{"id":11793,"date":"2020-10-15T05:06:00","date_gmt":"2020-10-15T08:06:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=11793"},"modified":"2022-11-21T09:55:34","modified_gmt":"2022-11-21T12:55:34","slug":"nobel-prize-2020-for-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/da\/nobelprisen-2020-for-medicin\/","title":{"rendered":"Nobelprisen i medicin 2020 - Opdagelse, diagnosticering og helbredelse af hepatitis C"},"content":{"rendered":"

I en af \u00e5rets globale videnskabelige benchmark-begivenheder i Stockholm den 5. oktober 2020 blev Nobelprisen i fysiologi eller medicin tildelt en gruppe virologer og biokemikere for opdagelsen af hepatitis C-virus. Harvey Alter, Michael Houghton og Charles Rice tildeles Nobelprisen i f\u00e6llesskab for at have opdaget det for\u00e5rsagende stof og fundet en vej til helbredelse af sygdommen. Medlemmerne af Nobelforsamlingen p\u00e5 Karolinska Instituttet kunne ikke holde sig tilbage med at sige, at denne opdagelse er et h\u00e5b om at udrydde blodb\u00e5ren hepatitis fra verden.<\/span><\/p>\n

I en af \u00e5rets globale videnskabelige benchmark-begivenheder i Stockholm den 5. oktober 2020 blev Nobelprisen i fysiologi eller medicin tildelt en gruppe virologer og biokemikere for opdagelsen af hepatitis C-virus. Harvey Alter, Michael Houghton og Charles Rice tildeles Nobelprisen i f\u00e6llesskab for at have opdaget det for\u00e5rsagende stof og fundet en vej til helbredelse af sygdommen. Medlemmerne af Nobelforsamlingen p\u00e5 Karolinska Instituttet kunne ikke holde sig tilbage med at sige, at denne opdagelse er et h\u00e5b om at udrydde blodb\u00e5ren hepatitis fra verden.<\/span><\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

Hvad er hepatitis?<\/b><\/h2>\n

Ordet hepatitis stammer fra det gr\u00e6ske ord \"Hepar\", der henviser til leveren. Hepatitis er en medicinsk tilstand, hvor leveren hos en person er bet\u00e6ndt p\u00e5 grund af enten forgiftning eller virusinfektion. Hepatitis er karakteriseret ved gulsot, skrumpelever, feber og forst\u00f8rret lever. Blandt de smitstoffer, der er ansvarlige for hepatitis, overf\u00f8res hepatitis A-virus gennem forurenet vand, mens B og C overf\u00f8res gennem blod og kropsv\u00e6sker.<\/span><\/p>\n

Hvordan blev det opdaget?<\/b><\/h2>\n

Efter opdagelsen af hepatitis B havde Alter og hans team observeret flere uforklarlige leverinfektioner og kronisk hepatitis efter blodtransfusion. I deres efterf\u00f8lgende studier beviste de to vigtige fakta: For det f\u00f8rste kunne det ukendte smitstof overf\u00f8re sygdommen til chimpanser, og for det andet havde smitstoffet karakteristika som en virus, men ikke som hepatitis A eller B. Alters bidrag til virologien tjente som lys i den m\u00f8rke stormfulde nat med tilf\u00e6lde af leverinfektioner. Alligevel blev virussen ikke identificeret og ikke karakteriseret af nogen virusfamilie og ikke klassificeret.<\/span><\/p>\n

Bidrag til identifikation og vej til udryddelse<\/b><\/h2>\n

Med h\u00f8j sygelighed og d\u00f8delighed har forskere i \u00e5renes l\u00f8b v\u00e6ret ivrige efter at identificere det for\u00e5rsagende middel til \"ukendt\" hepatitis-lignende virus og karakterisere det. Efter at have fors\u00f8gt alle traditionelle teknikker uden held, kunne de med Houghtons innovative tilgang hos Chiron Pharmaceuticals identificere og klone DNA-fragmenter, der var ansvarlige for dannelsen af virale proteiner. Efter en omfattende forberedelse af DNA-biblioteket og s\u00f8gning efter klonen kunne Houghton og hans team endelig identificere ligheden med Flaviviridae-familien og navngive den Hepatitis C-virus. Deres forskning gav ogs\u00e5 en testprocedure til at identificere det for\u00e5rsagende middel med antistoffer, der blev identificeret.<\/span><\/p>\n

\"\"<\/a><\/p>\n

Det endelige bevis p\u00e5, at hepatitis C kunne v\u00e6re den eneste ansvarlige \u00e5rsag til leverinfektion, var et resultat af omfattende forskning udf\u00f8rt af Rice p\u00e5 Washington University i St. Ved hj\u00e6lp af rekombinant DNA-teknologi genererede Rice og hans team en genomisk variant af hepatitis C-virus, som ikke havde inaktiverende sekvenser, og injicerede den i primater. Resultaterne indikerede, at varianterne kunne f\u00f8re til kronisk leversygdom og afspejlede alle patologiske forandringer. Med alle de nyligt identificerede sekvenser og inaktiverende regioner gav de h\u00e5b om at skabe det rette terapeutiske middel mod hepatitis C-virus.<\/span><\/p>\n

Opdagelsens betydning<\/b><\/h2>\n

Verden er blevet en krigsfront med COVID-19-pandemien. Med opdagelsen af antivirale l\u00e6gemidler, diagnostik og identifikation er Hepatitis C og relaterede resultater bem\u00e6rkelsesv\u00e6rdige fodspor inden for virologi og medicin. Verdenssundhedsorganisationen har sat sig som m\u00e5l at udrydde hepatitis C-virus inden for ti \u00e5r fra nu. Disse opdagelser er springbr\u00e6t til dette m\u00e5l. Der er dog stadig udfordringer, der skal overvindes, og der er endnu ikke lavet en vaccine, men der er kommet et glimt af h\u00e5b i form af detektions- og behandlingsregimer til at bek\u00e6mpe sygdommen.<\/span><\/p>\n

Mind the Graph-teamet \u00f8nsker trioen af forskere, universiteter og deres grupper tillykke med deres pr\u00e6station! \u00c5rtiers forskning og h\u00e5rdt arbejde har givet menneskeheden en ny vej til at besejre en d\u00f8delig virussygdom.<\/span><\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11817,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nNobel Prize in Medicine 2020 - Diagnosis and Cure of Hepatitis C<\/title>\n<meta name=\"description\" content=\"The recent findings in Hepatitis C have been acclaimed for the Nobel Prize in 2020 in Chemistry. Read this post to know more about what it is!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/da\/nobelprisen-2020-for-medicin\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nobel Prize in Medicine 2020 - Diagnosis and Cure of Hepatitis C\" \/>\n<meta property=\"og:description\" content=\"The recent findings in Hepatitis C have been acclaimed for the Nobel Prize in 2020 in Chemistry. Read this post to know more about what it is!\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/da\/nobelprisen-2020-for-medicin\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-15T08:06:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-11-21T12:55:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2020\/10\/nobel-prize-2020-for-medicine.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1110\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabricio Pamplona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabricio Pamplona\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Nobel Prize in Medicine 2020 - Diagnosis and Cure of Hepatitis C","description":"The recent findings in Hepatitis C have been acclaimed for the Nobel Prize in 2020 in Chemistry. Read this post to know more about what it is!","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/da\/nobelprisen-2020-for-medicin\/","og_locale":"da_DK","og_type":"article","og_title":"Nobel Prize in Medicine 2020 - Diagnosis and Cure of Hepatitis C","og_description":"The recent findings in Hepatitis C have been acclaimed for the Nobel Prize in 2020 in Chemistry. Read this post to know more about what it is!","og_url":"https:\/\/mindthegraph.com\/blog\/da\/nobelprisen-2020-for-medicin\/","og_site_name":"Mind the Graph Blog","article_published_time":"2020-10-15T08:06:00+00:00","article_modified_time":"2022-11-21T12:55:34+00:00","og_image":[{"width":1110,"height":600,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2020\/10\/nobel-prize-2020-for-medicine.png","type":"image\/png"}],"author":"Fabricio Pamplona","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fabricio Pamplona","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/nobel-prize-2020-for-medicine\/","url":"https:\/\/mindthegraph.com\/blog\/nobel-prize-2020-for-medicine\/","name":"Nobel Prize in Medicine 2020 - Diagnosis and Cure of Hepatitis C","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2020-10-15T08:06:00+00:00","dateModified":"2022-11-21T12:55:34+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3"},"description":"The recent findings in Hepatitis C have been acclaimed for the Nobel Prize in 2020 in Chemistry. Read this post to know more about what it is!","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/nobel-prize-2020-for-medicine\/#breadcrumb"},"inLanguage":"da-DK","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/nobel-prize-2020-for-medicine\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/nobel-prize-2020-for-medicine\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Nobel Prize 2020 for Medicine – Discovery, Diagnosis, and Cure of Hepatitis C"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"da-DK"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3","name":"Fabricio Pamplona","image":{"@type":"ImageObject","inLanguage":"da-DK","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","caption":"Fabricio Pamplona"},"description":"Fabricio Pamplona is the founder of Mind the Graph - a tool used by over 400K users in 60 countries. He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. Connect with him on LinkedIn - Fabricio Pamplona.","sameAs":["http:\/\/mindthegraph.com","https:\/\/www.linkedin.com\/in\/fabriciopamplona"],"url":"https:\/\/mindthegraph.com\/blog\/da\/author\/fabricio\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/posts\/11793"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/comments?post=11793"}],"version-history":[{"count":4,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/posts\/11793\/revisions"}],"predecessor-version":[{"id":16085,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/posts\/11793\/revisions\/16085"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/media\/11817"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/media?parent=11793"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/categories?post=11793"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/da\/wp-json\/wp\/v2\/tags?post=11793"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}