{"id":26601,"date":"2023-03-02T10:34:57","date_gmt":"2023-03-02T13:34:57","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/understanding-cervical-cancer-copy\/"},"modified":"2023-03-09T17:59:22","modified_gmt":"2023-03-09T20:59:22","slug":"crispr-therapy","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/cs\/crispr-terapie\/","title":{"rendered":"Jak funguje terapie CRISPR v genov\u00e9 terapii?"},"content":{"rendered":"<p>Rakovina je ji\u017e dlouho obt\u00ed\u017en\u00fdm a r\u016fznorod\u00fdm onemocn\u011bn\u00edm, jeho\u017e p\u0159\u00ed\u010dinou jsou zm\u011bny v DNA jedince, kter\u00e9 aktivuj\u00ed onkogeny a z\u00e1rove\u0148 inaktivuj\u00ed n\u00e1dorov\u00e9 supresory, co\u017e zp\u016fsobuje tak\u00e9 dysregulaci epigenomu, kter\u00fd m\u00e1 na starosti koordinaci norm\u00e1ln\u00ed genov\u00e9 exprese.<\/p>\n\n\n\n<p>Stru\u010dn\u011b \u0159e\u010deno, rakovina je bun\u011b\u010dn\u00e9 onemocn\u011bn\u00ed, kter\u00e9 zp\u016fsobuje zm\u011bny v metabolismu a struktu\u0159e bun\u011bk, co\u017e vede k tomu, \u017ee tyto bu\u0148ky jsou po\u0161kozeny do t\u00e9 m\u00edry, \u017ee ji\u017e nefunguj\u00ed spr\u00e1vn\u011b a vyh\u00fdbaj\u00ed se obrann\u00fdm mechanism\u016fm hostitele.&nbsp;<\/p>\n\n\n\n<p>Zkoum\u00e1n\u00ed rakoviny se v\u011bnuje cel\u00e1 \u0159ada odborn\u00edk\u016f a profesion\u00e1l\u016f, kte\u0159\u00ed se sna\u017e\u00ed dokonale pochopit v\u0161echny jej\u00ed slo\u017eitosti a nejasnosti. Pozn\u00e1n\u00ed toho, jak se m\u011bn\u00ed genom, jak se bu\u0148ka p\u0159izp\u016fsobuje a jak doch\u00e1z\u00ed k iniciaci onemocn\u011bn\u00ed, je jedn\u00edm z rozhoduj\u00edc\u00edch faktor\u016f pro v\u00fdvoj \u00fa\u010dinn\u011bj\u0161\u00edch mo\u017enost\u00ed l\u00e9\u010dby a zlep\u0161en\u00ed v\u00fdsledk\u016f pro pacienty s rakovinou.&nbsp;<\/p>\n\n\n\n<p>Terapie CRISPR se prosadila jako technika pro zkoum\u00e1n\u00ed funkce bun\u011bk a v\u00fdznamn\u011b ovlivnila v\u00fdzkum rakoviny, co\u017e vedlo k nov\u00fdm poznatk\u016fm, kter\u00e9 by m\u011bly urychlit diagnostiku a l\u00e9\u010dbu.&nbsp;<\/p>\n\n\n\n<h2>Co je terapie CRISPR?<\/h2>\n\n\n\n<p>Od chv\u00edle, kdy v\u011bdci zjistili, \u017ee zm\u011bny v DNA zp\u016fsobuj\u00ed rakovinu, hledaj\u00ed zp\u016fsob, jak tyto zm\u011bny napravit pomoc\u00ed manipulace s DNA. Jedn\u00edm z nalezen\u00fdch p\u0159\u00edstup\u016f je terapie CRISPR.<\/p>\n\n\n\n<p>L\u00e9\u010dba CRISPR dok\u00e1\u017ee upravovat DNA lidsk\u00fdch bun\u011bk stejn\u011b jako extr\u00e9mn\u011b p\u0159esn\u00e9 a snadno ovladateln\u00e9 n\u016f\u017eky. CRISPR upravuje geny tak, \u017ee pe\u010dliv\u011b st\u0159\u00edh\u00e1 DNA a pot\u00e9 ji systematicky nech\u00e1v\u00e1 opravit.&nbsp;<\/p>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"651\" height=\"174\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2023\/02\/banner-blog-trial-03.jpg\" alt=\"\" class=\"wp-image-26762\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2023\/02\/banner-blog-trial-03.jpg 651w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2023\/02\/banner-blog-trial-03-300x80.jpg 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2023\/02\/banner-blog-trial-03-18x5.jpg 18w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2023\/02\/banner-blog-trial-03-100x27.jpg 100w\" sizes=\"(max-width: 651px) 100vw, 651px\" \/><\/figure><\/div>\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2>Jak terapie CRISPR funguje?<\/h2>\n\n\n\n<p>Technika CRISPR v laborato\u0159i zahrnuje dva kl\u00ed\u010dov\u00e9 prvky: vodic\u00ed RNA a enzym pro \u0159ez\u00e1n\u00ed DNA, nej\u010dast\u011bji Cas9.<\/p>\n\n\n\n<p>Aby bylo mo\u017en\u00e9 genetick\u00e9 n\u016f\u017eky CRISPR pou\u017e\u00edt ke zm\u011bn\u011b genomu, je t\u0159eba nejprve lokalizovat sekvenci DNA, kter\u00e1 m\u00e1 b\u00fdt zm\u011bn\u011bna. Jakmile je p\u0159\u00edslu\u0161n\u00e1 sekvence DNA identifikov\u00e1na, je ur\u010dena jedna vodic\u00ed RNA (sgRNA), kter\u00e1 ji rozpozn\u00e1 a p\u0159ipoj\u00ed se k n\u00ed.&nbsp;<\/p>\n\n\n\n<p>Sekvence vodic\u00ed RNA dopl\u0148uje sekvenci c\u00edlov\u00e9 DNA. To znamen\u00e1, \u017ee vodic\u00ed RNA se v ide\u00e1ln\u00edm p\u0159\u00edpad\u011b p\u0159ipoj\u00ed pouze k c\u00edlov\u00e9 sekvenci DNA a nep\u0159ipoj\u00ed se k jin\u00fdm \u010d\u00e1stem genomu.&nbsp;<\/p>\n\n\n\n<p>Enzym Cas9 (molekul\u00e1rn\u00ed n\u016f\u017ekov\u00fd protein) se p\u0159ipoj\u00ed k RNA a navede n\u016f\u017eky na p\u0159esn\u00e9 m\u00edsto v genomu, kde je t\u0159eba prov\u00e9st st\u0159ih.&nbsp;<\/p>\n\n\n\n<p>Tento opravn\u00fd proces m\u016f\u017ee b\u00fdt \u0159\u00edzen tak, aby upravil DNA v dan\u00e9m m\u00edst\u011b genomu. Nap\u0159\u00edklad gen m\u016f\u017ee b\u00fdt odstran\u011bn nebo aktualizov\u00e1n, aby se opravily v\u0161echny chyby v jeho sekvenci.<\/p>\n\n\n\n<p>V z\u00e1vislosti na tom, jak je syst\u00e9m CRISPR naprogramov\u00e1n, existuj\u00ed t\u0159i mo\u017en\u00e9 v\u00fdsledky po vyst\u0159i\u017een\u00ed c\u00edlov\u00e9 sekvence:&nbsp;<\/p>\n\n\n\n<ol>\n<li>Do DNA se vnese mutace, kter\u00e1 \u0159ez zacel\u00ed.&nbsp;<\/li>\n\n\n\n<li>Enzymy jsou navr\u017eeny tak, aby vytv\u00e1\u0159ely \u0159ezy na obou stran\u00e1ch c\u00edlov\u00e9 DNA, aby se odstranila c\u00edlov\u00e1 DNA a znovu se spojily jej\u00ed konce.&nbsp;<\/li>\n\n\n\n<li>Segment HDR m\u016f\u017ee b\u00fdt do genomu vlo\u017een homologn\u00ed rekombinac\u00ed.<a href=\"https:\/\/www.researchgate.net\/profile\/Konda-Mani-Saravanan\/publication\/355845141\/figure\/fig3\/AS:1128285891235840@1646015727249\/Mechanism-of-action-of-CRISPR-Cas9-techniques-CRIPSPR-Cas9-gene-with-cleavage-activities.png\"><\/a><\/li>\n<\/ol>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"896\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2023\/02\/crispr-cas9-gene-editing-1024x896.jpg\" alt=\"\" class=\"wp-image-27027\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2023\/02\/crispr-cas9-gene-editing-1024x896.jpg 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2023\/02\/crispr-cas9-gene-editing-300x263.jpg 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2023\/02\/crispr-cas9-gene-editing-768x672.jpg 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2023\/02\/crispr-cas9-gene-editing-14x12.jpg 14w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2023\/02\/crispr-cas9-gene-editing-100x88.jpg 100w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2023\/02\/crispr-cas9-gene-editing.jpg 1123w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>Vyrobeno s <a href=\"https:\/\/mindthegraph.com\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Mind the Graph<\/strong><\/a><\/em><\/figcaption><\/figure>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2>Jak\u00e9 jsou obavy z CRISPR?<\/h2>\n\n\n\n<ul>\n<li>Dostat CRISPR do bun\u011bk je n\u00e1ro\u010dn\u00e9. V\u011bdci objevili techniku, jak toho dos\u00e1hnout pomoc\u00ed viru, kter\u00fd byl zmutov\u00e1n tak, aby nesl geny pro vodic\u00ed RNA a Cas9. Vzhledem k tomu, \u017ee n\u011bkter\u00e9 viry mohou infikovat r\u016fzn\u00e9 typy bun\u011bk, mohou nakonec zm\u011bnit nap\u0159\u00edklad svalov\u00e9 bu\u0148ky, a\u010dkoli jejich z\u00e1m\u011brem byly jatern\u00ed bu\u0148ky.<\/li>\n\n\n\n<li>CRISPR se teprve nyn\u00ed testuje na lidech a v\u011bdci se ob\u00e1vaj\u00ed, jak m\u016f\u017ee t\u011blo a imunitn\u00ed syst\u00e9m reagovat na viry, kter\u00e9 obsahuj\u00ed CRISPR, nebo na samotn\u00e9 prvky CRISPR. Proto\u017ee tyto prvky jsou pro \u010dlov\u011bka nezn\u00e1m\u00e9, m\u016f\u017ee imunitn\u00ed syst\u00e9m napadnout a zni\u010dit bu\u0148ky upraven\u00e9 pomoc\u00ed CRISPR.<\/li>\n\n\n\n<li>CRISPR ob\u010das p\u0159eru\u0161\u00ed DNA mimo c\u00edlov\u00fd gen, co\u017e se ozna\u010duje jako \"off-target\" \u0159ez\u00e1n\u00ed. V\u011bdci se ob\u00e1vaj\u00ed, \u017ee takov\u00e9 ne\u00famysln\u00e9 zm\u011bny mohou b\u00fdt p\u0159\u00edli\u0161 \u0161kodliv\u00e9 a dokonce rakovinotvorn\u00e9.<\/li>\n\n\n\n<li>Dal\u0161\u00edm d\u016fle\u017eit\u00fdm probl\u00e9mem je, \u017ee modifikace bun\u011bk v t\u011ble m\u016f\u017ee ne\u00famysln\u011b zm\u011bnit spermie nebo vaje\u010dn\u00e9 bu\u0148ky, kter\u00e9 mohou b\u00fdt p\u0159ed\u00e1ny budouc\u00edm generac\u00edm.<\/li>\n<\/ul>\n\n\n\n<h3>Etick\u00e9 ot\u00e1zky<\/h3>\n\n\n\n<p>L\u00e9\u010dba CRISPR vyvol\u00e1v\u00e1 i etick\u00e9 obavy. N\u00ed\u017ee jsou uvedeny n\u011bkter\u00e9 etick\u00e9 probl\u00e9my:<\/p>\n\n\n\n<ul>\n<li>Jak ji\u017e bylo \u0159e\u010deno, zm\u011bna bun\u011bk v t\u011ble m\u016f\u017ee omylem ovlivnit spermie nebo vaje\u010dn\u00e9 bu\u0148ky, co\u017e se m\u016f\u017ee p\u0159en\u00e9st na dal\u0161\u00ed generace. Nam\u00edsto l\u00e9\u010den\u00ed nemoc\u00ed mohou b\u00fdt tyto zm\u011bny hypoteticky vyu\u017eity ke zlep\u0161en\u00ed \u017e\u00e1douc\u00edch vlastnost\u00ed.&nbsp;<\/li>\n\n\n\n<li>Mnoho lid\u00ed se z mor\u00e1ln\u00edho a n\u00e1bo\u017eensk\u00e9ho hlediska stav\u00ed proti vyu\u017e\u00edv\u00e1n\u00ed lidsk\u00fdch embry\u00ed ve v\u00fdzkumu. Obecn\u011b lze \u0159\u00edci, \u017ee v\u00fdzkum embry\u00ed m\u016f\u017ee zahrnovat \u017eivotaschopn\u00e1 nebo ne\u017eivotaschopn\u00e1 embrya, kter\u00e1 zbyla po IVF, nebo embrya vytvo\u0159en\u00e1 speci\u00e1ln\u011b pro \u00fa\u010dely studie. Ka\u017ed\u00fd p\u0159\u00edpad m\u00e1 sv\u00e9 specifick\u00e9 etick\u00e9 probl\u00e9my.<\/li>\n\n\n\n<li>Existuj\u00ed obavy, \u017ee editace genomu bude omezena na bohat\u00e9, co\u017e prohloub\u00ed st\u00e1vaj\u00edc\u00ed rozd\u00edly v p\u0159\u00edstupu ke zdravotn\u00ed p\u00e9\u010di i k jin\u00fdm l\u00e9\u010debn\u00fdm postup\u016fm.<\/li>\n<\/ul>\n\n\n\n<h2>Neztr\u00e1cejte \u010das! Snadno pou\u017eiteln\u00e1 platforma, kterou m\u016f\u017ee pou\u017e\u00edvat t\u00e9m\u011b\u0159 ka\u017ed\u00fd.<\/h2>\n\n\n\n<p>Pomoc\u00ed snadno pou\u017eiteln\u00e9ho n\u00e1stroje m\u016f\u017eete vytv\u00e1\u0159et \u00fa\u017easn\u00e9 infografiky, ilustrace nebo dokonce p\u0159em\u011bnit svou pr\u00e1ci na n\u00e1dhern\u00fd a srozumiteln\u00fd plak\u00e1t. <a href=\"https:\/\/mindthegraph.com\" target=\"_blank\" rel=\"noreferrer noopener\">Pozor na graf<\/a> je pro v\u00e1s vhodn\u00fdm n\u00e1strojem; m\u016f\u017eete pou\u017e\u00edt \u0161ablony nebo si dokonce vy\u017e\u00e1dat takovou, kter\u00e1 bude p\u0159esn\u011b odpov\u00eddat va\u0161im p\u0159edstav\u00e1m!<\/p>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"600\" height=\"338\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/10\/r3qiu0qenda-3.gif\" alt=\"\" class=\"wp-image-25130\"\/><\/figure><\/div>\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"is-layout-flex wp-block-buttons\">\n<div class=\"wp-block-button aligncenter\"><a class=\"wp-block-button__link has-background wp-element-button\" href=\"https:\/\/mindthegraph.com\/\" style=\"border-radius:50px;background-color:#dc1866\" target=\"_blank\" rel=\"noreferrer noopener\">Zvy\u0161te sv\u016fj v\u00fdzkum pomoc\u00ed ilustrac\u00ed<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:44px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Pochopte, co je to CRISPR a jak lze tuto genovou terapii vyu\u017e\u00edt k \u00faprav\u011b DNA a zlep\u0161it tak l\u00e9\u010dbu rakoviny.<\/p>","protected":false},"author":28,"featured_media":26609,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>How Does CRISPR Therapy Operate in Gene Therapy?<\/title>\n<meta name=\"description\" content=\"Understand what CRISPR is and how this gene therapy can be used to modify DNA, enhancing the treatment of cancer.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/cs\/crispr-terapie\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How Does CRISPR Therapy Operate in Gene Therapy?\" \/>\n<meta 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