{"id":12192,"date":"2021-01-27T10:46:16","date_gmt":"2021-01-27T12:46:16","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12192"},"modified":"2023-01-05T14:40:18","modified_gmt":"2023-01-05T17:40:18","slug":"cannabis-and-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/da\/cannabis-og-alzheimers-sygdom\/","title":{"rendered":"Hvad findes der om cannabis og Alzheimers sygdom?"},"content":{"rendered":"
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Alzheimers sygdom (AD) er en neurodegenerativ sygdom, der er ansvarlig for mere end 50% af de demenstilf\u00e6lde, der diagnosticeres i \u00f8jeblikket, og den er direkte korreleret med aldring. I dag har 40% af mennesker over 85 \u00e5r en eller anden grad af demens.<\/p>\n\n\n\n

Tidligere troede man, at AD-symptomer kun var relateret til en forringet kognitiv funktion, der p\u00e5virkede korttidshukommelsen, mens det i fremskredne stadier af sygdommen p\u00e5virker patientens sproglige evner og endda langtidshukommelsen.<\/p>\n\n\n\n

Men i dag ved man, at patienter, der lider af Alzheimers, udviser en r\u00e6kke andre symptomer som depression, psykose og aggressiv adf\u00e6rd, hvilket g\u00f8r sygdommen endnu v\u00e6rre. <\/p>\n\n\n\n

I de senere \u00e5r har forskere og l\u00e6ger i deres unders\u00f8gelser rapporteret om positive resultater, n\u00e5r de begynder at behandle deres AD-patienter med cannabisbaserede l\u00e6gemidler og opn\u00e5r symptomlindring.<\/p>\n\n\n\n

Det endocannabinoide system er blevet en alternativ tilgang til behandling af forskellige sygdomme og patologier, bortset fra dets indflydelse p\u00e5 adskillige processer som neuroplasticitet, neuroinflammation, adf\u00e6rdsforstyrrelser, s\u00f8vnregulering, immunologiske funktioner, inflammatoriske sygdomme, kardiovaskul\u00e6re funktioner, smerte, motorisk kontrol, energibalance og appetit. <\/p>\n\n\n\n

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Foto af Ravi Patel<\/a> p\u00e5 Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

Desv\u00e6rre er der stadig kun f\u00e5 officielle unders\u00f8gelser, der direkte analyserer forholdet mellem det endocannabinoide system og Alzheimers.<\/p>\n\n\n\n

I dag er det velkendt, at Alzheimers er for\u00e5rsaget af genetiske og aldringsm\u00e6ssige faktorer. De vigtigste syndere i sygdommen tilskrives de senile plaques<\/strong> og den neurofibrill\u00e6rt sammenfiltret<\/strong>. <\/p>\n\n\n\n

Et interessant faktum er, at forskere ved hj\u00e6lp af AD-rottemodeller opdagede, at AD-hjerner har et lavere antal CB1-receptorer sammenlignet med raske hjerner - f\u00e6rre CB1-receptorer kan i sidste ende mindske den terapeutiske virkning af l\u00e6gemidlet.<\/p>\n\n\n\n

Behandling med cannabinoider kan have en beskyttende virkning mod oxidativt stress og neuroinflammation i hjernen hos patienter med Alzheimers sygdom, hvilket hj\u00e6lper med at reducere dannelsen af amyloide plaques og neurofibrill\u00e6re tangles - og dermed forsinke patienternes kognitive forfald. <\/p>\n\n\n\n

Selvom amyloide plaques ogs\u00e5 kan findes i raske hjerner, er deres hyppighed ekstremt lavere sammenlignet med AD-hjerner.<\/p>\n\n\n\n

Unders\u00f8gelser, der er dedikeret til at forst\u00e5, hvorfor cannabinoider har en terapeutisk effekt p\u00e5 AD-patienter, opdagede, at THC-molekylet har evnen til at \u00f8ge biotilg\u00e6ngeligheden af en neurotransmitter kaldet acetylkolin<\/strong> (Ach) ved at h\u00e6mme enzymet, der nedbryder det. acetylcholinesterase<\/strong> (AChE) - Ach er hovedsageligt ansvarlig for at sende nerveimpulsen videre til den n\u00e6ste neuron. <\/p>\n\n\n\n

Enzymet AChE i en sund hjerne har til opgave at nedbryde Ach, men i en hjerne med Alzheimers sygdom er enzymet st\u00e6rkt til stede og nedbryder meget mere Ach, end det skal, hvilket for\u00e5rsager en forringelse af hjernens kognitive funktion over tid.   <\/p>\n\n\n\n

Forskere rapporterede, at cannabinoider kan hj\u00e6lpe p\u00e5 grund af deres h\u00e6mmende virkning p\u00e5 enzymet AChE - det har vist sig at give bedre resultater end andre kommercielt tilg\u00e6ngelige l\u00e6gemidler. <\/p>\n\n\n\n

THC kan ogs\u00e5 hj\u00e6lpe med at reducere adf\u00e6rdsforstyrrelser og regulere d\u00f8gnrytmen hos patienter med sv\u00e6r demens. Nogle forskere h\u00e6vder endda, at cannabinoiderne THC og CBD har potentiale til at v\u00e6re anti-Alzheimer-behandlinger.<\/p>\n\n\n\n

En artikel udgivet i 2015 i tidsskriftet Clinical Pharmacology and Therapeutics<\/a>giver et overblik over cannabinoiders potentiale i behandlingen af sent debuterende Alzheimers sygdom og relaterede neuropsykiatriske symptomer hos \u00e6ldre mennesker, og diskuterer ogs\u00e5 aspekter af cannabisbaserede l\u00e6gemidler i forhold til deres effektivitet, sikkerhed og farmakokinetik.<\/p>\n\n\n\n

En 72-\u00e5rig mand med Alzheimers sygdom havde en adf\u00e6rdsforstyrrelse i form af uro og aggressivitet. Hans tidligere behandling viste ingen signifikant forbedring. <\/p>\n\n\n\n

Da patienten blev introduceret til Nabilone - et syntetisk THC-l\u00e6gemiddel - viste han hurtigt forbedringer i sin adf\u00e6rdsforstyrrelse og andre symptomer, og han havde desuden ingen bivirkninger under behandlingen med THC-basemedicin.<\/p>\n\n\n\n

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Foto af Louis Reed<\/a> p\u00e5 Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

En anden unders\u00f8gelsesgruppe best\u00e5ende af femten patienter med Alzheimers sygdom - med en gennemsnitsalder p\u00e5 72 \u00e5r - viste f\u00f8r behandlingen adf\u00e6rdsforstyrrelser og problemer med at spise. <\/p>\n\n\n\n

De femten patienter blev behandlet i seks uger med dronabinol - ogs\u00e5 kendt som Marinol - et syntetisk THC-l\u00e6gemiddel. <\/p>\n\n\n\n

Efter en periode med behandling viste de en forbedring i adf\u00e6rd, v\u00e6gtfor\u00f8gelse og et fald i agitation - sammenlignet med placebo. Nogle bivirkninger blev bem\u00e6rket, s\u00e5som tr\u00e6thed, d\u00f8sighed og eufori, som alle er bekr\u00e6ftet at v\u00e6re forbundet med dronabinol.<\/p>\n\n\n\n

En anden gruppe p\u00e5 seks patienter med en gennemsnitsalder p\u00e5 81 \u00e5r, hvoraf nogle havde Alzheimers og andre led af sv\u00e6r demens, startede en to ugers behandling med dronabinol. <\/p>\n\n\n\n

Resultaterne viste en betydelig forbedring af disse patienters natlige motoriske aktiviteter og bedre adf\u00e6rd. I denne gruppe blev der ikke observeret nogen bivirkninger.<\/p>\n\n\n\n

I en anden unders\u00f8gelsesgruppe p\u00e5 40 patienter med forskellige grader af demens og med 13 af dem med Alzheimers sygdom. <\/p>\n\n\n\n

Alle blev introduceret til behandling med dronabinol for at behandle adf\u00e6rdsproblemer og appetitforstyrrelser. <\/p>\n\n\n\n

Behandlingsperioden var 17 dage, og patienterne fik det bedre i begge henseender. Bivirkninger som sedation, delirium, urinvejsinfektioner og forvirring blev rapporteret, men if\u00f8lge forskerne var disse ikke direkte forbundet med brugen af dronabinol.<\/p>\n\n\n\n

P\u00e5 trods af flere unders\u00f8gelser, der viser positive resultater ved brug af cannabinoider i behandlingen af patienter med demens, h\u00e6vder nogle forskere, at der stadig ikke er tilstr\u00e6kkelig dokumentation for, at cannabinoider virkelig er gode og sikre til behandling af adf\u00e6rdsforstyrrelser og demens.<\/p>\n\n\n\n

Under alle omst\u00e6ndigheder har forskere i stigende grad rapporteret om brugen af cannabisbaserede l\u00e6gemidler til behandling af patienter med Alzheimers, og ikke nok med det, det er ogs\u00e5 blevet brugt til behandling af Parkinsons sygdom og autisme, hvor l\u00e6ger og forskere rapporterer om forbedring af deres patienters livskvalitet, efter at de er begyndt at tage cannabisbaserede l\u00e6gemidler. Men det er et emne for den n\u00e6ste artikel.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

Er du fra det neurologiske omr\u00e5de? I Mind the Graph er der en stor kategori med neurologiske illustrationer, hvor du kan finde alt, hvad du har brug for til din neurologiske opgave eller pr\u00e6sentation. Tjek ud her<\/a>.  <\/strong><\/p>\n\n\n\n

Eller <\/strong>du leder efter Biokemi <\/a>og molekyl\u00e6rbiologi<\/a> illustrationer kan du ogs\u00e5 finde i Mind the Graph. <\/p>\n\n\n\n

Og vi er her for at hj\u00e6lpe dig, hvis du har brug for noget andet. Log ind p\u00e5 din konto<\/a> og send os en besked i ANMOD OM ET IKON<\/strong>. <\/p>\n\n\n\n

Referencer<\/strong><\/p>\n\n\n\n

AHMED, A. I. A. et al. Cannabinoider ved sent debuterende Alzheimers sygdom. Klinisk farmakologi og terapi<\/strong>, v. 97, n. 6, s. 597-606, 2015.<\/p>\n\n\n\n

AHMED, A. I. A. et al. Cannabinoider ved sent debuterende Alzheimers sygdom. Klinisk farmakologi og terapi<\/strong>, v. 97, n. 6, s. 597-606, 2015.<\/p>\n\n\n\n

BALASH, Y. et al. Medicinsk cannabis ved Parkinsons sygdom: Patienters erfaringer fra det virkelige liv. Klinisk neurofarmakologi<\/strong>, v. 40, n. 6, p. 268-272, dez. 2017.<\/p>\n\n\n\n

BENITO, C. et al. Det endocannabinoide system og Alzheimers sygdom. Molekyl\u00e6r neurobiologi<\/strong>, v. 36, n. 1, s. 75-81, 1 ago. 2007.<\/p>\n\n\n\n

DE FARIA, S. M. et al. Virkninger af akut cannabidioladministration p\u00e5 angst og rystelser fremkaldt af en simuleret offentlig taletest hos patienter med Parkinsons sygdom. Tidsskrift for psykofarmakologi<\/strong>, v. 34, n. 2, s. 189-196, 1 fev. 2020.<\/p>\n\n\n\n

FALCO, A. D. et al. DOEN\u00c7A DE ALZHEIMER: HIP\u00d3TESES ETIOL\u00d3GICAS E PERSPECTIVAS DE TRATAMENTO. Qu\u00edmica Nova<\/strong>, v. 39, n. 1, s. 63-80, jan. 2016.<\/p>\n\n\n\n

LEEHEY, M. A. et al. Sikkerhed og tolerabilitet af cannabidiol ved Parkinsons sygdom: Et \u00e5bent, dosis-eskaleringsstudie. Forskning i cannabis og cannabinoider<\/strong>, 19 mar. 2020.<\/p>\n\n\n\n

POLEG, S. et al. Cannabidiol som en foresl\u00e5et kandidat til behandling af autismespektrumforstyrrelser. Fremskridt inden for neuro-psykofarmakologi og biologisk psykiatri<\/strong>, v. 89, s. 90-96, 8 mar. 2019.YOO, K.-Y.; PARK, S.-Y. Terpenoider som potentielle terapeutika mod Alzheimers sygdom. Molekyler<\/strong>, v. 17, n. 3, s. 3524-3538, mar. 2012.<\/p>","protected":false},"excerpt":{"rendered":"

Alzheimers sygdom (AD) er en neurodegenerativ sygdom, der er ansvarlig for mere end 50% af de demenstilf\u00e6lde, der diagnosticeres i \u00f8jeblikket, og den er direkte korreleret med aldring. I dag har 40% af mennesker over 85 \u00e5r en eller anden grad af demens. Tidligere troede man, at AD-symptomer kun var relateret til et fald i kognitionsfunktionen, der p\u00e5virkede korttidshukommelsen, men i [...]<\/p>","protected":false},"author":4,"featured_media":12193,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959],"tags":[213,819,554],"yoast_head":"\nWhat is Out There About Cannabis and Alzheimer\u2019s Disease - MTG<\/title>\n<meta name=\"description\" content=\"Do you know Cannabis and Alzheimer's Disease can be related? 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He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. 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