{"id":8527,"date":"2019-03-20T18:17:14","date_gmt":"2019-03-20T21:17:14","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8527"},"modified":"2022-10-19T10:38:06","modified_gmt":"2022-10-19T13:38:06","slug":"nature-neuroscience","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/cs\/priroda-neurologie\/","title":{"rendered":"Nature neuroscience: souvislost mezi schizofreni\u00ed a mikrogli\u00ed"},"content":{"rendered":"<p>Schizofrenie je chronick\u00e1 a z\u00e1va\u017en\u00e1 du\u0161evn\u00ed porucha, kter\u00e1 ovliv\u0148uje my\u0161len\u00ed, c\u00edt\u011bn\u00ed a chov\u00e1n\u00ed \u010dlov\u011bka. Lid\u00e9 trp\u00edc\u00ed schizofreni\u00ed mohou m\u00edt pocit, \u017ee ztratili kontakt s realitou. Abychom pochopili v\u00fdvoj schizofrenie, mus\u00edme hovo\u0159it o synaptick\u00e9m pro\u0159ez\u00e1v\u00e1n\u00ed. Podle \u010dl\u00e1nku z \u010dasopisu Nature neuroscience <sup>1<\/sup>, &#8220;<em>synaptick\u00e9 pro\u0159ez\u00e1v\u00e1n\u00ed je proces eliminace synaps\u00ed, ke kter\u00e9mu doch\u00e1z\u00ed v ran\u00e9m d\u011btstv\u00ed a\u017e do ran\u00e9 dosp\u011blosti.\"<\/em>&nbsp;B\u011bhem v\u00fdvoje mozku se nervov\u00e9 obvody utv\u00e1\u0159ej\u00ed vlivem prost\u0159ed\u00ed. Tento proces eliminuje nadbyte\u010dn\u00e9 synapse vznikl\u00e9 b\u011bhem ran\u00e9ho v\u00fdvoje a posiluje zb\u00fdvaj\u00edc\u00ed synapse.<\/p>\n\n\n\n<p>Podle hypot\u00e9zy \"synaptick\u00e9ho pro\u0159ez\u00e1v\u00e1n\u00ed\" nav\u00edc nadm\u011brn\u00e9 nebo naru\u0161en\u00e9 synaptick\u00e9 pro\u0159ez\u00e1v\u00e1n\u00ed souvis\u00ed s poruchou schizofrenie. Tuto hypot\u00e9zu vyslovil v roce 1982 psychiatr Irwin Feinberg.<\/p>\n\n\n\n<p>P\u0159ed n\u011bkolika lety nav\u00edc p\u0159inesly zobrazovac\u00ed a posmrtn\u00e9 studie lidsk\u00e9ho mozku nov\u00e9 d\u016fkazy na podporu hypot\u00e9zy \"synaptick\u00e9ho pro\u0159ez\u00e1v\u00e1n\u00ed\". Tyto d\u016fkazy uk\u00e1zaly, \u017ee hustota p\u00e1te\u0159e a \u0161ed\u00e1 hmota jsou v k\u016f\u0159e mozkov\u00e9 u pacient\u016f se schizofreni\u00ed sn\u00ed\u017eeny.<a href=\"https:\/\/mindthegraph.com\/templates\" target=\"_blank\" rel=\"noopener\"><br><\/a><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"768\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69596-1-1024x768.png\" alt=\"n\u00e1hled_69596 (1)\" class=\"wp-image-8555\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69596-1-1024x768.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69596-1-300x225.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69596-1-768x576.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n\n<h3>&nbsp;<\/h3>\n\n\n\n<div class=\"is-content-justification-center is-layout-flex wp-container-1 wp-block-buttons\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/mindthegraph.com\/science_figures\">Jste p\u0159ipraveni za\u010d\u00edt pracovat na Mind the Graph?<\/a><\/div>\n<\/div>\n\n\n\n<h3><strong>&nbsp;Nov\u00e9 d\u016fkazy zve\u0159ejn\u011bn\u00e9 v \u010dasopise Nature neuroscience:<\/strong><\/h3>\n\n\n\n<p>V\u011bdci se proto nyn\u00ed sna\u017e\u00ed pochopit mechanismus, kter\u00fd je za t\u00edmto jevem. Podle Carla Sellgrena, Roye Perlise a jejich spolupracovn\u00edk\u016f m\u016f\u017ee v nadm\u011brn\u00e9m pro\u0159ez\u00e1v\u00e1n\u00ed synaps\u00ed hr\u00e1t roli imunitn\u00ed syst\u00e9m. Jejich nov\u00fd \u010dl\u00e1nek<sup>1<\/sup> publikovan\u00fd v \u010dasopise Nature neuroscience popisuje model in vitro, kter\u00fd vyu\u017e\u00edv\u00e1 bun\u011b\u010dn\u00e9 p\u0159eprogramov\u00e1n\u00ed ke studiu pohlcov\u00e1n\u00ed synaps\u00ed zprost\u0159edkovan\u00e9ho mikrogliemi specifick\u00fdmi pro pacienty se schizofreni\u00ed.<\/p>\n\n\n\n<p>Mikroglie jsou skupinov\u00fdm typem neuroglie (gliov\u00e9 bu\u0148ky), kter\u00e9 se nach\u00e1zej\u00ed v mozku a m\u00ed\u0161e. Tvo\u0159\u00ed 10-15% v\u0161ech bun\u011bk, kter\u00e9 se nach\u00e1zej\u00ed v mozku. Jako rezidentn\u00ed makrof\u00e1gov\u00e9 bu\u0148ky p\u016fsob\u00ed jako prvn\u00ed a hlavn\u00ed forma aktivn\u00ed imunitn\u00ed obrany v centr\u00e1ln\u00edm nervov\u00e9m syst\u00e9mu (CNS). Krom\u011b toho jsou mikroglie schopny rozpozn\u00e1vat ciz\u00ed t\u011blesa, pohlcovat je a p\u016fsobit jako antigen prezentuj\u00edc\u00ed bu\u0148ky aktivuj\u00edc\u00ed T-bu\u0148ky.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"768\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69544-1024x768.png\" alt=\"n\u00e1hled_69544\" class=\"wp-image-8529\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69544-1024x768.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69544-300x225.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69544-768x576.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"1024\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69618-1-1024x1024.png\" alt=\"n\u00e1hled_69618\" class=\"wp-image-8531\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-1024x1024.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-150x150.png 150w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-300x300.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-768x768.png 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1.png 1980w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"640\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69620-1024x640.png\" alt=\"n\u00e1hled_69620\" class=\"wp-image-8532\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69620-1024x640.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69620-300x188.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69620-768x480.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n\n<div class=\"is-content-justification-center is-layout-flex wp-container-2 wp-block-buttons\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/mindthegraph.com\/science_figures\">Za\u010dn\u011bte tvo\u0159it na Mind the Graph hned te\u010f<\/a><\/div>\n<\/div>\n\n\n\n<h2>\u010ct\u011bte d\u00e1l o t\u00e9matech z oblasti neurov\u011bd<\/h2>\n\n\n\n<ul><li><a href=\"https:\/\/blog.mindthegraph.com\/alzheimers-disease\/#.XJlCeZhKiUk\" target=\"_blank\" rel=\"noopener\">Alzheimerova choroba: V\u011bdeck\u00e1 infografika<\/a><\/li><li><a href=\"https:\/\/blog.mindthegraph.com\/alzheimers-graphical-abstracts\/#.XJlCiJhKiUk\" target=\"_blank\" rel=\"noopener\">Grafick\u00e9 abstrakty Alzheimerovy choroby: Co je nov\u00e9ho v neurov\u011bd\u00e1ch v n\u00e1zorn\u00e9 podob\u011b<\/a><\/li><\/ul>\n\n\n\n<p>Pokud chcete sv\u016fj v\u00fdzkum prezentovat tak\u00e9 vizu\u00e1ln\u011b, grafick\u00e9 abstrakty a kr\u00e1sn\u00e9 v\u011bdeck\u00e9 ilustrace jsou mocn\u00fdm n\u00e1strojem! Za\u010dn\u011bte tedy je\u0161t\u011b dnes vizualizovat sv\u00e1 data.<\/p>\n\n\n\n<ol><li><a href=\"https:\/\/www.nature.com\/articles\/s41593-018-0334-7\" target=\"_blank\" rel=\"noreferrer noopener\">Zv\u00fd\u0161en\u00e1 eliminace synaps\u00ed mikrogliemi v modelech synaptick\u00e9ho pro\u0159ez\u00e1v\u00e1n\u00ed odvozen\u00fdch od pacient\u016f se schizofreni\u00ed.<\/a><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>Schizofrenie je chronick\u00e1 a z\u00e1va\u017en\u00e1 du\u0161evn\u00ed porucha, kter\u00e1 ovliv\u0148uje my\u0161len\u00ed, c\u00edt\u011bn\u00ed a chov\u00e1n\u00ed \u010dlov\u011bka. Lid\u00e9 trp\u00edc\u00ed schizofreni\u00ed mohou m\u00edt pocit, \u017ee ztratili kontakt s realitou. Abychom pochopili v\u00fdvoj schizofrenie, mus\u00edme hovo\u0159it o synaptick\u00e9m pro\u0159ez\u00e1v\u00e1n\u00ed. Podle \u010dl\u00e1nku z \u010dasopisu Nature neuroscience 1 \"synaptick\u00e9 pro\u0159ez\u00e1v\u00e1n\u00ed je proces, p\u0159i kter\u00e9m doch\u00e1z\u00ed k po\u0161kozen\u00ed synapse, a to [...].<\/p>","protected":false},"author":11,"featured_media":8536,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[96,554,775],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Neuroscience of nature: see the link between schizophrenia and microglia<\/title>\n<meta name=\"description\" content=\"A new paper in Nature neuroscience magazine brings new evidences of the microglial cells role in the schizophrenia development\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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