{"id":12192,"date":"2021-01-27T10:46:16","date_gmt":"2021-01-27T12:46:16","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12192"},"modified":"2023-01-05T14:40:18","modified_gmt":"2023-01-05T17:40:18","slug":"cannabis-and-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/cs\/konopi-a-alzheimerova-choroba\/","title":{"rendered":"Co se v\u00ed o konop\u00ed a Alzheimerov\u011b chorob\u011b"},"content":{"rendered":"
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Alzheimerova choroba (AD) je neurodegenerativn\u00ed onemocn\u011bn\u00ed, kter\u00e9 je zodpov\u011bdn\u00e9 za v\u00edce ne\u017e 50% v sou\u010dasnosti diagnostikovan\u00fdch p\u0159\u00edpad\u016f demence a kter\u00e9 p\u0159\u00edmo souvis\u00ed se st\u00e1rnut\u00edm. V sou\u010dasn\u00e9 dob\u011b trp\u00ed ur\u010dit\u00fdm stupn\u011bm demence 40% osob star\u0161\u00edch 85 let.<\/p>\n\n\n\n

D\u0159\u00edve se m\u011blo za to, \u017ee p\u0159\u00edznaky Alzheimerovy choroby souvisej\u00ed pouze s poklesem kognitivn\u00edch funkc\u00ed, kter\u00e9 ovliv\u0148uj\u00ed kr\u00e1tkodob\u00e9 vzpom\u00ednky, zat\u00edmco v pokro\u010dil\u00fdch stadi\u00edch nemoci ovliv\u0148uj\u00ed jazykov\u00e9 schopnosti pacienta a dokonce i dlouhodob\u00e9 vzpom\u00ednky.<\/p>\n\n\n\n

Dnes je v\u0161ak zn\u00e1mo, \u017ee pacienti trp\u00edc\u00ed AD vykazuj\u00ed \u0159adu dal\u0161\u00edch p\u0159\u00edznak\u016f, jako jsou deprese, psych\u00f3zy, agresivn\u00ed chov\u00e1n\u00ed, kter\u00e9 onemocn\u011bn\u00ed je\u0161t\u011b zhor\u0161uj\u00ed. <\/p>\n\n\n\n

V posledn\u00edch letech v\u011bdci a l\u00e9ka\u0159i ve sv\u00fdch studi\u00edch uv\u00e1d\u011bj\u00ed pozitivn\u00ed v\u00fdsledky p\u0159i zah\u00e1jen\u00ed l\u00e9\u010dby pacient\u016f s Alzheimerovou chorobou l\u00e9ky na b\u00e1zi konop\u00ed, \u010d\u00edm\u017e dos\u00e1hli zm\u00edrn\u011bn\u00ed p\u0159\u00edznak\u016f.<\/p>\n\n\n\n

Endokanabinoidn\u00ed syst\u00e9m se stal alternativn\u00edm p\u0159\u00edstupem k l\u00e9\u010db\u011b r\u016fzn\u00fdch onemocn\u011bn\u00ed a patologi\u00ed, krom\u011b jeho vlivu na \u0159adu proces\u016f, jako je neuroplasticita, neuroz\u00e1n\u011bt, poruchy chov\u00e1n\u00ed, regulace sp\u00e1nku, imunologick\u00e9 funkce, z\u00e1n\u011btliv\u00e1 onemocn\u011bn\u00ed, kardiovaskul\u00e1rn\u00ed funkce, bolest, motorick\u00e1 kontrola, energetick\u00e1 rovnov\u00e1ha a chu\u0165 k j\u00eddlu. <\/p>\n\n\n\n

\"\"<\/a>
Fotografie od Ravi Patel<\/a> na adrese Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

Bohu\u017eel je st\u00e1le m\u00e1lo ofici\u00e1ln\u00edch studi\u00ed, kter\u00e9 by p\u0159\u00edmo analyzovaly vztah mezi endokanabinoidn\u00edm syst\u00e9mem a Alzheimerovou chorobou.<\/p>\n\n\n\n

Dnes je zn\u00e1mo, \u017ee p\u0159\u00ed\u010dinou Alzheimerovy choroby jsou genetick\u00e9 faktory a faktory souvisej\u00edc\u00ed se st\u00e1rnut\u00edm. Kl\u00ed\u010dov\u00ed vin\u00edci nemoci jsou p\u0159ipisov\u00e1ni tzv. seniln\u00ed plaky<\/strong> a neurofibril\u00e1rn\u00ed sple\u0165<\/strong>. <\/p>\n\n\n\n

Zaj\u00edmav\u00e9 je, \u017ee na modelech potkan\u016f s AD v\u011bdci zjistili, \u017ee mozky s AD maj\u00ed ni\u017e\u0161\u00ed po\u010det receptor\u016f CB1 ve srovn\u00e1n\u00ed se zdrav\u00fdmi mozky - men\u0161\u00ed po\u010det receptor\u016f CB1 m\u016f\u017ee v kone\u010dn\u00e9m d\u016fsledku sn\u00ed\u017eit terapeutick\u00fd \u00fa\u010dinek l\u00e9k\u016f.<\/p>\n\n\n\n

L\u00e9\u010dba kanabinoidy m\u016f\u017ee m\u00edt ochrann\u00fd \u00fa\u010dinek proti oxida\u010dn\u00edmu stresu a neuroz\u00e1n\u011btu v mozku pacient\u016f s Alzheimerovou chorobou a pom\u00e1h\u00e1 sni\u017eovat tvorbu amyloidn\u00edch plak\u016f a neurofibril\u00e1rn\u00edch splet\u00ed, \u010d\u00edm\u017e zpomaluje pokles kognitivn\u00edch funkc\u00ed pacient\u016f. <\/p>\n\n\n\n

A\u010dkoli se amyloidn\u00ed plaky nach\u00e1zej\u00ed i ve zdrav\u00fdch mozc\u00edch, jejich v\u00fdskyt je ve srovn\u00e1n\u00ed s mozkem s AD extr\u00e9mn\u011b n\u00edzk\u00fd.<\/p>\n\n\n\n

Studie zam\u011b\u0159en\u00e9 na pochopen\u00ed toho, pro\u010d maj\u00ed kanabinoidy terapeutick\u00fd \u00fa\u010dinek na pacienty s AD, zjistily, \u017ee molekula THC m\u00e1 schopnost zvy\u0161ovat biologickou dostupnost neurotransmiteru, kter\u00fd se naz\u00fdv\u00e1 \"neurotransmiter\". acetylcholin<\/strong> (Ach) inhibic\u00ed jeho degrada\u010dn\u00edho enzymu acetylcholinester\u00e1za<\/strong> (AChE) - Ach je v podstat\u011b zodpov\u011bdn\u00fd za p\u0159enos nervov\u00e9ho impulzu k dal\u0161\u00edmu neuronu. <\/p>\n\n\n\n

Enzym AChE m\u00e1 ve zdrav\u00e9m mozku za \u00fakol odbour\u00e1vat Ach, av\u0161ak v mozku s Alzheimerovou chorobou je tento enzym siln\u011b zastoupen a odbour\u00e1v\u00e1 mnohem v\u00edce Ach, ne\u017e by m\u011bl, co\u017e \u010dasem zp\u016fsobuje pokles pozn\u00e1vac\u00edch funkc\u00ed mozku.   <\/p>\n\n\n\n

V\u011bdci uv\u00e1d\u011bj\u00ed, \u017ee kanabinoidy mohou pom\u00e1hat d\u00edky sv\u00e9mu inhibi\u010dn\u00edmu \u00fa\u010dinku enzymu AChE - prok\u00e1zaly lep\u0161\u00ed reakce ne\u017e jin\u00e9 komer\u010dn\u011b dostupn\u00e9 l\u00e9ky. <\/p>\n\n\n\n

THC m\u016f\u017ee tak\u00e9 pomoci sn\u00ed\u017eit poruchy chov\u00e1n\u00ed a reguluje cirkadi\u00e1nn\u00ed cyklus pacient\u016f s t\u011b\u017ekou demenc\u00ed. N\u011bkte\u0159\u00ed v\u011bdci dokonce potvrzuj\u00ed, \u017ee kanabinoidy THC a CBD maj\u00ed potenci\u00e1l p\u016fsobit proti Alzheimerov\u011b chorob\u011b.<\/p>\n\n\n\n

\u010cl\u00e1nek publikovan\u00fd v roce 2015 v \u010dasopise Clinical Pharmacology and Therapeutics.<\/a>, poskytuje p\u0159ehled o potenci\u00e1lu kanabinoid\u016f v l\u00e9\u010db\u011b pozdn\u00ed Alzheimerovy choroby a souvisej\u00edc\u00edch neuropsychiatrick\u00fdch p\u0159\u00edznak\u016f u star\u0161\u00edch lid\u00ed a zab\u00fdv\u00e1 se tak\u00e9 aspekty l\u00e9\u010div\u00fdch p\u0159\u00edpravk\u016f na b\u00e1zi konop\u00ed z hlediska jejich \u00fa\u010dinnosti, bezpe\u010dnosti a farmakokinetiky.<\/p>\n\n\n\n

U 72let\u00e9ho mu\u017ee s Alzheimerovou chorobou se objevily poruchy chov\u00e1n\u00ed, jako je agitovanost a agresivita. Jeho p\u0159edchoz\u00ed l\u00e9\u010dba nevykazovala \u017e\u00e1dn\u00e9 v\u00fdznamn\u00e9 zlep\u0161en\u00ed. <\/p>\n\n\n\n

Kdy\u017e byl pacientovi nasazen Nabilon - syntetick\u00fd l\u00e9k THC -, brzy se u n\u011bj projevilo zlep\u0161en\u00ed poruchy chov\u00e1n\u00ed a dal\u0161\u00edch p\u0159\u00edznak\u016f, nav\u00edc b\u011bhem l\u00e9\u010dby l\u00e9kem na b\u00e1zi THC nem\u011bl \u017e\u00e1dn\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky.<\/p>\n\n\n\n

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Fotografie od Louis Reed<\/a> na adrese Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

Dal\u0161\u00ed studijn\u00ed skupina slo\u017een\u00e1 z patn\u00e1cti pacient\u016f s Alzheimerovou chorobou - pr\u016fm\u011brn\u00fd v\u011bk 72 let - vykazovala p\u0159ed l\u00e9\u010dbou poruchy chov\u00e1n\u00ed a probl\u00e9my s j\u00eddlem. <\/p>\n\n\n\n

Patn\u00e1ct pacient\u016f bylo po dobu \u0161esti t\u00fddn\u016f l\u00e9\u010deno dronabinolem - zn\u00e1m\u00fdm tak\u00e9 jako marinol - syntetick\u00fdm l\u00e9kem THC. <\/p>\n\n\n\n

Po ur\u010dit\u00e9 dob\u011b l\u00e9\u010dby se u nich projevilo zlep\u0161en\u00ed chov\u00e1n\u00ed, zv\u00fd\u0161en\u00ed hmotnosti a sn\u00ed\u017een\u00ed agitovanosti - ve srovn\u00e1n\u00ed s placebem. Byly zaznamen\u00e1ny n\u011bkter\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky, jako je \u00fanava, ospalost a euforie, u nich\u017e se potvrdilo, \u017ee jsou spojeny s dronabinolem.<\/p>\n\n\n\n

Dal\u0161\u00ed skupina \u0161esti pacient\u016f, pr\u016fm\u011brn\u00e9ho v\u011bku 81 let, z nich\u017e n\u011bkte\u0159\u00ed trp\u011bli Alzheimerovou chorobou a jin\u00ed t\u011b\u017ekou demenc\u00ed, zah\u00e1jila dvout\u00fddenn\u00ed l\u00e9\u010dbu dronabinolem. <\/p>\n\n\n\n

V\u00fdsledky uk\u00e1zaly v\u00fdrazn\u00e9 zlep\u0161en\u00ed no\u010dn\u00edch pohybov\u00fdch aktivit t\u011bchto pacient\u016f a lep\u0161\u00ed chov\u00e1n\u00ed. U t\u00e9to skupiny nebyly pozorov\u00e1ny \u017e\u00e1dn\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky.<\/p>\n\n\n\n

V jin\u00e9 studii byla zkoum\u00e1na skupina 40 pacient\u016f s r\u016fzn\u00fdmi stupni demence, z nich\u017e 13 trp\u011blo Alzheimerovou chorobou. <\/p>\n\n\n\n

V\u0161em byla zavedena l\u00e9\u010dba dronabinolem k l\u00e9\u010db\u011b probl\u00e9m\u016f s chov\u00e1n\u00edm a poruch chuti k j\u00eddlu. <\/p>\n\n\n\n

Doba l\u00e9\u010dby byla 17 dn\u00ed a pacienti se zlep\u0161ili v obou ohledech. Byly hl\u00e1\u0161eny ne\u017e\u00e1douc\u00ed \u00fa\u010dinky jako sedace, delirium, infekce mo\u010dov\u00fdch cest a zmatenost, ale podle v\u00fdzkumn\u00edk\u016f nebyly p\u0159\u00edmo spojeny s u\u017e\u00edv\u00e1n\u00edm dronabinolu.<\/p>\n\n\n\n

Navzdory n\u011bkolika studi\u00edm, jejich\u017e v\u00fdsledky ukazuj\u00ed pozitivn\u00ed v\u00fdsledky p\u0159i pou\u017eit\u00ed kanabinoid\u016f v l\u00e9\u010db\u011b pacient\u016f s demenc\u00ed, n\u011bkte\u0159\u00ed v\u011bdci tvrd\u00ed, \u017ee st\u00e1le neexistuje dostatek d\u016fkaz\u016f, kter\u00e9 by prok\u00e1zaly, \u017ee kanabinoidy jsou skute\u010dn\u011b dobr\u00e9 a bezpe\u010dn\u00e9 p\u0159i l\u00e9\u010db\u011b poruch chov\u00e1n\u00ed a demence.<\/p>\n\n\n\n

Ka\u017edop\u00e1dn\u011b v\u011bdci st\u00e1le \u010dast\u011bji uv\u00e1d\u011bj\u00ed, \u017ee se l\u00e9ky na b\u00e1zi konop\u00ed pou\u017e\u00edvaj\u00ed k l\u00e9\u010db\u011b pacient\u016f s Alzheimerovou chorobou, a nejen to, pou\u017e\u00edvaj\u00ed se tak\u00e9 p\u0159i l\u00e9\u010db\u011b Parkinsonovy choroby a autismu, p\u0159i\u010dem\u017e l\u00e9ka\u0159i a v\u011bdci uv\u00e1d\u011bj\u00ed, \u017ee se kvalita \u017eivota jejich pacient\u016f po zah\u00e1jen\u00ed u\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f na b\u00e1zi konop\u00ed zlep\u0161ila. To je v\u0161ak t\u00e9ma na dal\u0161\u00ed \u010dl\u00e1nek.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

Jste z oboru neurologie? V Mind the Graph je velk\u00e1 kategorie neurologick\u00fdch ilustrac\u00ed, kde najdete v\u0161e, co pot\u0159ebujete pro svou pr\u00e1ci nebo prezentaci z neurologie. Pod\u00edvejte se na zde<\/a>.  <\/strong><\/p>\n\n\n\n

Nebo <\/strong>hled\u00e1te biochemie <\/a>a molekul\u00e1rn\u00ed biologie<\/a> ilustrace najdete tak\u00e9 v Mind the Graph. <\/p>\n\n\n\n

A pokud budete pot\u0159ebovat cokoli dal\u0161\u00edho, jsme tu pro v\u00e1s. p\u0159ihl\u00e1\u0161en\u00ed k \u00fa\u010dtu<\/a> a po\u0161lete n\u00e1m zpr\u00e1vu do PO\u017d\u00c1DAT O IKONU<\/strong>. <\/p>\n\n\n\n

Odkazy<\/strong><\/p>\n\n\n\n

AHMED, A. I. A. et al. Cannabinoids in late-onset Alzheimer's disease. Klinick\u00e1 farmakologie a terapie<\/strong>, ro\u010d. 97, \u010d. 6, s. 597-606, 2015.<\/p>\n\n\n\n

AHMED, A. I. A. et al. Cannabinoids in late-onset Alzheimer's disease. Klinick\u00e1 farmakologie a terapie<\/strong>, ro\u010d. 97, \u010d. 6, s. 597-606, 2015.<\/p>\n\n\n\n

BALASH, Y. et al. L\u00e9\u010debn\u00e9 konop\u00ed u Parkinsonovy nemoci: Zku\u0161enosti pacient\u016f z re\u00e1ln\u00e9ho \u017eivota. Klinick\u00e1 neurofarmakologie<\/strong>, v. 40, \u010d. 6, s. 268-272, dez. 2017.<\/p>\n\n\n\n

BENITO, C. et al. Endokanabinoidn\u00ed syst\u00e9m a Alzheimerova choroba. Molekul\u00e1rn\u00ed neurobiologie<\/strong>, v. 36, \u010d. 1, s. 75-81, 1 p\u0159ed. 2007.<\/p>\n\n\n\n

DE FARIA, S. M. et al. \u00da\u010dinky akutn\u00edho pod\u00e1n\u00ed kanabidiolu na \u00fazkost a t\u0159es vyvolan\u00fd simulovan\u00fdm testem ve\u0159ejn\u00e9ho mluven\u00ed u pacient\u016f s Parkinsonovou chorobou. \u010casopis Journal of Psychopharmacology<\/strong>, ro\u010d. 34, \u010d. 2, s. 189-196, 1. \u00fanora 2020.<\/p>\n\n\n\n

FALCO, A. D. et al. DOEN\u00c7A DE ALZHEIMER: HIP\u00d3TESES ETIOL\u00d3GICAS E PERSPECTIVAS DE TRATAMENTO. Qu\u00edmica Nova<\/strong>, ro\u010d. 39, \u010d. 1, s. 63-80, leden 2016.<\/p>\n\n\n\n

LEEHEY, M. A. et al. Bezpe\u010dnost a sn\u00e1\u0161enlivost kanabidiolu u Parkinsonovy choroby: (1): Otev\u0159en\u00e1 studie s vylu\u010dov\u00e1n\u00edm d\u00e1vek (Open Label, Dose-Escalation Study). V\u00fdzkum konop\u00ed a kanabinoid\u016f<\/strong>, 19. b\u0159ezna. 2020.<\/p>\n\n\n\n

POLEG, S. et al. Cannabidiol jako navrhovan\u00fd kandid\u00e1t na l\u00e9\u010dbu poruch autistick\u00e9ho spektra. Pokroky v neuro-psychofarmakologii a biologick\u00e9 psychiatrii<\/strong>, v. 89, s. 90-96, 8. b\u0159ezna. 2019.YOO, K.-Y.; PARK, S.-Y. Terpenoidy jako potenci\u00e1ln\u00ed terapeutika proti Alzheimerov\u011b chorob\u011b. Molekuly<\/strong>, v. 17, \u010d. 3, s. 3524-3538, b\u0159ezen. 2012.<\/p>","protected":false},"excerpt":{"rendered":"

Alzheimerova choroba (AD) je neurodegenerativn\u00ed onemocn\u011bn\u00ed, kter\u00e9 je zodpov\u011bdn\u00e9 za v\u00edce ne\u017e 50% v sou\u010dasnosti diagnostikovan\u00fdch p\u0159\u00edpad\u016f demence a kter\u00e9 p\u0159\u00edmo souvis\u00ed se st\u00e1rnut\u00edm. V sou\u010dasn\u00e9 dob\u011b trp\u00ed ur\u010dit\u00fdm stupn\u011bm demence 40% osob star\u0161\u00edch 85 let. D\u0159\u00edve se m\u011blo za to, \u017ee p\u0159\u00edznaky AD souvisej\u00ed pouze s poklesem kognitivn\u00edch funkc\u00ed, kter\u00e9 ovliv\u0148uj\u00ed kr\u00e1tkodob\u00e9 vzpom\u00ednky, zat\u00edmco u [...]<\/p>","protected":false},"author":4,"featured_media":12193,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959],"tags":[213,819,554],"yoast_head":"\nWhat is Out There About Cannabis and Alzheimer\u2019s Disease - MTG<\/title>\n<meta name=\"description\" content=\"Do you know Cannabis and Alzheimer's Disease can be related? 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