{"id":13008,"date":"2021-06-21T18:09:00","date_gmt":"2021-06-21T21:09:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=13008"},"modified":"2023-01-05T14:38:06","modified_gmt":"2023-01-05T17:38:06","slug":"napping-time-genetics","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/da\/genetik-for-lurtid\/","title":{"rendered":"Genetik for lurtid: Hvordan en lur kan p\u00e5virke den genetiske variation"},"content":{"rendered":"

En lur i l\u00f8bet af dagen er de fleste menneskers skyldige forn\u00f8jelse.<\/p>\n\n\n

\n
\"garfield<\/a><\/figure><\/div>\n\n\n

Det meste af tiden er det ogs\u00e5 en vane, der er indgroet i den daglige rutine. Det er meget almindeligt hos mange arter fra fluer til pattedyr.<\/p>\n\n\n\n

En lur er ogs\u00e5 med til at forbedre \u00e5rv\u00e5genheden, hvilket er vigtigt for dem, der arbejder sent om aftenen, eller dem, der normalt er i s\u00f8vnunderskud.<\/p>\n\n\n\n

Det siges ogs\u00e5 at kunne forbedre ens pr\u00e6stationsevne, hukommelse og lindre stress. <\/p>\n\n\n\n

Men bortset fra disse fordele kan de langsigtede konsekvenser af en lur v\u00e6re kroniske for den enkeltes velbefindende.<\/p>\n\n\n\n

Selvom det er et kontroversielt emne, og \u00e5rsagen kan skyldes flere faktorer, der er forbundet med at tage en lur, s\u00e5som utilstr\u00e6kkelig s\u00f8vncyklus, d\u00e5rlig kost eller d\u00e5rligt helbred.<\/p>\n\n\n\n

Er en lur i l\u00f8bet af dagen din happy hour? Forskere siger noget andet. <\/strong><\/p>\n\n\n\n

En gruppe forskere analyserede effekten af at tage en lur gennem genetiske variationer.<\/p>\n\n\n\n

Deres unders\u00f8gelse bestod i at forst\u00e5 den genetiske variation hos forskellige individer gennem deres pr\u00e6ferencer for varighed og pr\u00e6ferencer for lure.<\/p>\n\n\n\n

P\u00e5 nuv\u00e6rende tidspunkt har den genomomfattende associationsunders\u00f8gelse opdaget omkring syv genetiske loci, der svarer til lurtid i l\u00f8bet af dagen.<\/p>\n\n\n\n

Forskerne brugte UK Biobank-deltagere af europ\u00e6isk afstamning (n=452.633), hvoraf omkring 38,2% af deltagerne tog en lur nogle gange, og 5,3% af deltagerne tog altid en lur i l\u00f8bet af dagen.<\/p>\n\n\n\n

De, der tog en lur, var n\u00e6sten altid \u00e6ldre m\u00e6nd med h\u00f8jt BMI (body mass index), som var blevet diagnosticeret med s\u00f8vnforstyrrelser, var rygere eller pensionister. De gennemf\u00f8rte et GWAS-studie (genome-wide association study) med tildelte genetiske varianter af h\u00f8j kvalitet, der omfattede omkring fire lakh deltagere. Dette blev gjort ved at \u00e6ndre de forskellige faktorer, der var fundet tidligere.<\/p>\n\n\n\n

Det lykkedes dem at identificere 123 genetiske loci sammen med en enkelt nukleotidpolymorfisme-baseret arvelighed p\u00e5 ca. 11,9%.<\/p>\n\n\n\n

De indsn\u00e6vrede deres GWAS til personer med h\u00f8jere BMI. <\/p>\n\n\n\n

Det viste sig, at ud af 123 loci blev 110 tilbageholdt i genomisk signifikans.<\/p>\n\n\n\n

De analyserede ogs\u00e5 forskellen p\u00e5 lurem\u00f8nstrene hos de forskellige k\u00f8n i forbindelse med X-kromosomet. <\/p>\n\n\n\n

Derudover konkluderede de ogs\u00e5 p\u00e5 gener, der var ansvarlige for fedmehypersomnolensvejen: PNOC (pr\u00e6pronociceptin), <\/em>og PATJ (krummecellepolaritetskomponent).<\/em><\/p>\n\n\n\n

Desuden viste ekspressionen af FADS1-genet (Fatty Acid Desaturase), der var koloniseret, en pleiotropisk effekt af lipidmetabolismen p\u00e5 s\u00f8vnm\u00f8nsteret.<\/p>\n\n\n\n

De andre korrelationer blev opfattet i forhold til den genomd\u00e6kkende genetik sammen med tr\u00e6k som det glyk\u00e6miske indeks, antropometrisk samt kardiometabolisk, hvoraf mange korrelationer blev reduceret efter at have taget h\u00f8jde for BMI. <\/p>\n\n\n\n

Hvad mere er, er, at den score, der blev analyseret af phenome-wide association ved hj\u00e6lp af daytime napping genome-wide polygenic, bidrog til korrelationen mellem sygdomme relateret til fedme, hypertension og vigtigst af alt ogs\u00e5 visse kardiometaboliske sygdomme. <\/p>\n\n\n\n

Konklusionen er, at deres resultater er en \u00f8jen\u00e5bner. Nogle gange er det s\u00e5danne vaner, der f\u00f8rer til flere u\u00f8nskede komplikationer i vores kroppe. Man skal f\u00f8lge en sund rutine og en god livsstil. <\/p>\n\n\n

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\"mand<\/a><\/figure><\/div>\n\n\n

Hvis du vil vide mere om deres forskning, kan du tjekke referencen nedenfor.<\/p>\n\n\n\n

Dashti, H.S., Daghlas, I., Lane, J.M. et al.<\/em> Genetiske determinanter for lur i dagtimerne og effekter p\u00e5 kardiometabolisk sundhed. Nat Commun<\/em> 12, 900 (2021). DOI: https:\/\/doi.org\/10.1038\/s41467-020-20585-3<\/a><\/p>\n\n\n\n

I Mind the Graph Gallery kan du finde mange genetik-relaterede illustrationer. Klik p\u00e5 billedet nedenfor for at se det.<\/p>\n\n\n

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\"\"\/<\/a><\/figure><\/div>","protected":false},"excerpt":{"rendered":"

En lur i l\u00f8bet af dagen er de fleste menneskers skyldige forn\u00f8jelse. Det meste af tiden er det ogs\u00e5 en vane, der er indgroet i den daglige rutine. Det er meget almindeligt hos mange arter fra fluer til pattedyr. En lur er ogs\u00e5 med til at forbedre opm\u00e6rksomheden, hvilket er vigtigt for dem, der arbejder sent om aftenen, eller dem, der er [...].<\/p>","protected":false},"author":18,"featured_media":13012,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nDid you know that taking that nap can influence genetic - MTG<\/title>\n<meta name=\"description\" content=\"Is napping time your happy hour? 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