{"id":14387,"date":"2021-08-17T17:07:19","date_gmt":"2021-08-17T20:07:19","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=14387"},"modified":"2024-12-05T15:52:16","modified_gmt":"2024-12-05T18:52:16","slug":"what-is-dmt-everything-researchers-know-about-it","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/cs\/co-je-dmt-vsechno-co-o-nem-vyzkumnici-vedi\/","title":{"rendered":"Co je DMT? V\u0161e, co o n\u011bm v\u011bdci v\u011bd\u00ed"},"content":{"rendered":"

Co je DMT?<\/h2>\n\n\n\n

DMT neboli N, N-dimethyltryptamin je p\u0159\u00edrodn\u00ed l\u00e1tka obsa\u017een\u00e1 v listech amazonsk\u00e9 rostliny jm\u00e9nem N, N-dimethyltryptamin. Psychotria Viridis<\/em>, kter\u00fd se pou\u017e\u00edv\u00e1 v n\u00e1poji ayahuasca, kter\u00fd u t\u011bch, kte\u0159\u00ed ho za\u017eij\u00ed, vyvol\u00e1v\u00e1 halucinace a zm\u011bny ve vn\u00edm\u00e1n\u00ed, emoc\u00edch a pozn\u00e1v\u00e1n\u00ed.<\/p>\n\n\n\n

DMT je klasifikov\u00e1n jako psychoaktivn\u00ed alkaloidn\u00ed l\u00e1tka a v roce 1971 byl celosv\u011btov\u011b zak\u00e1z\u00e1n Mezin\u00e1rodn\u00ed \u00famluvou o psychotropn\u00edch l\u00e1tk\u00e1ch, jeho konzumace je povolena pouze v n\u00e1bo\u017eensk\u00fdch a ritu\u00e1ln\u00edch praktik\u00e1ch v r\u00e1mci n\u00e1poje zvan\u00e9ho ayahuasca.<\/p>\n\n\n\n

\"V\u00fdzkum<\/a>
V\u00fdzkum v galerii Mind the Graph pro \"molekuly\".<\/figcaption><\/figure>\n\n\n\n

A\u010dkoli je ayahuasca zn\u00e1m\u00e1 ji\u017e v\u00edce ne\u017e sto let, teprve v posledn\u00edch n\u011bkolika letech p\u0159itahuje pozornost v\u011bdc\u016f d\u00edky sv\u00fdm (zat\u00edm) neprok\u00e1zan\u00fdm \u00fa\u010dink\u016fm.<\/p>\n\n\n\n

N\u00e1poj byl prezentov\u00e1n pro zlep\u0161en\u00ed kvality \u017eivota a l\u00e9\u010dbu pacient\u016f s neurologick\u00fdmi a emo\u010dn\u00edmi poruchami, jako jsou deprese, \u00fazkost a z\u00e1vislost. <\/p>\n\n\n\n

\"Co<\/a><\/figure>\n\n\n\n

Co v\u011bdci v\u011bd\u00ed o DMT<\/h2>\n\n\n\n

\u010cl\u00e1nek zve\u0159ejn\u011bn\u00fd Journal of Affective Disorders Reports<\/a> analyzoval \u00fadaje z pr\u016fzkumu Global Ayahuasca Project (GAP), kter\u00e9ho se z\u00fa\u010dastnilo 11 912 lid\u00ed, kte\u0159\u00ed tento n\u00e1poj vyzkou\u0161eli. V pr\u016fzkumu \u00fa\u010dastn\u00edci, kte\u0159\u00ed p\u0159ed konzumac\u00ed ayahuasky uv\u00e1d\u011bli, \u017ee trp\u011bli depresemi nebo \u00fazkostmi, uvedli, \u017ee po z\u00e1\u017eitku zaznamenali ur\u010ditou m\u00edru zlep\u0161en\u00ed sv\u00fdch p\u0159\u00edznak\u016f. Tedy zlep\u0161en\u00ed kvality jejich \u017eivota. <\/p>\n\n\n\n

Zpr\u00e1vy pacient\u016f, jako je tato, shrom\u00e1\u017ed\u011bn\u00e9 organizac\u00ed GAP, v posledn\u00edch letech p\u0159ib\u00fdvaj\u00ed. P\u0159esto\u017ee jde o dobrou zpr\u00e1vu, v\u011bdci a l\u00e9ka\u0159i pot\u0159ebuj\u00ed \u00fapln\u011bj\u0161\u00ed a podrobn\u011bj\u0161\u00ed fyziologick\u00e9 studie, aby pochopili zdroj t\u011bchto \u00fa\u010dink\u016f ayahuasky. N\u00e1poj-rostlina m\u00e1 v sob\u011b n\u011bkolik l\u00e1tek a ka\u017ed\u00e1 z nich m\u016f\u017ee v lidsk\u00e9m t\u011ble vyvolat jin\u00fd typ reakce. <\/p>\n\n\n\n

Jednou z t\u011bchto l\u00e1tek je DMT. Tato l\u00e1tka z ayahuasky p\u0159itahuje pozornost v\u011bdc\u016f d\u00edky sv\u00e9mu zjevn\u00e9mu neurogenetick\u00e9mu potenci\u00e1lu.   <\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

Co je neurogeneze?<\/h3>\n\n\n\n

Neurogenesis<\/strong> je definov\u00e1n jako proces transformace nervov\u00e9 kmenov\u00e9 bu\u0148ky<\/strong> nebo progenitor<\/strong> bun\u011bk do nov\u00fdch neuron\u016f. Zahrnuje tak\u00e9 mnoho r\u016fzn\u00fdch bun\u011b\u010dn\u00fdch aktivit, v\u010detn\u011b proliferace, migrace a diferenciace bun\u011bk.<\/p>\n\n\n\n

Na opl\u00e1tku, nervov\u00e9 kmenov\u00e9 bu\u0148ky<\/strong> jsou schopny rozs\u00e1hl\u00e9 sebeobnovy a vytv\u00e1\u0159ej\u00ed nov\u00e9 bu\u0148ky nervov\u00e9ho syst\u00e9mu, nap\u0159\u00edklad neurony nebo gliov\u00e9 bu\u0148ky. V na\u0161em mozku existuje nika nervov\u00fdch kmenov\u00fdch bun\u011bk, kter\u00e1 se nach\u00e1z\u00ed v mozkov\u00e9 k\u016f\u0159e. subgranul\u00e1rn\u00ed z\u00f3na<\/strong> dent\u00e1tov\u00e9ho gyru v hipokampu. <\/p>\n\n\n\n

Hipokampus je \u010d\u00e1st mozku, kter\u00e1 je zodpov\u011bdn\u00e1 za na\u0161i pam\u011b\u0165 a schopnost u\u010den\u00ed. Tato oblast mozku je sou\u010d\u00e1st\u00ed limbick\u00e9ho syst\u00e9mu a hraje d\u016fle\u017eitou roli p\u0159i p\u0159em\u011bn\u011b kr\u00e1tkodob\u00e9 pam\u011bti na dlouhodobou. <\/p>\n\n\n\n

U neurodegenerativn\u00edch onemocn\u011bn\u00ed, jako je Alzheimerova choroba, je hipokampus prvn\u00ed oblast\u00ed, kter\u00e1 trp\u00ed a vede k \u00fabytku pam\u011bti. <\/p>\n\n\n\n

Jak DMT p\u016fsob\u00ed na mozek?<\/h3>\n\n\n\n

N\u011bjakou dobu se m\u011blo za to, \u017ee DMT se v\u00e1\u017ee pouze na serotoninov\u00e9 receptory 5-HT, kter\u00e9 vyvol\u00e1vaj\u00ed jeho halucina\u010dn\u00ed \u00fa\u010dinky. Ned\u00e1vn\u00e9 studie v\u0161ak uv\u00e1d\u011bj\u00ed, \u017ee DMT se v\u00e1\u017ee i na jin\u00fd typ receptor\u016f, neserotoninergn\u00ed receptor pojmenovan\u00fd receptor sigma-1<\/strong> nebo S1R<\/strong>. <\/p>\n\n\n\n

Tento receptor je roz\u0161\u00ed\u0159en v centr\u00e1ln\u00ed nervov\u00e9 soustav\u011b, zejm\u00e9na v prefront\u00e1ln\u00ed k\u016f\u0159e a hipokampu. <\/p>\n\n\n\n

V\u011bdci d\u00e1le zjistili, \u017ee p\u0159i vazb\u011b na tento receptor S1R DMT ztr\u00e1c\u00ed sv\u00e9 psychoaktivn\u00ed \u00fa\u010dinky a nevyvol\u00e1v\u00e1 halucinace ani zm\u011bny ve vn\u00edm\u00e1n\u00ed. <\/p>\n\n\n\n

V\u00fdzkum in vitro a in vivo<\/h3>\n\n\n\n

Studie publikovan\u00e1 v \u010dasopise \u010casopis Translational Psychiatry<\/a> v roce 2020 se zam\u011b\u0159il na studium \u00fa\u010dink\u016f DMT v mozku prost\u0159ednictv\u00edm receptoru sigma-1. <\/p>\n\n\n\n

Pomoc\u00ed antagonist\u016f 5-HT v\u011bdci zjistili, \u017ee DMT stimuluje neurogenezi prost\u0159ednictv\u00edm S1R. <\/p>\n\n\n\n

Krom\u011b toho \u00fadaje uk\u00e1zaly, \u017ee DMT p\u016fsob\u00ed nejen jako stimulant, kter\u00fd indukuje zr\u00e1n\u00ed, proliferaci a migraci nervov\u00fdch kmenov\u00fdch bun\u011bk in vitro, ale tak\u00e9 zvy\u0161uje schopnost u\u010den\u00ed a pam\u011bti in vivo. <\/p>\n\n\n\n

Auto\u0159i studie uvedli, \u017ee DMT in vitro podporuje proliferaci neuron\u00e1ln\u00edch progenitorov\u00fdch bun\u011bk z neurogenn\u00ed niky hipokampu dosp\u011bl\u00fdch. Toto p\u016fsoben\u00ed zv\u00fd\u0161ilo po\u010det a velikost neurospheres<\/strong> po t\u00fddnu l\u00e9\u010dby DMT. <\/p>\n\n\n\n

Na z\u00e1klad\u011b exprese specifick\u00fdch protein\u016f v\u011bdci tak\u00e9 zjistili, \u017ee DMT podporuje diferenciaci t\u011bchto nervov\u00fdch kmenov\u00fdch bun\u011bk. <\/p>\n\n\n\n

Proteiny, kter\u00e9 se vyskytuj\u00ed v\u00fdhradn\u011b v mlad\u00fdch a zral\u00fdch neuronech, zvan\u00e9 \u03b2-III-tubulin a MAP-2, m\u011bly zv\u00fd\u0161enou expresi v neurosf\u00e9r\u00e1ch o\u0161et\u0159en\u00fdch DMT. To znamen\u00e1, \u017ee DMT podporuje diferenciaci do neuron\u00e1ln\u00edho fenotypu. <\/p>\n\n\n\n

V\u011bdci tak\u00e9 zaznamenali podporu dal\u0161\u00edch bun\u011b\u010dn\u00fdch fenotyp\u016f, jako jsou astrocyty a oligodendrocyty, a to v\u0161e prost\u0159ednictv\u00edm S1R.<\/p>\n\n\n\n

In vivo se zd\u00e1lo, \u017ee DMT aktivuje niku subgranul\u00e1rn\u00ed z\u00f3ny prost\u0159ednictv\u00edm S1R. <\/p>\n\n\n\n

Dosp\u011bl\u00e9 my\u0161i l\u00e9\u010den\u00e9 DMT m\u011bly podle \u010dl\u00e1nku \"zv\u00fd\u0161enou proliferaci a migraci nervov\u00fdch prekurzor\u016f v subgranul\u00e1rn\u00ed z\u00f3n\u011b\". Tento v\u00fdsledek nazna\u010duje, \u017ee DMT m\u00e1 modeluj\u00edc\u00ed \u00fa\u010dinek na neurogenezi hipokampu a zvy\u0161uje po\u010det nov\u00fdch neuron\u016f. <\/p>\n\n\n\n

Dosp\u011bl\u00e9 my\u0161i l\u00e9\u010den\u00e9 DMT vykazovaly v praxi lep\u0161\u00ed v\u00fdsledky v behavior\u00e1ln\u00edch \u00faloh\u00e1ch ne\u017e my\u0161i, kter\u00e9 DMT nedost\u00e1valy. L\u00e9\u010den\u00e1 skupina vykazovala v\u00fdsledky zlep\u0161en\u00ed v \u00faloh\u00e1ch u\u010den\u00ed a pam\u011bti. <\/p>\n\n\n\n

\"Infografika<\/a><\/figure>\n\n\n\n

Z\u00e1v\u011br<\/h2>\n\n\n\n

V\u0161echny tyto v\u00fdsledky jsou pro l\u00e9ka\u0159skou komunitu skv\u011blou zpr\u00e1vou. <\/p>\n\n\n\n

To ukazuje, \u017ee je mo\u017en\u00e9 nejen stimulovat neurogenezi pomoc\u00ed DMT, ale tak\u00e9 dos\u00e1hnout t\u011bchto v\u00fdsledk\u016f bez halucinogenn\u00edch \u00fa\u010dink\u016f prost\u0159ednictv\u00edm specifick\u00e9ho receptoru. <\/p>\n\n\n\n

\"Tato schopnost modulovat plasticitu mozku nazna\u010duje, \u017ee m\u00e1 velk\u00fd terapeutick\u00fd potenci\u00e1l pro \u0161irokou \u0161k\u00e1lu psychiatrick\u00fdch a neurologick\u00fdch poruch, v\u010detn\u011b neurodegenerativn\u00edch onemocn\u011bn\u00ed,\" uvedl Jos\u00e9 \u00c1ngel Morales ve sv\u00e9m prohl\u00e1\u0161en\u00ed. v\u00fdpis<\/a>, jeden z autor\u016f \u010dl\u00e1nku. <\/p>\n\n\n\n

Tyto v\u00fdsledky mohou v\u00fdrazn\u011b ovlivnit budouc\u00ed studie zahrnuj\u00edc\u00ed ayahuasku a DMT. Pochopen\u00ed toho, jak kontrolovat a ovliv\u0148ovat proces neurogeneze, by mohlo zcela zm\u011bnit zp\u016fsob l\u00e9\u010dby neurodegenerativn\u00edch onemocn\u011bn\u00ed.<\/p>\n\n\n\n

P\u0159esto existuje vysok\u00e1 popt\u00e1vka po studi\u00edch, kter\u00e9 by v\u011bdc\u016fm umo\u017enily pln\u011b pochopit roli l\u00e1tek, jako je DMT, a slibn\u00fdch receptor\u016f, jako je receptor sigma-1, v neurogenezi. <\/p>\n\n\n\n

Spolu s pozitivn\u00ed perspektivou by to mohlo v\u00e9st nejen k nov\u00fdm zp\u016fsob\u016fm l\u00e9\u010dby neurodegenerativn\u00edch onemocn\u011bn\u00ed, ale tak\u00e9 k jejich vyl\u00e9\u010den\u00ed. <\/p>\n\n\n\n

__________________________<\/p>\n\n\n\n

L\u00edbily se v\u00e1m infografiky vytvo\u0159en\u00e9 na z\u00e1klad\u011b v\u00fdsledk\u016f uveden\u00fdch ve v\u011bdeck\u00e9m \u010dl\u00e1nku?<\/p>\n\n\n\n

Tyto infografiky byly vytvo\u0159eny pomoc\u00ed p\u0159ipraven\u00fdch \u0161ablon dostupn\u00fdch v aplikaci Mind the Graph<\/a>, to jeden<\/a> a toto dal\u0161\u00ed<\/a>. Ud\u011blal jsem p\u00e1r zm\u011bn a za chv\u00edli bylo hotovo!<\/p>\n\n\n\n

Tot\u00e9\u017e m\u016f\u017eete ud\u011blat i pro svou v\u00fdzkumnou pr\u00e1ci, nemus\u00edte za\u010d\u00ednat od nuly. Pod\u00edvejte se na v\u0161echny \u0161ablony<\/a> k dispozici v Mind the Graph<\/a>. <\/p>\n\n\n\n

A za\u010dn\u011bte pracovat na sv\u00e9 infografice pr\u00e1v\u011b te\u010f<\/a>! <\/p>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

Co je DMT? DMT neboli N, N-dimethyltryptamin je p\u0159\u00edrodn\u00ed l\u00e1tka obsa\u017een\u00e1 v listech amazonsk\u00e9 rostliny Psychotria Viridis, kter\u00e1 se pou\u017e\u00edv\u00e1 v n\u00e1poji ayahuasca, jen\u017e vyvol\u00e1v\u00e1 halucinace a zm\u011bny ve vn\u00edm\u00e1n\u00ed, emoc\u00edch a pozn\u00e1v\u00e1n\u00ed u t\u011bch, kte\u0159\u00ed ji za\u017eij\u00ed. DMT je klasifikov\u00e1n jako psychoaktivn\u00ed alkaloidn\u00ed l\u00e1tka a byl celosv\u011btov\u011b zak\u00e1z\u00e1n [...]<\/p>","protected":false},"author":18,"featured_media":14389,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[66,959,958,28],"tags":[840,841,51,839,554,250,775,838],"yoast_head":"\nWhat is DMT? Everything Researchers Know About It - MTG<\/title>\n<meta name=\"description\" content=\"Known for its psychoactive activity, the DMT is a substance present in the ayahuasca beverage. 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Everything Researchers Know About It","twitter_image":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/08\/what-is-dmt-twitter.jpg","twitter_misc":{"Written by":"Bruna Soldera","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/what-is-dmt-everything-researchers-know-about-it\/","url":"https:\/\/mindthegraph.com\/blog\/what-is-dmt-everything-researchers-know-about-it\/","name":"What is DMT? Everything Researchers Know About It - MTG","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2021-08-17T20:07:19+00:00","dateModified":"2024-12-05T18:52:16+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/6a3f0be2cd19879e0b9b54457a069602"},"description":"Known for its psychoactive activity, the DMT is a substance present in the ayahuasca beverage. 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