{"id":16657,"date":"2022-09-14T13:04:15","date_gmt":"2022-09-14T16:04:15","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16657"},"modified":"2023-03-17T14:47:26","modified_gmt":"2023-03-17T17:47:26","slug":"success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/cs\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/","title":{"rendered":"XTALKDB: datab\u00e1ze k\u0159\u00ed\u017een\u00ed sign\u00e1ln\u00edch drah Paper Review"},"content":{"rendered":"

Tento \u00fa\u017easn\u00fd \u010dl\u00e1nek p\u0159in\u00e1\u0161\u00ed statistiky shrnuj\u00edc\u00ed data v XTALKDB. Autor b\u011bhem n\u011bkolika minut vytvo\u0159il infografiku vysv\u011btluj\u00edc\u00ed rozlo\u017een\u00ed druh\u016f v XTALKDB.<\/p>\n\n\n\n

Zkontrolujte p\u016fvodn\u00ed \u010dl\u00e1nek zde<\/a>.<\/p>\n\n\n\n

Proto\u017ee lid\u00e9 jsou vizu\u00e1ln\u00ed bytosti, jsou obr\u00e1zky st\u00e1le nejlep\u0161\u00edm zp\u016fsobem, jak vysv\u011btlit sv\u016fj v\u00fdzkum s tolika detaily, kolik chcete.<\/p>\n\n\n\n

V\u011bdci vytvo\u0159ili datab\u00e1zi, kter\u00e1 dokumentuje vz\u00e1jemn\u00e9 ovliv\u0148ov\u00e1n\u00ed konkr\u00e9tn\u00edch dvojic sign\u00e1ln\u00edch drah a druh\u016f a tk\u00e1n\u00ed, v nich\u017e jsou pozorov\u00e1ny.<\/strong><\/h2>\n\n\n\n

V\u00fdzkumn\u00e1 skupina pod veden\u00edm Sarah Samov\u00e9 z katedry biologick\u00fdch v\u011bd (2016) uvedla, \u017ee vn\u00edm\u00e1n\u00ed vn\u011bj\u0161\u00edho sign\u00e1lu receptory zp\u016fsobuje zm\u011bnu aktivity mezilehl\u00fdch protein\u016f. <\/p>\n\n\n\n

To vede k regulaci transkrip\u010dn\u00edch faktor\u016f, kter\u00e9 moduluj\u00ed expresi c\u00edlov\u00fdch gen\u016f. Pro ka\u017edou dvojici drah jsou v datab\u00e1zi XTalkDB zaznamen\u00e1ny podrobn\u00e9 informace popisuj\u00edc\u00ed experiment\u00e1ln\u00ed podm\u00ednky, za kter\u00fdch byla vz\u00e1jemn\u00e1 interakce objevena. <\/p>\n\n\n\n

Bu\u0148ky vyhodnocuj\u00ed sv\u00e9 prost\u0159ed\u00ed a reaguj\u00ed na n\u011bj prost\u0159ednictv\u00edm sign\u00e1ln\u00edch drah. Sign\u00e1ln\u00ed dr\u00e1ha obvykle obsahuje p\u0159esn\u011b definovan\u00fd soubor regula\u010dn\u00edch a fyzik\u00e1ln\u00edch interakc\u00ed mezi receptory, zprost\u0159edkuj\u00edc\u00edmi sign\u00e1ln\u00edmi proteiny, transkrip\u010dn\u00edmi faktory a c\u00edlov\u00fdmi geny. <\/p>\n\n\n\n

Webov\u00e9 str\u00e1nky XTalkDB poskytuj\u00ed v\u011bdc\u016fm snadno pou\u017eiteln\u00e9 rozhran\u00ed pro prohl\u00ed\u017een\u00ed informac\u00ed o k\u0159\u00ed\u017eov\u00fdch vazb\u00e1ch pomoc\u00ed dotazu na jednu nebo v\u00edce drah nebo molekul, kter\u00e9 je zaj\u00edmaj\u00ed.<\/p>\n\n\n\n

Do studie bylo zahrnuto 650 p\u00e1r\u016f.<\/strong><\/p>\n\n\n\n

Grafick\u00e9 abstraktum poh\u00e1n\u011bn\u00e9 Mind the Graph<\/strong><\/h2>\n\n\n
\n
\"success-case-XTALKDB-a-database-of-signaling-pathway-crosstalk\"<\/a>
Vyrobeno s Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

V diskusi o mo\u017en\u00fdch vylep\u0161en\u00edch uvedl: \"Ru\u010dn\u00ed kur\u00e1torsk\u00fd proces, kter\u00fd je z\u00e1kladem XTalkDB, m\u00e1 sv\u00e1 omezen\u00ed, zejm\u00e9na kdy\u017e se sna\u017e\u00edme roz\u0161\u00ed\u0159it pokryt\u00ed datab\u00e1ze. <\/p>\n\n\n\n

Pl\u00e1nujeme vyvinout r\u00e1mec pro zpracov\u00e1n\u00ed p\u0159irozen\u00e9ho jazyka, kter\u00fd bude hodnotit publikace na z\u00e1klad\u011b pravd\u011bpodobnosti, \u017ee budou dokumentovat k\u0159\u00ed\u017eovou stopu. Kur\u00e1tor se pak m\u016f\u017ee zam\u011b\u0159it na vysoce hodnocen\u00e9 publikace,\" p\u0159izn\u00e1vaj\u00ed.<\/p>\n\n\n\n

Dokumenty Dopad a v\u00fdkon<\/strong><\/h2>\n\n\n\n

M\u016f\u017eeme analyzovat pomoc\u00ed Altmetric<\/a> \u00fadaje, \u017ee tento dokument je na horn\u00ed \u010d\u00e1st v\u0161ech metrik v r\u00e1mci v\u0161ech \u010dl\u00e1nk\u016f financovan\u00fdch NIH v dimenz\u00edch. <\/strong><\/p>\n\n\n

\n
\"\"<\/a>
Zdroj: https:\/\/badge.dimensions.ai\/details\/id\/pub.1052462103<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Vyu\u017eijte s\u00edlu infografiky tak\u00e9 k pos\u00edlen\u00ed sv\u00e9ho \u010dl\u00e1nku. Vyzkou\u0161ejte Mind the Graph!<\/p>\n\n\n\n

<\/div>\n\n\n\n
\n
Vyzkou\u0161ejte Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

U\u010dte se s t\u011bmi, kte\u0159\u00ed ji\u017e objevili s\u00edlu infografiky. Tento \u010dl\u00e1nek obsahuje grafick\u00e9 abstrakty vytvo\u0159en\u00e9 pomoc\u00ed Mind the Graph. <\/p>","protected":false},"author":29,"featured_media":20046,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,963],"yoast_head":"\nXTALKDB: a database of signaling pathway crosstalk Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This amazing article brings out statistics summarizing data in XTALKDB with an infographic explaining the distribution of the species in XTALKDB.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/cs\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"XTALKDB: a database of signaling pathway crosstalk Paper Review - 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