{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/cs\/coronavirus-covid-19-is-hydroxychloroquin-new-hope-apparently-yes\/","title":{"rendered":"Koronavirus (Covid-19): je hydroxychlorochin novou nad\u011bj\u00ed? Z\u0159ejm\u011b ano."},"content":{"rendered":"<p>Dv\u011b ned\u00e1vn\u00e9 pr\u00e1ce shrnuj\u00edc\u00ed jeden v\u00fdzkum in vitro a malou klinickou studii sta\u010dily Donaldu Trumpovi k tomu, aby FDA prosadil novou klinickou indikaci pro hydroxychlorochin: zlep\u0161en\u00ed p\u0159\u00edznak\u016f pacient\u016f posti\u017een\u00fdch koronavirem (Covid-19).<\/p>\n<p>Jedn\u00e1 se pravd\u011bpodobn\u011b o nejrychlej\u0161\u00ed pr\u016fb\u011bh schvalovac\u00edho procesu l\u00e9k\u016f v novodob\u00e9 historii a prezident m\u00e1 z\u0159ejm\u011b pravdu. P\u0159ekvapiv\u00e9 u glob\u00e1ln\u00edho v\u016fdce, kter\u00fd nem\u00e1 v\u011bdu p\u0159\u00edli\u0161 v l\u00e1sce.<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-10976\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2020\/03\/image-192.png\" alt=\"\" width=\"607\" height=\"480\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2020\/03\/image-192.png 607w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2020\/03\/image-192-300x237.png 300w\" sizes=\"(max-width: 607px) 100vw, 607px\" \/><\/p>\n<p>Prvn\u00ed d\u016fkazy o p\u016fsoben\u00ed hydroxychlorochinu na virus poch\u00e1zej\u00ed z publikace <a href=\"https:\/\/www.nature.com\/articles\/s41421-020-0156-0\">tento \u010dl\u00e1nek byl v\u010dera zve\u0159ejn\u011bn na str\u00e1nk\u00e1ch Cell Discovery<\/a>Je to jen in vitro se v\u0161emi omezen\u00edmi, ale jasn\u011b to ukazuje potenci\u00e1l l\u00e9ku zab\u00edjet virus. V dob\u011b p\u0159edlo\u017een\u00ed pr\u00e1ce bylo v \u010c\u00edn\u011b potvrzeno 80 000 p\u0159\u00edpad\u016f, v\u010detn\u011b 2946 \u00famrt\u00ed, a tak\u00e9 v\u00edce ne\u017e 10 566 potvrzen\u00fdch p\u0159\u00edpad\u016f v 72 dal\u0161\u00edch zem\u00edch. V t\u00e9 dob\u011b se nejv\u011bt\u0161\u00ed nad\u011bje vkl\u00e1daly do l\u00e9ku zvan\u00e9ho remdesivir.<\/p>\n<figure id=\"attachment_10973\" aria-describedby=\"caption-attachment-10973\" style=\"width: 584px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-10973\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2020\/03\/image-191.png\" alt=\"in vitro \u00fa\u010dinky hydrochlorochinu na koronavirus (Covid-19)\" width=\"584\" height=\"401\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2020\/03\/image-191.png 584w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2020\/03\/image-191-300x206.png 300w\" sizes=\"(max-width: 584px) 100vw, 584px\" \/><figcaption id=\"caption-attachment-10973\" class=\"wp-caption-text\">In vitro \u00fa\u010dinky hydrochlorochinu na koronavirus (Covid-19). Sloupec vpravo ukazuje \u00fa\u010dinky \u00fa\u010dinn\u00e9ho l\u00e9\u010diva na rozd\u00edl od chlorochinu nebo kontroln\u00ed skupiny vlevo. Ukazuje, \u017ee l\u00e9k zlep\u0161il schopnost bun\u011bk vytla\u010dovat viry... je to jako pomoci vyhnat necht\u011bn\u00e9ho souseda z va\u0161eho domu. Pom\u00e1h\u00e1 to! \ud83d\ude42&nbsp;<\/figcaption><\/figure>\n<p>Nejv\u011bt\u0161\u00ed novinku v\u0161ak p\u0159inesla mal\u00e1 klinick\u00e1 studie zve\u0159ejn\u011bn\u00e1 den p\u0159edt\u00edm. Jej\u00ed n\u00e1zev zn\u00ed <a href=\"https:\/\/www.mediterranee-infection.com\/wp-content\/uploads\/2020\/03\/Hydroxychloroquine_final_DOI_IJAA.pdf\">Hydroxychlorochin a azitromycin jako l\u00e9\u010dba COVID-19: v\u00fdsledky otev\u0159en\u00e9 nerandomizovan\u00e9 klinick\u00e9 studie a lze je st\u00e1hnout v jej\u00ed \"in press\" verzi.<\/a><\/p>\n<p>Ve studii s pouh\u00fdmi 20 pacienty auto\u0159i prok\u00e1zali, \u017ee hydroxychlorochin je \u00fa\u010dinn\u00fd proti infekci koronavirem Covid-19. Ve skute\u010dnosti sn\u00ed\u017eil 75% infikovan\u00fdch jedinc\u016f b\u011bhem 6 dn\u016f, co\u017e je \u00fa\u017easn\u00e9. Je\u0161t\u011b lep\u0161\u00ed bylo, \u017ee kombinace s azitromycinem zlep\u0161ila \u00fa\u010dinnost l\u00e9\u010dby na 95%.<\/p>\n<figure id=\"attachment_10975\" aria-describedby=\"caption-attachment-10975\" style=\"width: 668px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-10975\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2020\/03\/Hydroxychloroquine_final_DOI_IJAA-24-1024x546-1.jpg\" alt=\"Kombinovan\u00e1 l\u00e9\u010dba hydrohychlorochinem a azitromycinem je \u00fa\u010dinn\u00e1 proti koronavirov\u00fdm infekc\u00edm (Covid-19) u lidsk\u00fdch pacient\u016f\" width=\"668\" height=\"356\"><figcaption id=\"caption-attachment-10975\" class=\"wp-caption-text\">Kombinovan\u00e1 l\u00e9\u010dba hydrohychlorochinem a azitromycinem je \u00fa\u010dinn\u00e1 proti koronavirov\u00fdm infekc\u00edm (Covid-19) u lidsk\u00fdch pacient\u016f. Pokles je dramatick\u00fd a p\u0159in\u00e1\u0161\u00ed posti\u017een\u00fdm pacient\u016fm novou nad\u011bji.<\/figcaption><\/figure>\n<p>L\u00e9\u010dba zlep\u0161ila p\u0159\u00edznaky a z\u00e1rove\u0148 sn\u00ed\u017eila virovou z\u00e1t\u011b\u017e u pacient\u016f. L\u00e9k byl ji\u017e d\u0159\u00edve schv\u00e1len pro l\u00e9\u010dbu mal\u00e1rie, co\u017e znamen\u00e1, \u017ee je pova\u017eov\u00e1n za bezpe\u010dn\u00fd. \"Sestersk\u00fd\" l\u00e9k chlorochin byl m\u00e9n\u011b \u00fa\u010dinn\u00fd. To je pro n\u00e1s dob\u0159e, proto\u017ee je algo toxi\u010dt\u011bj\u0161\u00ed.<\/p>\n<p>Studie nebyla randomizovan\u00e1 a byla provedena v mal\u00e9m m\u011b\u0159\u00edtku, nicm\u00e9n\u011b se zd\u00e1, \u017ee epidemie sice za\u010dala v \u010c\u00edn\u011b, ale \u0159e\u0161en\u00ed je v\u00fdsledkem \u00fasil\u00ed celosv\u011btov\u00e9 komunity. Pr\u00e1ce in vitro je skute\u010dn\u011b \u010d\u00ednsk\u00e1, zat\u00edmco klinick\u00e1 je evropsk\u00e1, p\u0159esn\u011bji z Francie. Zaj\u00edmav\u00e9 je, \u017ee p\u016fvodn\u00ed registrace l\u00e9ku hydroxychlorochin je od francouzsk\u00e9 farmaceutick\u00e9 spole\u010dnosti Sanofi a ned\u00e1vn\u00e1 klinick\u00e1 studie byla provedena v Marseille. Ale le bleu!<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.medscape.com\/viewarticle\/927033#vp_1\">Pro z\u00e1jemce o podrobn\u011bj\u0161\u00ed informace je na Medscape k dispozici vynikaj\u00edc\u00ed \u010dl\u00e1nek.<\/a><\/p>\n<p>Citujte pros\u00edm tuto pr\u00e1ci jako Gautret et al. (2020) Hydroxychlorochin a azitromycin jako l\u00e9\u010dba COVID-19: v\u00fdsledky otev\u0159en\u00e9 nerandomizovan\u00e9 klinick\u00e9 studie. International Journal of Antimicrobial Agents - V tisku 17. b\u0159ezna 2020 - DOI : 10.1016\/j.ijantimicag.2020.105949.<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Coronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. 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He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. 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