{"id":12121,"date":"2021-01-11T11:05:53","date_gmt":"2021-01-11T13:05:53","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12121"},"modified":"2023-01-05T14:52:03","modified_gmt":"2023-01-05T17:52:03","slug":"cause-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/cs\/pricina-alzheimerovy-nemoci\/","title":{"rendered":"Nov\u00e1 teorie se sna\u017e\u00ed vysv\u011btlit p\u0159\u00ed\u010dinu Alzheimerovy choroby"},"content":{"rendered":"

V\u00edce ne\u017e polovina p\u0159\u00edpad\u016f demence je dnes klasifikov\u00e1na jako Alzheimerova choroba - chronick\u00e9 neurodegenerativn\u00ed onemocn\u011bn\u00ed, kter\u00e9 postupn\u011b ovliv\u0148uje pozn\u00e1vac\u00ed schopnosti a pam\u011b\u0165 \u010dlov\u011bka. <\/p>\n\n\n\n

A\u017e do dne\u0161n\u00ed doby se m\u011blo za to, \u017ee je zp\u016fsobena genetick\u00fdmi faktory a faktory st\u00e1rnut\u00ed, za zloduchy a hlavn\u00ed vin\u00edky nemoci jsou pova\u017eov\u00e1ny seniln\u00ed plaky a neurofibril\u00e1rn\u00ed spleti, kter\u00e9 vedou k neuroz\u00e1n\u011btu a n\u00e1sledn\u011b k odum\u00edr\u00e1n\u00ed neuron\u016f. <\/p>\n\n\n\n

Nov\u00e1 teorie p\u0159\u00ed\u010din Alzheimerovy choroby v\u0161ak vrh\u00e1 sv\u011btlo na nebe l\u00e9ka\u0159sk\u00e9ho v\u00fdzkumu. <\/p>\n\n\n\n

Podle t\u00e9to teorie nejsou genetika a st\u00e1rnut\u00ed jedin\u00fdmi faktory, kter\u00e9 jsou zodpov\u011bdn\u00e9 za tvorbu amyloidn\u00edch shluk\u016f - b\u00edlkoviny, kter\u00e1 se hromad\u00ed mezi neurony a zp\u016fsobuje Alzheimerovu chorobu - ale m\u016f\u017ee j\u00edt tak\u00e9 o spou\u0161t\u011bc\u00ed reakci na infekci mikroby.  <\/p>\n\n\n\n

Pod\u00edvejme se bl\u00ed\u017ee na neurologickou stupnici, abychom pochopili cel\u00fd obraz toho, co se d\u011bje v mozku s Alzheimerovou chorobou. Doch\u00e1z\u00ed ke dv\u011bma hlavn\u00edm jev\u016fm.<\/p>\n\n\n\n

Protein zvan\u00fd tau je zodpov\u011bdn\u00fd za udr\u017eov\u00e1n\u00ed stability t\u00edm, \u017ee poskytuje oporu mikrotubul\u016fm uvnit\u0159 neuron\u016f. V mozku trp\u00edc\u00edm t\u00edmto onemocn\u011bn\u00edm je tau biochemicky modifikov\u00e1n reakc\u00ed nazvanou hyperfosforyl\u00e1tov\u00e1 reakce. <\/p>\n\n\n\n

V\u00fdsledkem t\u00e9to zm\u011bny jsou nerozpustn\u00e9 kousky b\u00edlkovin uvnit\u0159 neuronu, kter\u00e9 rozkl\u00e1daj\u00ed cel\u00fd syst\u00e9m a zab\u00edjej\u00ed bu\u0148ky neuronu. <\/p>\n\n\n\n

Tyto nerozpustn\u00e9 kousky tau protein\u016f se vz\u00e1jemn\u011b agreguj\u00ed a vytv\u00e1\u0159ej\u00ed tzv. neurofibril\u00e1rn\u00ed spleti.<\/strong><\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Na str\u00e1nk\u00e1ch seniln\u00ed plaky<\/strong> jsou vyrobeny z peptidy amyloidu-\u03b2<\/strong>. Protein p\u0159\u00edtomn\u00fd v membr\u00e1n\u00e1ch neuron\u016f (pre-amyloid) proch\u00e1z\u00ed procesem \u0161t\u011bpen\u00ed, jeho\u017e v\u00fdsledkem jsou voln\u00e9 kousky amyloidu-\u03b2 mimo neurony*. <\/p>\n\n\n\n

Tyto kousky by \u00fadajn\u011b m\u011bly b\u00fdt z vn\u011bj\u0161\u00edho prost\u0159ed\u00ed neuronu vy\u010di\u0161t\u011bny speci\u00e1ln\u00edmi bu\u0148kami a enzymy prost\u0159ednictv\u00edm fagocyt\u00f3zy, ale kv\u016fli genetick\u00fdm faktor\u016fm nebo faktor\u016fm st\u00e1rnut\u00ed k tomuto procesu nedoch\u00e1z\u00ed dostate\u010dn\u011b \u00fa\u010dinn\u011b, co\u017e vede k tomu, \u017ee se voln\u00e9 kousky nerozpustn\u00fdch protein\u016f amyloidu-\u03b2 za\u010dnou shlukovat do plak\u016f.<\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Amyloidn\u00ed plaky jsou nej\u010dast\u011bji studovanou a diskutovanou p\u0159\u00ed\u010dinou Alzheimerovy choroby. V\u011bdci v\u0161ak tak\u00e9 potvrzuj\u00ed, \u017ee neurofibril\u00e1rn\u00ed spleti jsou p\u0159\u00edmo spojeny s progres\u00ed onemocn\u011bn\u00ed.<\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

V\u011bdci na\u0161li amyloidn\u00ed shluky tak\u00e9 ve zdrav\u00fdch mozc\u00edch. To znamen\u00e1, \u017ee ve zdrav\u00e9m star\u00e9m mozku se proces \u010di\u0161t\u011bn\u00ed tak\u00e9 st\u00e1v\u00e1 m\u00e9n\u011b efektivn\u00edm, ale ne tolik jako v mozku s Alzheimerovou chorobou.<\/p>\n\n\n\n

Proto je pro Alzheimerovu chorobu charakteristick\u00e9 velk\u00e9 mno\u017estv\u00ed t\u011bchto seniln\u00edch plak\u016f a neurofibril\u00e1rn\u00edch klubek, kter\u00e9 jsou pro mozek extr\u00e9mn\u011b toxick\u00e9 a m\u011bn\u00ed \u00fa\u010dinnost a kvalitu synaps\u00ed. <\/p>\n\n\n\n

U posti\u017een\u00fdch osob se projevuj\u00ed p\u0159\u00edznaky jako ztr\u00e1ta pam\u011bti, zmatenost v \u010dase a m\u00edst\u011b, deprese, \u00fazkost, jazykov\u00e9 a komunika\u010dn\u00ed probl\u00e9my, nestabilita n\u00e1lady a dal\u0161\u00ed.<\/p>\n\n\n\n

V nov\u011b navr\u017een\u00e9 teorii<\/strong>, jsou amyloidn\u00ed plaky mechanismem ochrany mozku p\u0159ed infekc\u00ed mikroby. <\/p>\n\n\n\n

Gen pro amyloid-\u03b2 je p\u0159\u00edtomen u velk\u00e9 \u010d\u00e1sti obratlovc\u016f a zachoval se nap\u0159\u00ed\u010d r\u016fzn\u00fdmi druhy po n\u011bkolik generac\u00ed, co\u017e znamen\u00e1, \u017ee by m\u011bl m\u00edt pro na\u0161e t\u011blo u\u017eite\u010dnou a d\u016fle\u017eitou roli a nem\u011bl by p\u016fsobit pouze jako n\u011bco \u0161kodliv\u00e9ho - kdyby nebyl n\u011b\u010d\u00edm u\u017eite\u010dn\u00fdm nebo prosp\u011b\u0161n\u00fdm, gen by evolu\u010dn\u00ed cestou d\u00e1vno zmizel.<\/p>\n\n\n\n

V\u011bdci vyhledali tis\u00edce posmrtn\u00fdch mozk\u016f lid\u00ed s Alzheimerovou chorobou. <\/p>\n\n\n\n

P\u0159esto\u017ee se p\u0159i anal\u00fdze t\u011bchto typ\u016f mozku pot\u00fdkali s obt\u00ed\u017eemi kv\u016fli \u0161patn\u00fdm podm\u00ednk\u00e1m, byli schopni studovat a shroma\u017e\u010fovat informace, aby pozd\u011bji navrhli n\u011bkolik mo\u017en\u00fdch spou\u0161t\u011b\u010d\u016f mikrob\u016f. <\/p>\n\n\n\n

Tyto spou\u0161t\u011b\u010de jsou obrann\u00fdmi mechanismy proti n\u011bkter\u00fdm typ\u016fm lidsk\u00fdch herpetick\u00fdch vir\u016f, jako jsou herpesvirus 1, 6A a 7, a t\u0159em bakteri\u00edm, Chlamydiov\u00e1 pneumonie<\/em>, Borrelia burgdorferi<\/em>, Porphyromonas gingivalis<\/em>.<\/p>\n\n\n\n

Teorie p\u0159edpokl\u00e1d\u00e1, \u017ee beta-amyloid m\u00e1 p\u016fvodn\u011b obrannou funkci, zachycuje mikroby, kter\u00e9 se pohybuj\u00ed sm\u011brem k mozku, a zastavuje tak mo\u017enou infekci nebo onemocn\u011bn\u00ed. <\/p>\n\n\n\n

Jak ji\u017e bylo zm\u00edn\u011bno, v d\u016fsledku faktor\u016f st\u00e1rnut\u00ed mozek ztr\u00e1c\u00ed schopnost \u00fa\u010dinn\u011b \u010distit amyloidy. P\u0159edstava o funkci amyloidu tak m\u016f\u017ee b\u00fdt po celou dobu myln\u00e1; pravd\u011bpodobn\u011b se pod\u00edl\u00ed na ur\u010dit\u00e9m druhu antimikrobi\u00e1ln\u00ed ochrany proti mozkov\u00fdm vet\u0159elc\u016fm, p\u0159i\u010dem\u017e je klasifikov\u00e1n jako antimikrobi\u00e1ln\u00ed peptid.<\/p>\n\n\n\n

V\u011bdci z\u00edskali pozitivn\u00ed v\u00fdsledky, kdy\u017e se sna\u017eili prok\u00e1zat, \u017ee \u03b2-amyloid m\u016f\u017ee zab\u00edjet mikroorganismy z n\u011bkolika b\u011b\u017en\u00fdch onemocn\u011bn\u00ed. <\/p>\n\n\n\n

Krom\u011b toho dal\u0161\u00ed studie, kter\u00e1 byla zah\u00e1jena v roce 2007 a m\u00e1 skon\u010dit v roce 2022 na Kolumbijsk\u00e9 univerzit\u011b v New Yorku, testuje antivirov\u00fd l\u00e9k u pacient\u016f s rakovinou. h<\/s>erpes simplex virus 1 a m\u00edrnou Alzheimerovu chorobu, aby se zjistilo, zda l\u00e9k m\u016f\u017ee zpomalit progresi onemocn\u011bn\u00ed. <\/p>\n\n\n\n

Zat\u00edm m\u016f\u017eeme jen doufat v nejlep\u0161\u00ed a \u010dekat na v\u00fdsledky.<\/p>\n\n\n\n

Tato nov\u011b navr\u017een\u00e1 teorie nen\u00ed st\u00e1le dob\u0159e p\u0159ij\u00edm\u00e1na celou v\u011bdeckou komunitou. Mnoz\u00ed v\u011bdci tvrd\u00ed, \u017ee i kdyby se tato nov\u00e1 teorie potvrdila, hlavn\u00ed p\u0159\u00ed\u010dinou onemocn\u011bn\u00ed budou st\u00e1le genetick\u00e9 faktory a \u0161patn\u00e9 mutace. <\/p>\n\n\n\n

Alzheimerova choroba je onemocn\u011bn\u00ed, o jeho\u017e skute\u010dn\u00fdch p\u0159\u00ed\u010din\u00e1ch m\u00e1 v\u011bda st\u00e1le jen velmi m\u00e1lo poznatk\u016f; neexistuje \u017e\u00e1dn\u00fd l\u00e9k a ani mnoho mo\u017enost\u00ed l\u00e9\u010dby. Pokud se tato teorie uk\u00e1\u017ee jako pravdiv\u00e1, mohl by to b\u00fdt prvn\u00ed krok sm\u011brem k lep\u0161\u00ed l\u00e9\u010db\u011b. Do toho v\u011bda!<\/p>\n\n\n\n

Odkazy<\/strong><\/p>\n\n\n\n

ABBOTT, A. Jsou n\u011bkter\u00e9 p\u0159\u00edpady Alzheimerovy choroby zp\u016fsobeny infekcemi? P\u0159\u00edroda<\/strong>, v. 587, \u010d. 7832, s. 22-25, 4. listopadu 2020.<\/p>\n\n\n\n

CEC\u00cd, K. et al. Biomarkery u Alzheimerovy choroby. Geriatrie, gerontologie a st\u00e1rnut\u00ed<\/strong>, v. 6, \u010d. 3, s. 273-282, 2012.<\/p>\n\n\n\n

MAKIN, S. Amyloidov\u00e1 hypot\u00e9za na zkou\u0161ku. P\u0159\u00edroda<\/strong>, v. 559, \u010d. 7715, s. S4-S7, 25. \u010dervence 2018.<\/p>\n\n\n\n

YOO, K.-Y.; PARK, S.-Y. Terpenoidy jako potenci\u00e1ln\u00ed l\u00e9\u010diva proti Alzheimerov\u011b chorob\u011b. Molekuly<\/strong>, v. 17, \u010d. 3, s. 3524-3538, b\u0159ezen. 2012.<\/p>\n\n\n\n

___
Pokud pot\u0159ebujete vytvo\u0159it infografiku pro v\u011bdeck\u00e9 \u00fa\u010dely - jako j\u00e1 - m\u016f\u017eete v Mind the Graph vytvo\u0159it jak\u00fdkoli druh infografiky, kterou pot\u0159ebujete a chcete. Tato platforma je tu proto, aby se z v\u011bdc\u016f stali design\u00e9\u0159i, kte\u0159\u00ed zv\u00fd\u0161\u00ed sv\u016fj dopad! P\u0159ipojte se k n\u00e1m na platform\u011b, klikn\u011bte zde<\/a>!<\/p>","protected":false},"excerpt":{"rendered":"

V\u00edce ne\u017e polovina p\u0159\u00edpad\u016f demence je dnes klasifikov\u00e1na jako Alzheimerova choroba - chronick\u00e9 neurodegenerativn\u00ed onemocn\u011bn\u00ed, kter\u00e9 postupn\u011b ovliv\u0148uje pozn\u00e1vac\u00ed schopnosti a pam\u011b\u0165 \u010dlov\u011bka. A\u017e do dne\u0161n\u00edch dn\u016f se m\u011blo za to, \u017ee je zp\u016fsobena genetick\u00fdmi faktory a faktory st\u00e1rnut\u00ed, zlosynov\u00e9 a hlavn\u00ed vin\u00edci nemoci jsou p\u0159ipisov\u00e1ni [...]<\/p>","protected":false},"author":4,"featured_media":12125,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[213,554,964,136],"yoast_head":"\nNew Theory Tries to Explain The Cause of Alzheimer\u2019s<\/title>\n<meta name=\"description\" content=\"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. Know what scientists and researchers have found.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/cs\/cauza-bolii-alzheimer\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Theory Tries to Explain The Cause of Alzheimer\u2019s\" \/>\n<meta property=\"og:description\" content=\"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. 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He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. 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