{"id":16630,"date":"2022-09-08T18:14:00","date_gmt":"2022-09-08T21:14:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice-copy\/"},"modified":"2023-03-17T14:47:54","modified_gmt":"2023-03-17T17:47:54","slug":"success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/da\/succes-case-hojoploselig-synkrotron-baseret-rontgen-mikrotomografi-som-vaerktoj-til-at-afslore-hjernens-tre-dimensionelle-neuronale-arkitektur\/","title":{"rendered":"Synkrotronbaseret r\u00f8ntgenmikrotomografi i h\u00f8j opl\u00f8sning som et v\u00e6rkt\u00f8j til at afsl\u00f8re hjernens tredimensionelle neuronale arkitektur Paper Review"},"content":{"rendered":"

R\u00f8ntgenmikrotomografi er dukket op som en ny metode til at afkode hjernens cytoarkitektur og konnektivitet, og her pr\u00e6senterer vi en metode til at afbilde hele neuroner.<\/p>\n\n\n\n

Synkrotronbaseret r\u00f8ntgenmikrotomografi i h\u00f8j opl\u00f8sning som et v\u00e6rkt\u00f8j til at afsl\u00f8re hjernens tredimensionelle neuronale arkitektur<\/strong><\/h2>\n\n\n\n

I \"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain\" bem\u00e6rkede Matheus de Castro Fonseca et al. (2018), at studiet af neuroner som individualiserede enheder begyndte i det 19. \u00e5rhundrede med oprettelsen af neurondoktrinen. <\/p>\n\n\n\n

I de sidste par \u00e5r er der gjort en stor indsats for at forst\u00e5 neuronal organisation og konnektivitet i intakte hjernepr\u00f8ver. Golgi-Cox-m\u00e6rkningsteknikken giver en passende kontrast til den specifikke m\u00e6rkning af neuroner til r\u00f8ntgenmikrotomografi. <\/p>\n\n\n\n

Neuroner har en tydelig morfologi og specifikke forbindelsesm\u00f8nstre, som er afg\u00f8rende for, at de fungerer korrekt. Forskerne pr\u00e6senterer en metode til billeddannelse, der kombinerer synkrotronbaseret r\u00f8ntgenmikrotomografi med Golgi-Cox-impr\u00e6gneringsprotokollen. <\/p>\n\n\n\n

Metoden giver en h\u00f8jere og mere homogen kontrast af relativt tyndt fordelte hele neuroner i v\u00e6vet.<\/p>\n\n\n\n

Hjernerne blev inkuberet i Golgi-Cox-farvningsopl\u00f8sning i 14 dage, beskyttet mod lys. Efter inkubationsperioden blev hjernerne snittet i serier ved hj\u00e6lp af et vibratom.<\/strong><\/p>\n\n\n\n

Kontroller Originalartikel her<\/a>.<\/p>\n\n\n\n

Grafisk abstrakt drevet af Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
\n
\"\"<\/a>
Fremstillet med Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Forfatteren brugte Mind the Graph<\/a> til at skabe en skematisk illustration, der repr\u00e6senterer en voksen mus, der f\u00e5r en i.p.-injektion med saltvand eller pilocarpinopl\u00f8sning (280 mg\/kg). At repr\u00e6sentere komplekse processer med infografik er en god m\u00e5de at g\u00f8re dem letforst\u00e5elige p\u00e5, uden at man glemmer detaljerne og de vigtige oplysninger.<\/p>\n\n\n\n

Nogle af forskernes resultater ser ud til at konsolidere det, man tidligere vidste om dette omr\u00e5de: \"Den kviks\u00f8lvbaserede neuronimpr\u00e6gnering, vi viste her, gjorde det muligt for os klart at definere hele neuroner, hovedsageligt p\u00e5 grund af en mere kontinuerlig og homogen impr\u00e6gnering af cellerne og en meget reduceret t\u00e6thed af artefakter,\" foreslog de Castro Fonseca.<\/p>\n\n\n\n

Artiklernes effekt og ydeevne<\/strong><\/h2>\n\n\n\n

Vi kan analysere med Altmetric<\/a> data, at denne artikels online opm\u00e6rksomhedsscore er h\u00f8jere end 64%<\/strong><\/strong> af alle andre artikler af samme alder i Scientific Reports.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/a>
Kilde Altmetri<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

G\u00f8r ogs\u00e5 din artikel mere tilg\u00e6ngelig ved hj\u00e6lp af infografik.<\/p>\n\n\n\n

\n
Pr\u00f8v Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Se den nye metode til at dechifrere hjernens cytoarkitektur og konnektivitet repr\u00e6senteret med Mind the Graph's illustrationer.<\/p>","protected":false},"author":29,"featured_media":20013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nHigh-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/da\/succes-case-hojoploselig-synkrotron-baseret-rontgen-mikrotomografi-som-vaerktoj-til-at-afslore-hjernens-tre-dimensionelle-neuronale-arkitektur\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/da\/succes-case-hojoploselig-synkrotron-baseret-rontgen-mikrotomografi-som-vaerktoj-til-at-afslore-hjernens-tre-dimensionelle-neuronale-arkitektur\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-08T21:14:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_2.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog","description":"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/da\/succes-case-hojoploselig-synkrotron-baseret-rontgen-mikrotomografi-som-vaerktoj-til-at-afslore-hjernens-tre-dimensionelle-neuronale-arkitektur\/","og_locale":"da_DK","og_type":"article","og_title":"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog","og_description":"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.","og_url":"https:\/\/mindthegraph.com\/blog\/da\/succes-case-hojoploselig-synkrotron-baseret-rontgen-mikrotomografi-som-vaerktoj-til-at-afslore-hjernens-tre-dimensionelle-neuronale-arkitektur\/","og_site_name":"Mind the Graph Blog","article_published_time":"2022-09-08T21:14:00+00:00","article_modified_time":"2023-03-17T17:47:54+00:00","og_image":[{"width":1125,"height":614,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_2.jpg","type":"image\/jpeg"}],"author":"Artur Zignani","twitter_card":"summary_large_image","twitter_image":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_2.jpg","twitter_misc":{"Written by":"Artur Zignani","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/","url":"https:\/\/mindthegraph.com\/blog\/success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/","name":"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2022-09-08T21:14:00+00:00","dateModified":"2023-03-17T17:47:54+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/b44995c1d77b52a63b6d11262b740b02"},"description":"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/#breadcrumb"},"inLanguage":"da-DK","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"da-DK"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/b44995c1d77b52a63b6d11262b740b02","name":"Artur Zignani","image":{"@type":"ImageObject","inLanguage":"da-DK","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/a211ec97011fe24f7a8e63a7ca799342?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a211ec97011fe24f7a8e63a7ca799342?s=96&d=mm&r=g","caption":"Artur Zignani"},"url":"https:\/\/mindthegraph.com\/blog\/da\/author\/artur\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/posts\/16630"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/comments?post=16630"}],"version-history":[{"count":5,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/posts\/16630\/revisions"}],"predecessor-version":[{"id":27198,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/posts\/16630\/revisions\/27198"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/media\/20013"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/media?parent=16630"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/categories?post=16630"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/tags?post=16630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}