{"id":16636,"date":"2022-09-10T18:27:00","date_gmt":"2022-09-10T21:27:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16636"},"modified":"2023-03-17T14:47:45","modified_gmt":"2023-03-17T17:47:45","slug":"success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/bg\/%d1%83%d1%81%d0%bf%d0%b5%d1%88%d0%b5%d0%bd-%d1%81%d0%bb%d1%83%d1%87%d0%b0%d0%b9-fgf-%d1%81%d0%b8%d0%b3%d0%bd%d0%b0%d0%bb%d0%b8%d0%b7%d0%b8%d1%80%d0%b0%d0%bd%d0%b5-%d0%b2-%d1%81%d0%b0%d0%bc%d0%be%d0%be\/","title":{"rendered":"FGF \u0441\u0438\u0433\u043d\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u044f \u043f\u0440\u0438 \u0441\u0430\u043c\u043e\u043e\u0431\u043d\u043e\u0432\u044f\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u043e\u0440\u0433\u0430\u043d\u043e\u0438\u0434\u0438 \u043d\u0430 \u0440\u0430\u043a \u043d\u0430 \u0434\u0435\u0431\u0435\u043b\u043e\u0442\u043e \u0447\u0435\u0440\u0432\u043e \u041f\u0440\u0435\u0433\u043b\u0435\u0434 \u043d\u0430 \u0434\u043e\u043a\u0443\u043c\u0435\u043d\u0442\u0438"},"content":{"rendered":"

\u0418\u043d\u0432\u0430\u043b\u0438\u0434\u0438\u0437\u0438\u0440\u0430\u043d\u043e\u0442\u043e \u043e\u0431\u0440\u0430\u0437\u0443\u0432\u0430\u043d\u0435 \u043d\u0430 \u0441\u0444\u0435\u0440\u043e\u0438\u0434\u0438 \u0438 \u043e\u0440\u0433\u0430\u043d\u043e\u0438\u0434\u0438 \u0447\u0440\u0435\u0437 \u0438\u043d\u0445\u0438\u0431\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 FGFR \u0432 \u043a\u043b\u0435\u0442\u043a\u0438 \u043d\u0430 CRC, \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u0438 \u043e\u0442 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438, \u0435 \u043c\u043d\u043e\u0433\u043e \u043f\u043e-\u043b\u0435\u0441\u043d\u043e \u0437\u0430 \u0440\u0430\u0437\u0431\u0438\u0440\u0430\u043d\u0435 \u0441 \u043f\u043e\u043c\u043e\u0449\u0442\u0430 \u043d\u0430 \u0438\u043b\u044e\u0441\u0442\u0440\u0430\u0446\u0438\u0438\u0442\u0435 \u043d\u0430 Mind the Graph. <\/p>\n\n\n\n

\u0421\u0445\u0435\u043c\u0430\u0442\u0430, \u0441\u044a\u0437\u0434\u0430\u0434\u0435\u043d\u0430 \u043e\u0442 \u0430\u0432\u0442\u043e\u0440\u0430, \u043f\u043e\u043a\u0430\u0437\u0432\u0430, \u0447\u0435 \u0445\u0438\u0440\u0443\u0440\u0433\u0438\u0447\u043d\u0438\u0442\u0435 \u0431\u0438\u043e\u043f\u0441\u0438\u0438 \u0441\u0435 \u0440\u0430\u0437\u0433\u0440\u0430\u0436\u0434\u0430\u0442 \u0435\u043d\u0437\u0438\u043c\u043d\u043e, \u0437\u0430 \u0434\u0430 \u0441\u0435 \u043f\u043e\u043b\u0443\u0447\u0438 \u0441\u0443\u0441\u043f\u0435\u043d\u0437\u0438\u044f \u043e\u0442 \u0435\u0434\u0438\u043d\u0438\u0447\u043d\u0438 \u043a\u043b\u0435\u0442\u043a\u0438. \u041d\u0430\u0438\u0432\u043d\u0438\u0442\u0435 \u043d\u0435\u0441\u043e\u0440\u0442\u0438\u0440\u0430\u043d\u0438 \u043a\u043b\u0435\u0442\u043a\u0438 \u0441\u0435 \u043a\u0443\u043b\u0442\u0438\u0432\u0438\u0440\u0430\u0442 \u0432 \u0441\u0440\u0435\u0434\u0430, \u0441\u044a\u0434\u044a\u0440\u0436\u0430\u0449\u0430 FGF2, \u0438\u043b\u0438 \u0441 FGFR-\u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440 SU-5402.<\/p>\n\n\n\n

\u0420\u043e\u043b\u044f\u0442\u0430 \u043d\u0430 \u0444\u0438\u0431\u0440\u043e\u0431\u043b\u0430\u0441\u0442\u043d\u0438\u044f \u0440\u0430\u0441\u0442\u0435\u0436\u0435\u043d \u0444\u0430\u043a\u0442\u043e\u0440 2 (FGF2) \u0432 \u0441\u0430\u043c\u043e\u043e\u0431\u043d\u043e\u0432\u044f\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u0438\u0442\u0435 \u043a\u043b\u0435\u0442\u043a\u0438 \u043d\u0430 \u043a\u043e\u043b\u043e\u0440\u0435\u043a\u0442\u0430\u043b\u043d\u0438\u044f \u0440\u0430\u043a \u0435 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0430<\/strong><\/h2>\n\n\n\n

\u0412 \"FGF Signalling in the Self-Renewal of Colon Cancer Organoids\" (FGF \u0441\u0438\u0433\u043d\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u044f \u043f\u0440\u0438 \u0441\u0430\u043c\u043e\u043e\u0431\u043d\u043e\u0432\u044f\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u043e\u0440\u0433\u0430\u043d\u043e\u0438\u0434\u0438 \u043e\u0442 \u0440\u0430\u043a \u043d\u0430 \u0434\u0435\u0431\u0435\u043b\u043e\u0442\u043e \u0447\u0435\u0440\u0432\u043e) J\u00f6rg Otte \u0438 \u043a\u043e\u043b\u0435\u0433\u0438\u0442\u0435 \u043c\u0443 (2019 \u0433.) \u0441\u044a\u043e\u0431\u0449\u0430\u0432\u0430\u0442, \u0447\u0435 \u043a\u043e\u0433\u0430\u0442\u043e \u043d\u0430\u0438\u0432\u043d\u0438 \u0435\u0434\u0438\u043d\u0438\u0447\u043d\u0438 \u043a\u043b\u0435\u0442\u043a\u0438 \u0441\u0430 \u0432\u0433\u0440\u0430\u0434\u0435\u043d\u0438 \u0432 Matrigel \u0438 \u043a\u0443\u043b\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0438 \u0432 \u0441\u0440\u0435\u0434\u0430 \u043d\u0430 CSC, \u043f\u0440\u0438 \u0432\u0441\u0438\u0447\u043a\u0438 \u0430\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u0430\u043d\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438 \u0441\u0435 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u0432\u0430 \u043f\u043e-\u0441\u043b\u043e\u0436\u043d\u0430 \u0441\u0430\u043c\u043e\u043e\u0440\u0433\u0430\u043d\u0438\u0437\u0430\u0446\u0438\u044f. <\/p>\n\n\n\n

\u0423\u0441\u0442\u0430\u043d\u043e\u0432\u0435\u043d\u043e \u0435, \u0447\u0435 \u0433\u0435\u043d\u0438\u0442\u0435, \u043f\u0440\u044f\u043a\u043e \u0441\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u0441 \u0415\u041c\u0422, \u043a\u0430\u043a\u0442\u043e \u0438 \u0441 \u043c\u0435\u0437\u0435\u043d\u0445\u0438\u043c\u043d\u0438\u044f \u0438 \u0441\u0430\u043c\u043e\u043e\u0431\u043d\u043e\u0432\u044f\u0432\u0430\u0449\u0438\u044f \u0441\u0435 \u0444\u0435\u043d\u043e\u0442\u0438\u043f (TGFB3, ID1, ID2 \u0438 ID4), \u0441\u0430 \u0441\u0432\u0440\u044a\u0445\u0435\u043a\u0441\u043f\u0440\u0435\u0441\u0438\u0440\u0430\u043d\u0438 \u0432 \u043e\u0440\u0433\u0430\u043d\u043e\u0438\u0434\u0438\u0442\u0435. <\/p>\n\n\n\n

\u0414\u043e\u043a\u0430\u0442\u043e \u0438\u043d\u0445\u0438\u0431\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 FGFR \u0432\u043e\u0434\u0438 \u0434\u043e \u0437\u0430\u0441\u0438\u043b\u0435\u043d\u0430 MAPK \u0441\u0438\u0433\u043d\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u044f, \u0442\u0435 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u0432\u0430\u0442 \u0438\u043d\u0434\u0443\u0446\u0438\u0440\u0430\u043d\u0430 \u0434\u0438\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0430\u0446\u0438\u044f, \u0437\u0430\u0433\u0443\u0431\u0430 \u043d\u0430 \u043f\u043e\u0432\u0435\u0447\u0435\u0442\u043e \u043c\u0430\u0440\u043a\u0435\u0440\u0438 \u043d\u0430 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u0438\u0442\u0435 \u043a\u043b\u0435\u0442\u043a\u0438 \u0438 \u0435\u043f\u0438\u0442\u0435\u043b\u0435\u043d \u0444\u0435\u043d\u043e\u0442\u0438\u043f. <\/p>\n\n\n\n

\u0420\u0430\u043a\u043e\u0432\u0438\u0442\u0435 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u0438 \u043a\u043b\u0435\u0442\u043a\u0438 \u0441\u0430 \u0441\u0443\u0431\u043f\u043e\u043f\u0443\u043b\u0430\u0446\u0438\u044f \u043e\u0442 \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u0438 \u043a\u043b\u0435\u0442\u043a\u0438, \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u0438 \u0434\u0430 \u0441\u0435 \u0441\u0430\u043c\u043e\u043e\u0431\u043d\u043e\u0432\u044f\u0432\u0430\u0442 \u0438 \u0434\u0430 \u0441\u043b\u0443\u0436\u0430\u0442 \u043a\u0430\u0442\u043e \u043f\u043e\u0441\u0442\u043e\u044f\u043d\u0435\u043d \u0438\u0437\u0442\u043e\u0447\u043d\u0438\u043a \u043d\u0430 \u0434\u0438\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0440\u0430\u043d\u0438 \u0442\u0443\u043c\u043e\u0440\u043d\u0438 \u043a\u043b\u0435\u0442\u043a\u0438. \u0412 \u043d\u044f\u043a\u043e\u0438 \u043f\u0440\u043e\u0442\u043e\u043a\u043e\u043b\u0438 \u0437\u0430 \u043a\u0443\u043b\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 CSC \u0444\u0438\u0431\u0440\u043e\u0431\u043b\u0430\u0441\u0442\u043d\u0438\u044f\u0442 \u0440\u0430\u0441\u0442\u0435\u0436\u0435\u043d \u0444\u0430\u043a\u0442\u043e\u0440 2 \u0435 \u0432\u0430\u0436\u043d\u0430 \u0441\u044a\u0441\u0442\u0430\u0432\u043a\u0430 \u0437\u0430 \u043f\u043e\u0434\u0434\u044a\u0440\u0436\u0430\u043d\u0435 \u043d\u0430 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u0438\u044f \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440. <\/p>\n\n\n\n

\u041e\u0442 \u0434\u0440\u0443\u0433\u0430 \u0441\u0442\u0440\u0430\u043d\u0430, \u0432 \u043a\u0443\u043b\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0438\u0442\u0435 \u043e\u0440\u0433\u0430\u043d\u043e\u0438\u0434\u0438 \u0441 CSC \u0441\u0440\u0435\u0434\u0430 \u0442\u0435 \u043e\u0442\u043a\u0440\u0438\u0432\u0430\u0442 \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u044f \u043d\u0430 TGF-\u03b2 \u0438 \u043d\u0430 \u0432\u0441\u0438\u0447\u043a\u0438\u0442\u0435 \u0447\u0435\u0442\u0438\u0440\u0438 \u0447\u043b\u0435\u043d\u0430 \u043d\u0430 \u0441\u0435\u043c\u0435\u0439\u0441\u0442\u0432\u043e\u0442\u043e \u043d\u0430 \u0433\u0435\u043d\u0438\u0442\u0435 \u0437\u0430 \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440 \u043d\u0430 \u0434\u0438\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0430\u0446\u0438\u044f\u0442\u0430.<\/p>\n\n\n\n

\u0412 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435\u0442\u043e \u0441\u0430 \u0432\u043a\u043b\u044e\u0447\u0435\u043d\u0438 9 \u043f\u043e\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u043d\u0438 \u043d\u0435\u0441\u0435\u043b\u0435\u043a\u0442\u0438\u0440\u0430\u043d\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438 \u0441 \u0420\u041c\u0416.<\/strong><\/p>\n\n\n\n

\u041f\u0440\u043e\u0432\u0435\u0440\u0435\u0442\u0435 \u043e\u0440\u0438\u0433\u0438\u043d\u0430\u043b\u043d\u0430 \u0441\u0442\u0430\u0442\u0438\u044f \u0442\u0443\u043a<\/a>.<\/p>\n\n\n\n

\u0413\u0440\u0430\u0444\u0438\u0447\u043d\u043e \u0440\u0435\u0437\u044e\u043c\u0435, \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430\u043d\u043e \u043e\u0442 Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
\n
\"\"<\/a>
\u0418\u0437\u0440\u0430\u0431\u043e\u0442\u0435\u043d \u0441 Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\u041d\u044f\u043a\u043e\u0438 \u043e\u0442 \u0437\u0430\u043a\u043b\u044e\u0447\u0435\u043d\u0438\u044f\u0442\u0430 \u0438\u043c \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b\u043d\u043e \u0443\u043a\u0440\u0435\u043f\u0432\u0430\u0442 \u0434\u043e\u0441\u0435\u0433\u0430\u0448\u043d\u0438\u0442\u0435 \u043f\u043e\u0437\u043d\u0430\u043d\u0438\u044f \u0432 \u0442\u0430\u0437\u0438 \u043e\u0431\u043b\u0430\u0441\u0442: \"\u0421\u0432\u044a\u0440\u0437\u0430\u043d\u0438\u0442\u0435 \u0441 \u043f\u043b\u0443\u0440\u0438\u043f\u043e\u0442\u0435\u043d\u0442\u043d\u043e\u0441\u0442\u0442\u0430 \u0433\u0435\u043d\u0438 NANOG, LIN28 \u0438 SALL1 \u0441\u0435 \u0435\u043a\u0441\u043f\u0440\u0435\u0441\u0438\u0440\u0430\u0442 \u0438\u0437\u043a\u043b\u044e\u0447\u0438\u0442\u0435\u043b\u043d\u043e \u043e\u0442 hESCs. GO-\u0442\u0435\u0440\u043c\u0438\u043d\u0438\u0442\u0435 \"\u043d\u0435\u0433\u0430\u0442\u0438\u0432\u043d\u0430 \u0440\u0435\u0433\u0443\u043b\u0430\u0446\u0438\u044f \u043d\u0430 \u0441\u0438\u0433\u043d\u0430\u043b\u043d\u0438\u044f \u043f\u044a\u0442 \u043d\u0430 BMP\" \u0438 \"\u0441\u0438\u0433\u043d\u0430\u043b\u043d\u0430 \u0442\u0440\u0430\u043d\u0441\u0434\u0443\u043a\u0446\u0438\u044f \u043d\u0430 SMAD \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0438\" \u0431\u044f\u0445\u0430 \u043e\u0442\u043a\u0440\u0438\u0442\u0438 \u0432 \u043d\u0430\u0448\u0430\u0442\u0430 hESC \u043a\u0443\u043b\u0442\u0443\u0440\u0430\", \u043f\u0440\u0435\u0434\u043f\u043e\u043b\u0430\u0433\u0430 Otte.<\/p>\n\n\n\n

\u0410\u0432\u0442\u043e\u0440\u0438\u0442\u0435 \u043f\u0440\u0438\u0437\u043d\u0430\u0432\u0430\u0442, \u0447\u0435 \"\u0430\u043d\u0430\u043b\u0438\u0437\u044a\u0442 \u043d\u0430 GO-term \u043d\u0430 \u0442\u043e\u0437\u0438 \u043d\u0430\u0431\u043e\u0440 \u043e\u0442 \u0433\u0435\u043d\u0438 \u0435 \u0434\u0430\u043b \u0441\u0430\u043c\u043e \u043d\u044f\u043a\u043e\u043b\u043a\u043e \u0437\u043d\u0430\u0447\u0438\u043c\u0438 \u0440\u0435\u0437\u0443\u043b\u0442\u0430\u0442\u0430 \u043f\u043e\u0440\u0430\u0434\u0438 \u043c\u0430\u043b\u043a\u0438\u044f \u0431\u0440\u043e\u0439 \u0447\u0435\u0441\u0442\u043e \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430\u043d\u0438 \u0433\u0435\u043d\u0438. \u041f\u043e\u0432\u0435\u0447\u0435\u0442\u043e \u043e\u0442 \u0442\u0435\u0437\u0438 GO-\u0442\u0435\u0440\u043c\u0438\u043d\u0438 \u0437\u0430 \u0441\u044a\u0441\u0442\u043e\u044f\u043d\u0438\u0435\u0442\u043e \u043d\u0430 CSC-\u0441\u0440\u0435\u0434\u043d\u0430 \u0441\u0442\u0435\u043f\u0435\u043d \u0441\u0430 \u0441\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u0441 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u0442\u0440\u0430\u043d\u0441\u043a\u0440\u0438\u043f\u0446\u0438\u044f, \u043a\u043b\u0435\u0442\u044a\u0447\u043d\u0430 \u043f\u0440\u043e\u043b\u0438\u0444\u0435\u0440\u0430\u0446\u0438\u044f \u0438\u043b\u0438 \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u043e \u0443\u0441\u0432\u043e\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u0430. <\/p>\n\n\n\n

\u0421\u043b\u0435\u0434 \u0438\u043d\u0445\u0438\u0431\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 FGFR \u043e\u0442\u043a\u0440\u0438\u0445\u043c\u0435 \u0440\u0435\u0433\u0443\u043b\u0430\u0442\u043e\u0440\u0438 \u043d\u0430 \u043a\u043b\u0435\u0442\u044a\u0447\u043d\u0438\u044f \u0446\u0438\u043a\u044a\u043b, \u043a\u0430\u043a\u0442\u043e \u0438 \u043c\u043d\u043e\u0433\u043e \u0433\u0435\u043d\u0438, \u0430\u043d\u043e\u0442\u0438\u0440\u0430\u043d\u0438 \u043a\u0430\u0442\u043e \"\u0434\u0438\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0430\u0446\u0438\u044f \u043d\u0430 \u0435\u043f\u0438\u0442\u0435\u043b\u043d\u0438\u0442\u0435 \u043a\u043b\u0435\u0442\u043a\u0438\", \"\u0445\u0440\u0430\u043d\u043e\u0441\u043c\u0438\u043b\u0430\u043d\u0435\" \u0438\u043b\u0438 \"\u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442 \u043d\u0430 \u0436\u043b\u044a\u0447\u043d\u0438 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0438 \u0438 \u0436\u043b\u044a\u0447\u043d\u0438 \u0441\u043e\u043b\u0438\".\"<\/p>\n\n\n\n

\u0414\u043e\u043a\u0443\u043c\u0435\u043d\u0442\u0438 \u0412\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0438 \u0435\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442<\/strong><\/h2>\n\n\n\n

\u041c\u043e\u0436\u0435\u043c \u0434\u0430 \u0430\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u0430\u043c\u0435 \u0441 Altmetric<\/a> \u0434\u0430\u043d\u043d\u0438, \u0447\u0435 \u043e\u0446\u0435\u043d\u043a\u0430\u0442\u0430 \u043d\u0430 \u043e\u043d\u043b\u0430\u0439\u043d \u0432\u043d\u0438\u043c\u0430\u043d\u0438\u0435\u0442\u043e \u043d\u0430 \u0442\u043e\u0437\u0438 \u0434\u043e\u043a\u0443\u043c\u0435\u043d\u0442 \u0435 \u043f\u043e-\u0432\u0438\u0441\u043e\u043a\u0430 \u043e\u0442 68%<\/strong><\/strong> \u043e\u0442 \u0432\u0441\u0438\u0447\u043a\u0438 \u0434\u0440\u0443\u0433\u0438 \u0441\u0442\u0430\u0442\u0438\u0438 \u043d\u0430 \u043f\u043e\u0434\u043e\u0431\u043d\u0430 \u0432\u044a\u0437\u0440\u0430\u0441\u0442 \u0432 Scientific Reports.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/a>
\u0418\u0437\u0442\u043e\u0447\u043d\u0438\u043a: Altmetrics<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\u041f\u043e\u0434\u043e\u0431\u0440\u0435\u0442\u0435 \u0434\u043e\u0441\u0442\u044a\u043f\u043d\u043e\u0441\u0442\u0442\u0430 \u043d\u0430 \u0441\u0442\u0430\u0442\u0438\u044f\u0442\u0430 \u0441\u0438 \u0438 \u0441 \u043f\u043e\u043c\u043e\u0449\u0442\u0430 \u043d\u0430 \u0438\u043d\u0444\u043e\u0433\u0440\u0430\u0444\u0438\u043a\u0438\u0442\u0435.<\/p>\n\n\n\n

\n
\u041e\u043f\u0438\u0442\u0430\u0439\u0442\u0435 Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

\u041e\u0431\u0440\u0430\u0437\u0443\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0443\u0432\u0440\u0435\u0434\u0435\u043d\u0438 \u0441\u0444\u0435\u0440\u043e\u0438\u0434\u0438 \u0438 \u043e\u0440\u0433\u0430\u043d\u043e\u0438\u0434\u0438 \u0447\u0440\u0435\u0437 \u0438\u043d\u0445\u0438\u0431\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 FGFR \u0432 CRC \u043a\u043b\u0435\u0442\u043a\u0438, \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u0438 \u043e\u0442 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438, \u0435 \u043f\u043e-\u043b\u0435\u0441\u043d\u043e \u0437\u0430 \u0440\u0430\u0437\u0431\u0438\u0440\u0430\u043d\u0435 \u0441 \u043d\u0430\u0448\u0438\u0442\u0435 \u0438\u043b\u044e\u0441\u0442\u0440\u0430\u0446\u0438\u0438.<\/p>","protected":false},"author":29,"featured_media":20014,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,1],"tags":[96,554,775,963],"yoast_head":"\nFGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/bg\/\u0443\u0441\u043f\u0435\u0448\u0435\u043d-\u0441\u043b\u0443\u0447\u0430\u0439-fgf-\u0441\u0438\u0433\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u0430\u043d\u0435-\u0432-\u0441\u0430\u043c\u043e\u043e\/\" \/>\n<meta property=\"og:locale\" content=\"bg_BG\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/bg\/\u0443\u0441\u043f\u0435\u0448\u0435\u043d-\u0441\u043b\u0443\u0447\u0430\u0439-fgf-\u0441\u0438\u0433\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u0430\u043d\u0435-\u0432-\u0441\u0430\u043c\u043e\u043e\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-10T21:27:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_4.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_4.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - 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