{"id":16670,"date":"2022-09-16T19:40:00","date_gmt":"2022-09-16T22:40:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16670"},"modified":"2023-03-17T14:47:16","modified_gmt":"2023-03-17T17:47:16","slug":"success-case-nuclear-receptors-in-liver-fibrosis","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/cs\/success-case-nuclear-receptors-in-liver-fibrosis\/","title":{"rendered":"Nukle\u00e1rn\u00ed receptory ve fibr\u00f3ze jater Paper Review"},"content":{"rendered":"

V tomto p\u0159\u00edpad\u011b autor pou\u017eil Mind the Graph ke shrom\u00e1\u017ed\u011bn\u00ed \u00fadaj\u016f z r\u016fzn\u00fdch zdroj\u016f na jednom m\u00edst\u011b. Krom\u011b nejlep\u0161\u00edch v\u011bdecky p\u0159esn\u00fdch ilustrac\u00ed m\u00e1 n\u00e1\u0161 pracovn\u00ed prostor p\u0159\u00edv\u011btiv\u00e9 rozhran\u00ed a velmi snadno se pou\u017e\u00edv\u00e1.<\/p>\n\n\n\n

Pod\u00edvejte se na kompletn\u00ed p\u016fvodn\u00ed \u010dl\u00e1nek<\/a>. <\/p>\n\n\n\n

\u00daloha jadern\u00fdch receptor\u016f ve fibr\u00f3ze jater<\/strong><\/h2>\n\n\n\n

Philipp K\u00f6nigshofer a spol. (2021) uv\u00e1d\u011bj\u00ed, \u017ee jadern\u00e9 receptory jsou ligandem aktivovan\u00e9 transkrip\u010dn\u00ed faktory, kter\u00e9 reguluj\u00ed genovou expresi \u0159ady kl\u00ed\u010dov\u00fdch molekul\u00e1rn\u00edch sign\u00e1l\u016f pod\u00edlej\u00edc\u00edch se na jatern\u00ed fibr\u00f3ze. <\/p>\n\n\n\n

Prim\u00e1rn\u00edm bun\u011b\u010dn\u00fdm motorem jatern\u00ed fibrogeneze jsou aktivovan\u00e9 jatern\u00ed hv\u011bzdicovit\u00e9 bu\u0148ky. R\u016fzn\u00e9 jadern\u00e9 receptory reguluj\u00ed jatern\u00ed expresi proz\u00e1n\u011btliv\u00fdch a profibrogenn\u00edch cytokin\u016f.<\/p>\n\n\n\n

Grafick\u00e9 abstrakty zalo\u017een\u00e9 na Mind the Graph<\/strong> v tomto \u010dl\u00e1nku<\/strong><\/h2>\n\n\n\n
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Vyrobeno s Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n
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Na prvn\u00edm obr\u00e1zku je p\u0159ehled a klasifikace jadern\u00fdch receptor\u016f podle podrodin.<\/p>\n\n\n\n

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Vyrobeno s Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

V\u00fd\u0161e vid\u00edme r\u016fzn\u00e9 typy efektorov\u00fdch funkc\u00ed jadern\u00fdch receptor\u016f.<\/p>\n\n\n\n

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Vyrobeno s Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Na t\u0159et\u00edm obr\u00e1zku je uveden p\u0159ehled uv\u00e1d\u011bn\u00fdch \u00fa\u010dink\u016f modulac\u00ed NR jako potenci\u00e1ln\u00edch terapeutick\u00fdch p\u0159\u00edstup\u016f proti jatern\u00edm onemocn\u011bn\u00edm. <\/p>\n\n\n\n

\u0160ipky ozna\u010duj\u00ed p\u0159edpokl\u00e1dan\u00e9 p\u0159\u00edzniv\u00e9 \u00fa\u010dinky p\u0159i onemocn\u011bn\u00ed jater pomoc\u00ed up- (tmav\u011b zelen\u00e1)<\/strong><\/span> nebo dol\u016f (sv\u011btle zelen\u00e1)<\/span><\/strong> regulace specifick\u00fdch mechanism\u016f, kter\u00e9 \u00fadajn\u011b podporuj\u00ed regresi jatern\u00ed fibr\u00f3zy nebo ji sni\u017euj\u00ed. <\/p>\n\n\n\n

Oran\u017eov\u00e9 \u0161ipky<\/mark><\/strong> nazna\u010duj\u00ed \u00fa\u010dinky a mechanismy modulace NR, kter\u00e9 jsou bu\u010f sporn\u00e9, nebo dosud nedostate\u010dn\u011b vyhodnocen\u00e9.<\/p>\n\n\n\n

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Vyrobeno s Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Posledn\u00ed obr\u00e1zek p\u0159edstavuje molekul\u00e1rn\u00ed \u00fa\u010dinky modul\u00e1tor\u016f NR jako potenci\u00e1ln\u00ed l\u00e9\u010dby jatern\u00ed fibr\u00f3zy, kter\u00e9 se podle zpr\u00e1v vyskytuj\u00ed p\u0159ev\u00e1\u017en\u011b v HSC.<\/p>\n\n\n\n

K\u00f6nigshofer a jeho kolegov\u00e9 navrhuj\u00ed, \u017ee dal\u0161\u00ed v\u00fdzkum signalizace souvisej\u00edc\u00ed s jadern\u00fdmi receptory m\u016f\u017ee v\u00e9st ke klinick\u00e9mu v\u00fdvoji \u00fa\u010dinn\u00fdch antifibrotick\u00fdch terapi\u00ed pro pacienty s onemocn\u011bn\u00edm jater.<\/p>\n\n\n\n

Dokumenty Dopad a v\u00fdkon<\/strong><\/h2>\n\n\n\n

Pokud zvol\u00edme jednoletou variantu porovn\u00e1n\u00ed metrik s ostatn\u00edmi \u010dl\u00e1nky\/recenzemi, kter\u00e9 byly ve stejn\u00e9m kalend\u00e1\u0159n\u00edm roce v dan\u00e9m \u010dasopise rovn\u011b\u017e publikov\u00e1ny, m\u016f\u017eeme si v\u0161imnout, \u017ee tento \u010dl\u00e1nek byl citov\u00e1n v\u00edce ne\u017e 57% z nich<\/strong>.<\/p>\n\n\n

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Zdroj: PlumX<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Vyu\u017eijte s\u00edlu infografiky tak\u00e9 k pos\u00edlen\u00ed sv\u00e9ho \u010dl\u00e1nku. Vyzkou\u0161ejte Mind the Graph!<\/p>\n\n\n\n

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Vyzkou\u0161ejte Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Tento \u010dl\u00e1nek obsahuje v\u011bdeck\u00e9 ilustrace vytvo\u0159en\u00e9 pomoc\u00ed Mind the Graph, kter\u00e9 zn\u00e1zor\u0148uj\u00ed jadern\u00e9 receptory v jatern\u00ed fibr\u00f3ze.<\/p>","protected":false},"author":29,"featured_media":20044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nNuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/cs\/success-case-nuclear-receptors-in-liver-fibrosis\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuclear receptors in liver fibrosis Paper Review - 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