/p>\n

Figuren nedenfor opsummerer resultaterne af papiret<\/a>Men jeg vil fors\u00f8ge at forklare det kort.<\/p>\n

 <\/p>\n

\"blog<\/p>\n

Dette indsigtsfulde grafiske abstrakt om zikavirus er lavet med Mind the graph. Er det ikke sejt?<\/em><\/p>\n

 <\/p>\n

 <\/p>\n

Som du kan se p\u00e5 billedet ovenfor, blev der anvendt tre forskellige tilgange i denne forskning. De bekr\u00e6fter alle, at zikavirus har en direkte indvirkning p\u00e5, hvordan hjerneceller udvikler sig til at danne et korrekt neuronalt v\u00e6v, ogs\u00e5 kaldet \"indbefatter hjernemisdannelse\".\"zika-virus<\/a>Mikrocefali er blot \u00e9n misdannelse i hjernen. Det, artiklen antyder, er noget endnu mere fundamentalt.<\/p>\n

De viser, hvordan zikavirus:<\/p>\n

    \n
  1. Fremmer celled\u00f8d<\/li>\n
  2. Fremkalder morfologiske \u00e6ndringer (i neurosf\u00e6rer)<\/li>\n
  3. Reducerer v\u00e6kst\/st\u00f8rrelse af cerebrale organoider (mini-hjerner)<\/li>\n<\/ol>\n

    Det er alle m\u00e5der, hvorp\u00e5 zikavirus p\u00e5virker neurogenesen under hjernens udvikling og for\u00e5rsager den f\u00e6notype, du ser nedenfor.<\/p>\n

    \"zika-virus<\/a><\/p>\n

    <\/h3>\n

    Hvorfor er det ikke blevet gjort f\u00f8r?<\/h3>\n

    Den banebrydende tilgang var brugen af inducerede pluripotente stamceller (iPS-celler) for at kunne studere virusinfektion i menneskeceller.<\/p>\n

    Med denne proces bliver en somatisk celle h\u00f8stet fra en person omprogrammeret til sin oprindelige tilstand som pluripotent celle og kan derefter differentieres til forskellige celler, v\u00e6v og p\u00e5 det seneste organer. Dette er selve begyndelsen p\u00e5 \"human tissue engineering\".<\/p>\n

    I unders\u00f8gelsen brugte forfatterne ikke kun iPS-celler, men genererede ogs\u00e5 Organoider i hjernen<\/a>, ogs\u00e5 kendt som \"mini-hjerner\", for at forst\u00e5, hvordan tilstedev\u00e6relsen af zikavirus p\u00e5virker dannelsen af dette neuronale v\u00e6v.<\/p>\n

    Cellekulturer som denne betragtes som tredimensionelle (3D) strukturer og giver flere hints om organarkitekturen. Dette er organoidens \u00e5r i henhold til \u00d8konom<\/a>. Ved hj\u00e6lp af denne innovative tilgang kunne forskerne forst\u00e5, hvordan zikavirus angriber menneskelige hjerneceller og reducerer deres levedygtighed og v\u00e6kst som neurosf\u00e6rer og cerebrale organoider.<\/p>\n

    Den papir<\/a> er p\u00e5 pre-print i det innovative tidsskrift PeerJ. Du kan endda kommentere og hj\u00e6lpe forfatterne med at forbedre det i l\u00f8bet af processen. Du kan se abstractet nedenfor og f\u00e5 fuld adgang ved at klikke p\u00e5 her<\/a>.<\/p>\n

    \"zika-virus<\/a><\/p>\n

    Note: To m\u00e5neder efter pre-printet p\u00e5 PeerJ i marts 2016 blev den endelige artikel udgivet, og til vores overraskelse var den udgivet p\u00e5 Science <\/a>Magazine, et af de mest prestigefyldte videnskabelige tidsskrifter i verden.<\/p>\n

    -> L\u00e6s hele artiklen af Garcez et al i Science <-<\/a><\/p>\n

    \"zika-virus<\/a><\/p>\n

    Lad flere mennesker vide det ved at dele dette indl\u00e6g. Dette er et sp\u00f8rgsm\u00e5l om global folkesundhed, som det allerede er sagt af Verdenssundhedsorganisationen<\/a>\u00a0(WHO).<\/p>\n

    \n

     <\/p>\n

    Vide, hvad WHO r\u00e5dgiver om zikavirus<\/a>\u00a0transmission og infektion:<\/p>\n

    \n

    Transmission<\/h3>\n

    Zikavirus overf\u00f8res prim\u00e6rt til mennesker gennem bid fra Aedes<\/i> myg, som ofte lever omkring bygninger i byomr\u00e5der og normalt er aktive i dagtimerne (den h\u00f8jeste stikaktivitet forekommer tidligt om morgenen og sent om eftermiddagen).<\/p>\n

    Noget tyder p\u00e5, at zikavirus ogs\u00e5 kan overf\u00f8res til mennesker gennem blodtransfusion, perinatal overf\u00f8rsel og seksuel overf\u00f8rsel. Disse m\u00e5der er dog meget sj\u00e6ldne.<\/p>\n

    Inkubationstiden er typisk mellem 2 og 7 dage.<\/p>\n

    Tegn og symptomer<\/h3>\n

    Zikavirusinfektion er karakteriseret ved lav feber (mindre end 38,5 \u00b0C), ofte ledsaget af et makulopapul\u00f8st udsl\u00e6t. Andre almindelige symptomer omfatter muskelsmerter, ledsmerter med mulig h\u00e6velse (is\u00e6r af de sm\u00e5 led i h\u00e6nder og f\u00f8dder), hovedpine, smerter bag \u00f8jnene og konjunktivitis. Da symptomerne ofte er milde, kan infektionen g\u00e5 ubem\u00e6rket hen eller blive fejldiagnosticeret som dengue.<\/p>\n

    Der forventes en h\u00f8j grad af asymptomatisk infektion med zikavirus, i lighed med andre flavivirus, s\u00e5som denguevirus og West Nile-virus. De fleste mennesker kommer sig helt uden alvorlige komplikationer, og antallet af hospitalsindl\u00e6ggelser er lavt. Til dato har der ikke v\u00e6ret rapporteret om d\u00f8dsfald i forbindelse med zikavirus.<\/p><\/blockquote>\n

     <\/p>\n

    Opdateret den 3. maj 2016.<\/p>","protected":false},"excerpt":{"rendered":"

    Forst\u00e5 Zika-virus grafisk abstrakt: Hvordan det reducerer hjernens st\u00f8rrelse I dag har et forskningsstudie tilf\u00f8jet interessante beviser for Zika-virus' rolle i misdannelsen af nervev\u00e6v. Ah, ja, f\u00f8r du sp\u00f8rger, menneskeligt nervev\u00e6v. Dette blev elegant gjort af Dr. Stevens Rehen, en internationalt kendt forsker inden for [...].<\/p>","protected":false},"author":4,"featured_media":7136,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[956],"tags":[96,201,200,203,202,205,554,71,250,204,199],"yoast_head":"\nZika virus graphical abstract on microcephaly - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This insightful Zika virus graphical abstract was done with Mind the graph. 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