{"id":9012,"date":"2019-06-03T11:07:17","date_gmt":"2019-06-03T14:07:17","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=9012"},"modified":"2022-10-18T08:23:58","modified_gmt":"2022-10-18T11:23:58","slug":"award-zika-virus-infection","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/cs\/oceneni-zika-virus-infekce\/","title":{"rendered":"Virus Zika: Ocen\u011bn\u00e1 studie, kter\u00e1 p\u0159in\u00e1\u0161\u00ed nov\u00e9 poznatky o dlouhodob\u00fdch d\u016fsledc\u00edch onemocn\u011bn\u00ed."},"content":{"rendered":"

Je v\u017edy \u00fa\u017easn\u00e9 uk\u00e1zat v\u011bdeckou pr\u00e1ci na\u0161ich u\u017eivatel\u016f. Dnes v\u00e1m tedy p\u0159edstav\u00edm brazilskou v\u011bdkyni Isis de Souza a jej\u00ed pr\u00e1ci s virem zika. Isis a jej\u00ed kolegov\u00e9 studuj\u00ed dopad infekce virem zika v ran\u00e9m v\u011bku u my\u0161\u00ed. Isis je tak\u00e9 u\u017eivatelkou programu Mind the graph a v\u00edt\u011bzn\u00e1 prezentace obsahuje vizu\u00e1ln\u00ed zdroje z programu Mind the graph. Nemohli bychom b\u00fdt v\u00edce hrd\u00ed.<\/p>\n

Co je virus zika?<\/strong><\/h3>\n

Virus Zika pat\u0159\u00ed do \u010deledi Flaviviridae. Tato skupina zahrnuje n\u011bkolik patogenn\u00edch vir\u016f. Nejzn\u00e1m\u011bj\u0161\u00ed je virus \u017elut\u00e9 zimnice, kter\u00fd je typem viru pro tuto \u010dele\u010f a tak\u00e9 d\u016fvodem n\u00e1zvu \u010deledi, proto\u017ee slovo flavus znamen\u00e1 v latin\u011b \"\u017elut\u00fd\". Krom\u011b n\u011bj pat\u0159\u00ed mezi dal\u0161\u00ed flaviviry virus z\u00e1padonilsk\u00e9 hore\u010dky, virus hore\u010dky dengue a virus kl\u00ed\u0161\u0165ov\u00e9 encefalitidy.<\/p>\n

\u010cele\u010f Flaviviridae m\u00e1 spole\u010dnou velikost (40-65 nm) a virov\u00e9 obaly, kter\u00e9 pokr\u00fdvaj\u00ed jejich ochrann\u00fd ikosaedrick\u00fd nukleokapsid. Tak\u00e9 jejich genetick\u00fdm materi\u00e1lem je RNA a objevuj\u00ed se v elektronov\u00e9m mikroskopu.<\/p>\n

N\u00ed\u017ee uveden\u00e1 infografika ukazuje z\u00e1kladn\u00ed strukturu viru zika:<\/p>\n

\"n\u00e1hled_90481\"<\/a><\/p>\n

 Zika se \u0161\u00ed\u0159\u00ed p\u0159edev\u0161\u00edm sami\u010dkami Stegomya aegypti<\/em> kom\u00e1r, kter\u00fd pot\u0159ebuje krev, aby mohl nakl\u00e1st vaj\u00ed\u010dka. Kom\u00e1r je aktivn\u00ed p\u0159ev\u00e1\u017en\u011b ve dne.<\/p>\n

V\u00edt\u011bzn\u00fd pap\u00edr<\/strong><\/h2>\n

V posledn\u00ed dob\u011b se \u0159ada v\u011bdc\u016f zab\u00fdv\u00e1 neurologick\u00fdmi poruchami souvisej\u00edc\u00edmi s vrozenou expozic\u00ed viru zika (ZIKV).<\/p>\n

Jedn\u00edm z nejv\u00fdrazn\u011bj\u0161\u00edch n\u00e1sledk\u016f, kter\u00e9 byly u novorozenc\u016f naka\u017een\u00fdch virem ZIKV zaznamen\u00e1ny, je vrozen\u00e1 mikrocefalie. Z tohoto d\u016fvodu se v\u00fdzkumn\u00e9 \u00fasil\u00ed zam\u011b\u0159uje na pochopen\u00ed mechanism\u016f vrozen\u00e9 mikrocefalie zp\u016fsoben\u00e9 virem ZIKV.<\/p>\n

Pouze u 1 a\u017e 13% exponovan\u00fdch plod\u016f se v\u0161ak po narozen\u00ed projev\u00ed t\u011blesn\u00e9 malformace. Krom\u011b toho chyb\u00ed informace o dlouhodob\u00fdch n\u00e1sledc\u00edch perinat\u00e1ln\u00ed infekce.<\/p>\n

Isis de Souza a jej\u00ed kolegov\u00e9 proto pou\u017eili my\u0161i ke studiu behavior\u00e1ln\u00edch a neuropatologick\u00fdch podm\u00ednek a kr\u00e1tkodob\u00fdch a dlouhodob\u00fdch d\u016fsledk\u016f a v\u00fdsledky publikovali v \u010dl\u00e1nku s n\u00e1zvem Akutn\u00ed a chronick\u00e9 neurologick\u00e9 n\u00e1sledky infekce virem Zika v ran\u00e9m v\u011bku u my\u0161\u00ed.<\/strong><\/p>\n

U lid\u00ed existuje mnoho klinick\u00fdch stav\u016f spojen\u00fdch s expozic\u00ed viru zika, kter\u00e9 se objevuj\u00ed m\u011bs\u00edce nebo roky po narozen\u00ed. Tak\u017ee i kdy\u017e se d\u011bti nenarod\u00ed s mikrocefali\u00ed, mohou se u nich projevit motorick\u00e9 poruchy, kortik\u00e1ln\u00ed dysplazie souvisej\u00edc\u00ed se z\u00e1chvaty a dal\u0161\u00ed neurologick\u00e9 poruchy.<\/p>\n

Podle autor\u016f \"syst\u00e9mov\u011b infikovali novorozen\u00e9 my\u0161i divok\u00e9ho typu virem ZIKV a provedli dlouhodob\u00e9 sledov\u00e1n\u00ed behavior\u00e1ln\u00edch, neuropatologick\u00fdch a molekul\u00e1rn\u00edch d\u016fsledk\u016f infekce. Uv\u00e1d\u00edme kr\u00e1tkodob\u00e9 a dlouhodob\u00e9 komplikace po infekci ZIKV u my\u0161\u00ed a ukazujeme, \u017ee \u010dasn\u00e1 neutralizace tumor nekrotizuj\u00edc\u00edho faktoru-\u03b1 (TNF-\u03b1) \u010d\u00e1ste\u010dn\u011b zabra\u0148uje t\u011bmto \u0161kodliv\u00fdm \u00fa\u010dink\u016fm. Na\u0161e zji\u0161t\u011bn\u00ed odhaluj\u00ed pot\u0159ebu v\u011bnovat zvl\u00e1\u0161tn\u00ed pozornost potenci\u00e1ln\u00ed z\u00e1t\u011b\u017ei neuropatologick\u00fdch komplikac\u00ed u d\u011bt\u00ed a dosp\u00edvaj\u00edc\u00edch po vrozen\u00e9 expozici ZIKV a nazna\u010duj\u00ed, \u017ee \u010dasn\u00e1 inhibice neuroz\u00e1n\u011btu m\u016f\u017ee b\u00fdt potenci\u00e1ln\u00ed l\u00e9\u010dbou, kter\u00e1 zabr\u00e1n\u00ed dlouhodob\u00fdm neurologick\u00fdm n\u00e1sledk\u016fm u d\u011bt\u00ed infikovan\u00fdch ZIKV.\"<\/em><\/p>\n

 Ocen\u011bn\u00ed podporovan\u00e9 spole\u010dnost\u00ed GE Healthcare Life Sciences<\/strong><\/h2>\n

Cenu \"Pr\u00eamio Jovem Talento em Ci\u00eancias da Vida\" neboli cenu pro mlad\u00e9 talenty v oblasti v\u011bd o \u017eiv\u00e9 p\u0159\u00edrod\u011b ud\u011bluj\u00ed Brazilsk\u00e1 spole\u010dnost pro biochemii a molekul\u00e1rn\u00ed biologii a spole\u010dnost GE Healthcare Life Sciences. V\u011bdeck\u00fd v\u00fdbor vybral p\u011bt kandid\u00e1t\u016f, kte\u0159\u00ed p\u0159edstav\u00ed svou pr\u00e1ci na v\u00fdro\u010dn\u00edm kongresu, akci, kter\u00e1 spojuje profesory a studenty z cel\u00e9 Latinsk\u00e9 Ameriky.<\/p>\n

V\u00fdbor vybral Isis de Oliveiru, kter\u00e1 p\u0159edstavila svou studii o d\u016fsledc\u00edch expozice viru zika.<\/p>\n

\"v\u011bdeck\u00e1
Isis de Oliveira p\u0159i prezentaci sv\u00fdch v\u00fdsledk\u016f<\/figcaption><\/figure>\n

Napsala p\u0159\u00edsp\u011bvek, ve kter\u00e9m d\u011bkuje sv\u00e9 univerzit\u011b a stipendiu, kter\u00e9 j\u00ed umo\u017enilo studovat. Krom\u011b toho vyj\u00e1d\u0159ila nad\u011bji, \u017ee budouc\u00ed generace bude m\u00edt mo\u017enost usilovat o v\u011bdeckou kari\u00e9ru jako ona.<\/p>\n

Proto chceme Isis pogratulovat k jej\u00ed \u00fa\u017easn\u00e9 pr\u00e1ci! Douf\u00e1m, \u017ee svou prac\u00ed inspiruje dal\u0161\u00ed lidi, aby se stali v\u011bdci.<\/p>\n

A pokud chcete sv\u00e1 data vizualizovat, abyste mohli l\u00e9pe komunikovat ve v\u011bd\u011b, m\u016f\u017eete vyzkou\u0161et Mind the Graph:<\/p>\n

\"pozor<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Je v\u017edy \u00fa\u017easn\u00e9 uk\u00e1zat v\u011bdeckou pr\u00e1ci na\u0161ich u\u017eivatel\u016f. Dnes v\u00e1m tedy p\u0159edstav\u00edm brazilskou v\u011bdkyni Isis de Souza a jej\u00ed pr\u00e1ci s virem zika. Isis a jej\u00ed kolegov\u00e9 studuj\u00ed dopad infekce virem zika v ran\u00e9m v\u011bku u my\u0161\u00ed. Je tak\u00e9 u\u017eivatelkou programu Mind the Graph a v\u00edt\u011bzn\u00e1 prezentace j\u00ed p\u0159inesla [...]<\/p>","protected":false},"author":11,"featured_media":9080,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[40],"tags":[299,282,554,71,775,293,316,315],"yoast_head":"\nZika virus: the award-winning study that sheds light on the future<\/title>\n<meta name=\"description\" content=\"Microcephaly is a known effect related to congenital exposure to zika virus. But there is a lack of information of long-term consequences of the infection.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/cs\/award-zika-virus-fertozes\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zika virus: the award-winning study that sheds light on the future\" \/>\n<meta property=\"og:description\" content=\"Microcephaly is a known effect related to congenital exposure to zika virus. 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