{"id":12274,"date":"2021-02-10T09:13:00","date_gmt":"2021-02-10T11:13:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12274"},"modified":"2023-01-05T13:46:34","modified_gmt":"2023-01-05T16:46:34","slug":"cannabis-and-body-pain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/cs\/konopi-a-bolest-tela\/","title":{"rendered":"Konop\u00ed a bolest t\u011bla"},"content":{"rendered":"

V uplynul\u00e9m desetilet\u00ed p\u0159inesla \u0159ada klinick\u00fdch studi\u00ed pozitivn\u00ed a slibn\u00e9 v\u00fdsledky p\u0159i pou\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f na b\u00e1zi konop\u00ed k l\u00e9\u010db\u011b neuropatick\u00e9 bolesti. <\/p>\n\n\n\n

Konop\u00edm se l\u00e9\u010d\u00ed bolesti spojen\u00e9 s cukrovkou, chemoterapi\u00ed, roztrou\u0161enou skler\u00f3zou, fibromyalgi\u00ed, osteoartritidou a dal\u0161\u00edmi onemocn\u011bn\u00edmi. <\/p>\n\n\n\n

Z\u0159ejm\u011b existuje spojen\u00ed mezi exogenn\u00edmi kanabinoidy a opioidn\u00edmi receptory, co\u017e vede ke zv\u00fd\u0161en\u00ed analgezie pacienta - neschopnosti c\u00edtit bolest. <\/p>\n\n\n\n

U pacient\u016f, kte\u0159\u00ed jsou l\u00e9\u010deni opioidy spole\u010dn\u011b s l\u00e9ky na b\u00e1zi konop\u00ed, se projevuje synergick\u00fd \u00fa\u010dinek l\u00e9ku, kdy se \u00fa\u010dinnost opioid\u016f zvy\u0161uje p\u016fsoben\u00edm tetrahydrokanabinolu - THC, hlavn\u00ed psychoaktivn\u00ed molekuly v rostlin\u011b konop\u00ed. <\/p>\n\n\n\n

V\u011bdci se na tyto v\u00fdsledky d\u00edvaj\u00ed pozitivn\u011b vzhledem k mo\u017enosti sn\u00ed\u017een\u00ed d\u00e1vek opioid\u016f, co\u017e povede ke zlep\u0161en\u00ed kvality \u017eivota pacient\u016f trp\u00edc\u00edch bolest\u00ed.<\/p>\n\n\n\n

Endokanabinoidn\u00ed syst\u00e9m, podobn\u011b jako jin\u00e9 metabolick\u00e9 dr\u00e1hy, nen\u00ed izolovan\u00fdm syst\u00e9mem lidsk\u00e9ho t\u011bla, m\u016f\u017ee b\u00fdt ovliv\u0148ov\u00e1n jin\u00fdmi sign\u00e1ln\u00edmi drahami, z nich\u017e jedna z\u0159ejm\u011b souvis\u00ed s opioidy a jejich receptory. <\/p>\n\n\n\n

Opioidn\u00ed receptory maj\u00ed krom\u011b funkce signalizace pocitu bolesti tak\u00e9 \u00falohu modulovat n\u011bkter\u00e9 t\u011blesn\u00e9 funkce, jako je mimo jin\u00e9 tepeln\u00e1 regulace, hormon\u00e1ln\u00ed stabilita a analgetick\u00e1 aktivita. <\/p>\n\n\n\n

Jak kanabinoidn\u00ed, tak opioidn\u00ed receptory pat\u0159\u00ed do rodiny receptor\u016f sp\u0159a\u017een\u00fdch s G-proteiny, co\u017e jsou proteiny, kter\u00e9 maj\u00ed schopnost ovliv\u0148ovat neurotransmise zodpov\u011bdn\u00e9 za \u0161\u00ed\u0159en\u00ed bolesti v mozku a m\u00ed\u0161e. <\/p>\n\n\n\n

L\u00e9\u010dba pacient\u016f s chronickou bolest\u00ed obvykle zahrnuje postupn\u00e9 zvy\u0161ov\u00e1n\u00ed d\u00e1vek opioid\u016f, co\u017e \u010dasto vede k ne\u017e\u00e1douc\u00edm vedlej\u0161\u00edm \u00fa\u010dink\u016fm, jako je sedace, poruchy d\u00fdch\u00e1n\u00ed a z\u00e1cpa. <\/p>\n\n\n\n

Po ur\u010dit\u00e9 dob\u011b se u pacient\u016f za\u010dne projevovat tolerance a rezistence v\u016f\u010di d\u00e1vkov\u00e1n\u00ed opioid\u016f, nedosahuj\u00ed jejich terapeutick\u00fdch \u00fa\u010dink\u016f a nut\u00ed l\u00e9ka\u0159e opakovan\u011b zvy\u0161ovat d\u00e1vku, aby dos\u00e1hli stejn\u00e9 \u00farovn\u011b \u00falevy od bolesti.<\/p>\n\n\n\n

Vysok\u00e1 d\u00e1vka samotn\u00e9ho THC je pova\u017eov\u00e1na za analgetickou, ale obvykle je doprov\u00e1zena ne\u017e\u00e1douc\u00edmi vedlej\u0161\u00edmi \u00fa\u010dinky, jako je \u00fazkost, bolest hlavy, sucho v \u00fastech, z\u00e1vrat\u011b, euforie a tachykardie, zat\u00edmco n\u00edzk\u00e9 d\u00e1vky analgetick\u00fd \u00fa\u010dinek v\u016fbec nevyvol\u00e1vaj\u00ed. <\/p>\n\n\n\n

V kombinaci s opioidy se v\u0161ak tento \u00fa\u010dinek m\u016f\u017ee zcela zm\u011bnit.<\/p>\n\n\n\n

Studie proveden\u00e9 na zv\u00ed\u0159ec\u00edch modelech uk\u00e1zaly, \u017ee exogenn\u00ed kanabinoidy, jako je THC, mohou zv\u00fd\u0161it \u00fa\u010dinnost opioidn\u00edch l\u00e9k\u016f, jako je morfin. <\/p>\n\n\n\n

Zd\u00e1 se, \u017ee analgetick\u00e1 aktivita THC je zprost\u0159edkov\u00e1na opioidn\u00edmi receptory, p\u0159i\u010dem\u017e doch\u00e1z\u00ed ke zk\u0159\u00ed\u017een\u00e9 interakci mezi kanabinoidy a opioidy. <\/p>\n\n\n\n

V\u00fdzkumn\u00edci zab\u00fdvaj\u00edc\u00ed se konop\u00edm uv\u00e1d\u011bj\u00ed, \u017ee pod\u00e1v\u00e1n\u00ed THC m\u016f\u017ee v t\u011ble stimulovat produkci endogenn\u00edch opioidn\u00edch peptid\u016f, kter\u00e9 se nakonec v\u00e1\u017eou na ji\u017e zn\u00e1m\u00e9 opioidn\u00ed receptory - delta a kappa - a zprost\u0159edkov\u00e1vaj\u00ed tak \u00fa\u010dinek kanabinoid\u016f. <\/p>\n\n\n\n

P\u0159i pod\u00e1v\u00e1n\u00ed morfinu se aktivuje tak\u00e9 t\u0159et\u00ed opioidn\u00ed receptor mu. Aktivace t\u011bchto t\u0159\u00ed opioidn\u00edch receptor\u016f m\u016f\u017ee b\u00fdt vysv\u011btlen\u00edm zv\u00fd\u0161en\u00ed \u00fa\u010dinnosti antinociceptivn\u00edho \u00fa\u010dinku - procesu analgezie, kter\u00fd blokuje detekci bolestiv\u00e9ho podn\u011btu - ve srovn\u00e1n\u00ed s v\u00fdsledky l\u00e9\u010dby samotn\u00fdm morfinem nebo THC.<\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

A studie publikovan\u00e1 v roce 2004 v \u010dasopise Life Sciences<\/a> potvrdil spojen\u00ed mezi THC a morfinem inhibic\u00ed opioidn\u00edho receptoru pomoc\u00ed specifick\u00fdch molekul. <\/p>\n\n\n\n

P\u0159\u00edtomnost blokuj\u00edc\u00edch molekul vedla ke sn\u00ed\u017een\u00ed \u00fa\u010dinnosti morfinu a n\u00e1sledn\u011b i jeho terapeutick\u00fdch \u00fa\u010dink\u016f. <\/p>\n\n\n\n

Tento v\u00fdsledek potvrzuje, jak d\u016fle\u017eit\u00e1 je dostupnost t\u011bchto receptor\u016f a jejich aktivace pro \u00fa\u010dinnost l\u00e9\u010dby morfinem - a THC. Dal\u0161\u00ed experiment proveden\u00fd s naloxonem - antagonistou opioid\u016f - zablokoval aktivitu THC v r\u016fzn\u00fdch oblastech mozku, jako je ventr\u00e1ln\u00ed tegment\u00e1ln\u00ed oblast, hypotalamus a periakvedukt\u00e1ln\u00ed \u0161ed\u00e1 (PAG), co\u017e nazna\u010duje, \u017ee tyto oblasti jsou n\u011bjak\u00fdm zp\u016fsobem d\u016fle\u017eit\u00e9 pro interakci opioid-kanabinoid. <\/p>\n\n\n\n

Studie d\u00e1le uv\u00e1d\u00ed, \u017ee spole\u010dn\u00e1 l\u00e9\u010dba my\u0161\u00ed n\u00edzk\u00fdmi d\u00e1vkami THC a morfinu nevedla k toleranci na opioidy.<\/p>\n\n\n\n

Tato studie a mnoho dal\u0161\u00edch jsou publikov\u00e1ny na podporu my\u0161lenky, \u017ee kanabinoidy v kombinaci mohou zv\u00fd\u0161it \u00fa\u010dinek opioid\u016f. <\/p>\n\n\n\n

Kanabinoidy z\u0159ejm\u011b mohou tak\u00e9 zm\u011bnit toleranci a n\u00e1vykovost opioid\u016f. <\/p>\n\n\n\n

Dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed opioid\u016f je obvykle spojeno se z\u00e1vislost\u00ed pacient\u016f, kter\u00e1 vede ke zneu\u017e\u00edv\u00e1n\u00ed l\u00e1tky, je\u017e m\u011bla p\u016fvodn\u011b pouze l\u00e9\u010debn\u00fd \u00fa\u010del. <\/p>\n\n\n\n

Kombinace kanabinoid\u016f a opioid\u016f - nap\u0159\u00edklad THC a morfinu - by se proto mohla st\u00e1t novou analgetickou strategi\u00ed kombinovan\u00e9 l\u00e9\u010dby, kter\u00e1 l\u00e9ka\u0159\u016fm umo\u017en\u00ed sn\u00ed\u017eit vysok\u00e9 d\u00e1vky opioid\u016f u pacient\u016f a tak\u00e9 sn\u00ed\u017eit m\u00edru zneu\u017e\u00edv\u00e1n\u00ed opioid\u016f a z\u00e1vislosti pacient\u016f. <\/p>\n\n\n\n

Krom\u011b teorie kanabinoid\u016f stimuluj\u00edc\u00edch endogenn\u00ed opioidy z\u016fst\u00e1v\u00e1 podrobn\u00fd mechanismus interakce kanabinoid\u016f a opioid\u016f st\u00e1le nejasn\u00fd. <\/p>\n\n\n\n

Hypot\u00e9za, kter\u00e1 se sna\u017e\u00ed vysv\u011btlit mo\u017en\u00fd mechanismus \u00fa\u010dinku, je, \u017ee kanabinoidy mo\u017en\u00e1 indukuj\u00ed synt\u00e9zu nebo uvol\u0148ov\u00e1n\u00ed - oboj\u00ed - opioidn\u00edch peptid\u016f, \u010d\u00edm\u017e zvy\u0161uj\u00ed po\u010det aktivovan\u00fdch opioidn\u00edch receptor\u016f, co\u017e vede k analgetick\u00fdm hladin\u00e1m. <\/p>\n\n\n\n

Objasn\u011bn\u00ed toho, kter\u00e9 peptidy se na tomto procesu pod\u00edlej\u00ed, nen\u00ed jasn\u00e9 a ani zn\u00e1m\u00e9, tak\u017ee by pro v\u011bdce bylo z\u00e1sadn\u00ed pln\u011b pochopit strukturu t\u011bchto molekul a zp\u016fsob, jak\u00fdm lze kanabinoidy vyu\u017e\u00edt k dosa\u017een\u00ed analgetick\u00fdch \u00fa\u010dink\u016f, krom\u011b pomoci p\u0159i z\u00e1vislosti na opioidech. <\/p>\n\n\n\n

Kanabinoidy obecn\u011b v\u0161ak vykazuj\u00ed p\u0159ekvapiv\u00e9 v\u00fdsledky a neust\u00e1le z\u00edsk\u00e1vaj\u00ed prostor mezi l\u00e9ka\u0159i, co\u017e dokazuje jejich potenci\u00e1l jako alternativn\u00ed medic\u00edny. <\/p>\n\n\n\n

Je t\u0159eba prov\u00e9st je\u0161t\u011b n\u011bkolik studi\u00ed, aby v\u011bdci pln\u011b pochopili skute\u010dn\u00e9 p\u0159\u00ednosy a mo\u017enosti l\u00e9k\u016f na b\u00e1zi konop\u00ed pro lidsk\u00fd organismus a zjistili, jak je mo\u017en\u00e9 nejl\u00e9pe vyu\u017e\u00edt rostlinu konop\u00ed k l\u00e9\u010db\u011b.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

L\u00edbila se v\u00e1m infografika v tomto \u010dl\u00e1nku? V\u0161echny ikony<\/a> pou\u017eit\u00e9 v tomto \u010dl\u00e1nku - a mnoho dal\u0161\u00edch - jsou k dispozici v Mind the Graph. Dostupn\u00e9 ilustrace si m\u016f\u017eete prohl\u00e9dnout v na\u0161em galerie<\/a>.<\/p>\n\n\n\n

A nemus\u00edte za\u010d\u00ednat s infografikou od nuly, na\u0161im u\u017eivatel\u016fm nab\u00edz\u00edme upraviteln\u00e9 \u0161ablony infografik, tak\u017ee nemus\u00ed za\u010d\u00ednat od pr\u00e1zdn\u00e9ho pl\u00e1tna. Zde si m\u016f\u017eete prohl\u00e9dnout \u0161ablony infografik.<\/a><\/p>\n\n\n\n

M\u016f\u017eete m\u00edt tak\u00e9 p\u0159edplatn\u00e9 pro seniory a vytv\u00e1\u0159et neomezen\u00fd po\u010det figurek, klikn\u011bte zde a za\u010dn\u011bte<\/a>!<\/p>\n\n\n\n

Odkazy <\/strong><\/p>\n\n\n\n

BROWN, J. D.; WINTERSTEIN, A. G. Potenci\u00e1ln\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky a l\u00e9kov\u00e9 interakce p\u0159i u\u017e\u00edv\u00e1n\u00ed kanabidiolu (CBD) v l\u00e9ka\u0159stv\u00ed a pro spot\u0159ebitele. Journal of Clinical Medicine, v. 8, \u010d. 7, 8. \u010dervence 2019.<\/p>\n\n\n\n

CICHEWICZ, D. L. Synergick\u00e9 interakce mezi kanabinoidn\u00edmi a opioidn\u00edmi analgetiky. Life Sciences, v. 74, \u010d. 11, s. 1317-1324, 30. 1. 2004.<\/p>\n\n\n\n

HANEY, M.; BISAGA, A.; FOLTIN, R. W. Interakce mezi naltrexonem a peror\u00e1ln\u00edm THC u siln\u00fdch ku\u0159\u00e1k\u016f marihuany. Psychopharmacology, v. 166, \u010d. 1, s. 77-85, 1. \u00fanora 2003.<\/p>\n\n\n\n

KUHLEN, M. et al. \u00da\u010dinn\u00e1 l\u00e9\u010dba spasticity pomoc\u00ed dronabinolu v pediatrick\u00e9 paliativn\u00ed p\u00e9\u010di. European Journal of Paediatric Neurology, v. 20, \u010d. 6, s. 898-903, 1. 11. 2016.<\/p>\n\n\n\n

L\u00d6TSCH, J. et al. Drug Interactions with Patient-Controlled Analgesia (L\u00e9kov\u00e9 interakce s pacientem \u0159\u00edzenou analgezi\u00ed). Clinical Pharmacokinetics, v. 41, \u010d. 1, s. 31-57, 1. 1. 2002.<\/p>\n\n\n\n

LYNCH, M. E.; CLARK, A. J. Cannabis Reduces Opioid Dose in the Treatment of Chronic Non-Cancer Pain. Journal of Pain and Symptom Management, v. 25, \u010d. 6, s. 496-498, 1. \u010dervna 2003.<\/p>\n\n\n\n

MANZANARES, J. et al. Farmakologick\u00e9 a biochemick\u00e9 interakce mezi opioidy a kanabinoidy. Trends in Pharmacological Sciences, v. 20, \u010d. 7, s. 287-294, 1. \u010dervence 1999.<\/p>\n\n\n\n

WAKLEY, A. A.; CRAFT, R. M. Interakce THC-methadonu a THC-naltrexonu na diskriminaci, antinocicepci a lokomoci u potkan\u016f. Behavioural Pharmacology, v. 22, \u010d. 5 a 6, s. 489-497, soubor. 2011.<\/p>\n\n\n\n

WELCH, S. P. Interakce kanabinoidn\u00edho a opioidn\u00edho syst\u00e9mu v modulaci nocicepce. International Review of Psychiatry, v. 21, \u010d. 2, s. 143-151, 1. 1. 2009.<\/p>","protected":false},"excerpt":{"rendered":"

V uplynul\u00e9m desetilet\u00ed p\u0159ineslo mnoho klinick\u00fdch studi\u00ed pozitivn\u00ed a slibn\u00e9 v\u00fdsledky p\u0159i pou\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f na b\u00e1zi konop\u00ed k l\u00e9\u010db\u011b neuropatick\u00e9 bolesti. Konop\u00edm byla l\u00e9\u010dena bolest souvisej\u00edc\u00ed s cukrovkou, chemoterapi\u00ed, roztrou\u0161enou skler\u00f3zou, fibromyalgi\u00ed, osteoartritidou a n\u011bkolika dal\u0161\u00edmi. Z\u0159ejm\u011b existuje spojen\u00ed mezi exogenn\u00edmi kanabinoidy a opioidn\u00edmi receptory, co\u017e vede k ovlivn\u011bn\u00ed \u00fa\u010dinku opioid\u016f na [...]<\/p>","protected":false},"author":4,"featured_media":12276,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[66,959,958,28],"tags":[819,51,554],"yoast_head":"\nCannabis and Body Pain - MTG<\/title>\n<meta name=\"description\" content=\"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/cs\/konopi-a-bolest-tela\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cannabis and Body Pain - MTG\" \/>\n<meta property=\"og:description\" content=\"Do you want to know cannabis can impact the body pain? 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