{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/da\/coronavirus-covid-19-er-hydroxyklorokin-det-nye-hab-sa-klart-ja\/","title":{"rendered":"Coronavirus (Covid-19): Er hydroxychloroquin det nye h\u00e5b? Tilsyneladende, ja."},"content":{"rendered":"

To nylige artikler, der opsummerede en in vitro-forskning og et mindre klinisk studie, var nok for Donald Trump til at f\u00e5 FDA til at h\u00e5ndh\u00e6ve en ny klinisk indikation for hydroxychloroquin: forbedring af symptomer hos patienter, der er ramt af coronavirus (Covid-19).<\/p>\n

Det er sandsynligvis den hurtigste godkendelsesproces for et l\u00e6gemiddel i moderne tid, og pr\u00e6sidenten har tilsyneladende ret. Overraskende for en global leder, der ikke har meget til overs for videnskab.<\/p>\n

\"\"<\/p>\n

De f\u00f8rste beviser p\u00e5 hydroxychloroquins virkning p\u00e5 virussen kom fra Denne artikel blev offentliggjort i g\u00e5r p\u00e5 Cell Discovery<\/a>Det er kun in vitro, med alle de begr\u00e6nsninger det indeb\u00e6rer, men det viser tydeligt l\u00e6gemidlets potentiale til at dr\u00e6be virussen. Da de indsendte artiklen, var 80.000 tilf\u00e6lde bekr\u00e6ftet i Kina, herunder 2946 d\u00f8dsfald samt over 10.566 bekr\u00e6ftede tilf\u00e6lde i 72 andre lande. P\u00e5 det tidspunkt var det st\u00f8rste h\u00e5b knyttet til et l\u00e6gemiddel kaldet remdesivir.<\/p>\n

\"in
In vitro-effekter af hydrochloroquin p\u00e5 coronavirus (Covid-19). S\u00f8jlen til h\u00f8jre viser effekten af det effektive l\u00e6gemiddel i mods\u00e6tning til klorokin eller kontrolgruppen til venstre. Det viser, at l\u00e6gemidlet forbedrede cellernes evne til at udst\u00f8de virusserne... det er som at hj\u00e6lpe med at smide en u\u00f8nsket nabo ud af dit hus. Det hj\u00e6lper! \ud83d\ude42. <\/figcaption><\/figure>\n

Men den st\u00f8rste nyhed kom fra et mindre klinisk studie, som blev offentliggjort dagen f\u00f8r. Titlen er Hydroxychloroquin og azithromycin som behandling af COVID-19: resultater af et \u00e5bent ikke-randomiseret klinisk fors\u00f8g og kan downloades i sin \"in press\"-version<\/a><\/p>\n

I en unders\u00f8gelse med kun 20 patienter viste forfatterne, at hydroxychloroquin var effektivt mod coronavirus Covid-19-infektionen. Faktisk reducerede det 75% af inficerede individer i en periode p\u00e5 6 dage, hvilket er fantastisk. Endnu bedre var det, at kombinationen med azithromycin forbedrede behandlingseffekten til 95%.<\/p>\n

\"Kombineret
Kombineret behandling med hydrochloroquin og azithromycin er effektiv mod infektioner med coronavirus (Covid-19) hos mennesker. Faldet er dramatisk og giver nyt h\u00e5b til de ramte patienter.<\/figcaption><\/figure>\n

Behandlingen forbedrede symptomerne og reducerede samtidig virusm\u00e6ngden hos patienterne. L\u00e6gemidlet er tidligere blevet godkendt til malaria, hvilket betyder, at det betragtes som sikkert. \"S\u00f8stermedicinen\" chloroquin var mindre effektiv. Det er godt for os, for det er langt mere giftigt.<\/p>\n

Unders\u00f8gelsen var ikke-randomiseret og i lille skala, men det ser ud til, at selvom epidemien startede i Kina, kommer l\u00f8sningen fra en global indsats. In vitro-artiklen er faktisk kinesisk, mens den kliniske er europ\u00e6isk, n\u00e6rmere bestemt fra Frankrig. Interessant nok er den oprindelige registrering af hydroxychloroquin fra det franske medicinalfirma Sanofi, og det seneste kliniske studie blev udf\u00f8rt i Marseille. Ale le bleu!<\/p>\n

Medscape har en fremragende artikel om det for dem, der er interesseret i mere detaljerede oplysninger.<\/a><\/p>\n

Citer venligst dette arbejde som Gautret et al (2020) Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. International Journal of Antimicrobial Agents - I trykken 17. marts 2020 - DOI : 10.1016\/j.ijantimicag.2020.105949<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"\nCoronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. 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