{"id":7254,"date":"2017-06-21T17:35:04","date_gmt":"2017-06-21T20:35:04","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=7254"},"modified":"2022-10-18T08:29:23","modified_gmt":"2022-10-18T11:29:23","slug":"alzheimers-graphical-abstracts","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/cs\/alzheimers-graphical-abstracts\/","title":{"rendered":"Grafick\u00e9 abstrakty Alzheimerovy choroby: Co je nov\u00e9ho v neurov\u011bd\u00e1ch v n\u00e1zorn\u00e9 podob\u011b"},"content":{"rendered":"

Velmi r\u00e1di se pochlub\u00edme neuv\u011b\u0159itelnou prac\u00ed na\u0161ich u\u017eivatel\u016f - zejm\u00e9na pokud publikuj\u00ed \u010dl\u00e1nky s pou\u017eit\u00edm ilustrac\u00ed a n\u00e1stroj\u016f Mind the Graph.<\/span><\/p>\n

Dnes v\u00e1m tedy uk\u00e1\u017eeme v\u00fdzkum pr\u00e9miov\u00e9ho u\u017eivatele v mysli grafu, Stefania Forner<\/a>. Jej\u00ed p\u0159ehledov\u00fd \u010dl\u00e1nek byl ned\u00e1vno publikov\u00e1n v \u010dasopise Trends in Neurosciences pod n\u00e1zvem<\/span> Po\u0161kozen\u00ed synaptick\u00fdch funkc\u00ed u Alzheimerovy choroby: Dif\u00fazn\u00ed symfonie.<\/a> <\/b>\u00a0Pro ilustraci sv\u00e9 pr\u00e1ce vytvo\u0159ila dva grafick\u00e9 abstrakty Alzheimerovy choroby.<\/p>\n

Nejprve za\u010dn\u011bme mal\u00fdm p\u0159edstaven\u00edm studijn\u00edho oboru Stefania.<\/strong>:<\/span><\/p>\n

Alzheimerova choroba (AD) je neurodegenerativn\u00ed onemocn\u011bn\u00ed, kter\u00e9 zp\u016fsobuje kognitivn\u00ed poruchy a ztr\u00e1tu pam\u011bti. Alzheimerova choroba je \u0161estou nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dinou \u00famrt\u00ed v USA a postihuje 35 milion\u016f lid\u00ed<\/strong> po cel\u00e9m sv\u011bt\u011b. <\/span><\/p>\n

D\u016fkazy nazna\u010duj\u00ed, \u017ee existuje p\u0159\u00ed\u010dinn\u00e1 souvislost mezi kognitivn\u00edm deficitem u AD a \u00fabytkem synaps\u00ed. Tak\u00e9 dysfunkce synaps\u00ed m\u016f\u017ee souviset se dv\u011bma patologick\u00fdmi cestami. Extracelul\u00e1rn\u00ed akumulace peptid beta-amyloid<\/strong> a intracelul\u00e1rn\u00ed akumulace tau protein<\/strong>.<\/span><\/p>\n

Je zn\u00e1mo, \u017ee tyto dva procesy hraj\u00ed u AD d\u016fle\u017eitou roli. Jednou z hlavn\u00edch z\u00e1sadn\u00edch ot\u00e1zek, kter\u00e9 z\u016fst\u00e1vaj\u00ed, je v\u0161ak vztah mezi beta-amyloidem a tau a zp\u016fsob, jak\u00fdm tito dva akt\u00e9\u0159i vz\u00e1jemn\u011b ovliv\u0148uj\u00ed poruchy synaptick\u00fdch funkc\u00ed u AD.<\/span><\/p>\n

Stefania proto pou\u017eila dva grafick\u00e9 abstrakty, kter\u00e9 vytvo\u0159ila na platform\u011b Mind the Graph, aby analyzovala zvl\u00e1\u0161\u0165 vliv tau proteinu a beta-amyloidn\u00edho peptidu na synaptick\u00e9 funkce a AD. Jedn\u00edm z nich uk\u00e1zala tvorbu oligomer\u016f beta-amyloidu a mechanismy jejich synaptick\u00e9 toxicity a druh\u00fdm vztah mezi proteinem tau a synapsemi v neuronech. \u00a0<\/span><\/p>\n

Grafick\u00e9 abstrakty Alzheimerovy choroby<\/strong><\/h2>\n

\"Alzheimerova<\/a><\/p>\n

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\"alzheimerova<\/a><\/p>\n

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\"Studie zkoumaj\u00edc\u00ed molekul\u00e1rn\u00ed vztah mezi A\u00df, tau a synaptick\u00fdm deficitem a\/nebo ztr\u00e1tou synaptick\u00fdch funkc\u00ed objasnily, jak tyto patologie mohou v kone\u010dn\u00e9m d\u016fsledku v\u00e9st k poklesu kognitivn\u00edch funkc\u00ed u pacient\u016f. Identifikace n\u011bkolika potenci\u00e1ln\u00edch pre- a postsynaptick\u00fdch drah m\u016f\u017ee p\u0159isp\u011bt k z\u00e1kladn\u00edm klinick\u00fdm p\u0159\u00edznak\u016fm AD.\"<\/p>\n<\/blockquote>\n

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Chci tak\u00e9 grafick\u00e9 abstrakty ke sv\u00e9mu v\u00fdzkumu!<\/b><\/h2>\n

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Grafick\u00e9 abstrakty jsou zp\u016fsobem, jak doplnit a ilustrovat hlavn\u00ed body va\u0161\u00ed pr\u00e1ce. Pokud se chcete dozv\u011bd\u011bt, jak vytvo\u0159it vlastn\u00ed \u00fa\u017easn\u00e9 grafick\u00e9 abstrakty, zde je n\u011bkolik p\u0159\u00edsp\u011bvk\u016f, kter\u00e9 v\u00e1m pomohou:<\/span><\/p>\n